Jaya Mary Thomas, PhD Student
Arteriovenous malformations (AVM) are tangles of dysplastic blood vessels which shunt blood from arteries to veins with no intervening capillary bed. AVM can occur in different organs such as liver, lungs, brain etc. Cerebral AVMs, are important causal factors of intracranial hemorrhage which may result in permanent disability or death, if not corrected surgically. The molecular milieu of this disease is complicated and pathogenesis of these malformations remains an enigma. In this context I like to focus on combination of genetic and epigenetic alterations of angiogenic specification and molecules conferring vascular stability in the pathogenesis of AVM.