The main object of the invention is to synthesis the novel class of gel-like dendrimer polymeric resins with high chemical, mechanical stability. So to rectifying all the existing defects and drawbacks of PS-DVB resin and other hydrophobic resins, the present work aim to introduce flexible PEG chains as dendrimer sites to hydrophobic resins through novel attachment patterns. The attachment of multiple dendritic PEG units to the hydrophobic system makes it completely solvent like gel. The main advantage of the proposed resins is due to its high functional loading and biocompatibility compared with known, national and international PEG-based resins.

Nanoparticle can improve the bioavailabity of poorly absorbed drugs and nanoparticles are able to penetrate cells for cellular internalization and connective tissue penetration and so deliver the drug efficiently to the targeted tissue. The treatment of diseases not only requires the development and testing of new drugs, but also the minimization of their adverse effects without impairing the quality of life of the patient. Controlled drug delivery is a promising method in this field. It occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug in such a way that the drug is released in a predesigned manner. It helps in achieving more effective therapies by eliminating the potential for both under and overdosing. Other advantages include the maintenance of drug levels within desired range, the need for fewer administrations, and increased patient compliance. In this area I am trying to develop novel biodegrading polymer nanoparticles and polymer film based implant for controlled drug delivery applications in cancer.

The application of biodegradable polymeric particles in the scale of nanometers as a controlled release dosage form of anticancer drugs has generated immense interest among researchers. Nanoparticle can improve the bioavailabity of poorly absorbed drugs and nanoparticles are able to penetrate cells for cellular internalization, it can penetrate connective tissue hence the drug delivery can be efficiently done to the targeted tissue without clogging capillaries. In the present area I am concentrating to develop new biodegradable polymeric nanoparticles as new drug releasing system in cancer for cell penetration and site specific delivery of drugs. In addition to this I aim to design new growth factor releasing system with a novel technique.

Many attempts have been made to engineer, small caliber arterial substitutes involving synthetic polymeric materials coupled with biological modification to improve biocompatibility. Occurrence of thrombosis is still a main problem encountered in small diameter blood vessel reconstruction with polymeric materials. Many polymer based scaffolds employed, failed to achieve the necessary compliance like cell adhesion, proliferation and growth factor release. Development of matrices with all properties is still a challenge. Effort to enhance the functional property of these systems, I am looking in the present work a possible novel vascular graft of multilayer cell seeding on a new polymer. The study aims at preparing three dimensional spongy hybrid carrier scaffolds for multi purpose vascular application: requiring Vascular Smooth Muscle Cell [VSMC] and [EC] adhesion, proliferation and growth factor signaling.

The main goal of the proposed work is to develop a polymeric delivery system for paclitaxel and curcumin, capable of increasing the therapeutic index of the drug, devoid of adverse effects. Biodegradable Polyethyleneglycol (PEG) coated naoparticles have been found to posses important potential therapeutic applications as injectable colloidal systems for the controlled release of drugs and site-specific drug delivery. Here we are incorporating two properties to increase the long term circulation of polymer nanoparticles to reach the tumor tissue, with specific recognition capacity.