Dr. Ajith Kumar G S, MVSc, CSIR-SRF
Antioxidative and antiapoptotic effect of endothelial mediators in cardiac hypertrophy and heart failure
Endocardial endothelial (EEC) cells and the micro vascular endothelial cells (MVEC) are the two different types of endothelial cells influencing heart’s function. Both are involved in modulation of myocardial performance by autocrine and paracrine mediators. Endocardial endothelial cells regulate underlying myocardial cells and are structurally and functionally dissimilar from vascular endothelial cells. Endocardial endothelial cells are continuously exposed to the flowing blood in the heart and thus serve as a sensor of signals such as shear stress, vasoactive substances, inflammatory molecules and oxidizing and antioxidizing agents.Endocardial endothelial cell dysfunction is seen similarly as micro vascular endothelial cell dysfunction in pathological conditions of heart. The structural and functional status of the EECs appreciably influences the outcome in various pathological conditions. I propose to analyze the functional significance of candidate mediator molecules of EEC origin in myocardial performance under oxidative stress conditions as well as in cardiac hypertrophy and heart failure.