DISC Facility – Publications

Publications
  • Novel Multiple Mutations in the Topoisomerase Gene of Haitian Variant Vibrio cholerae O1.,Divya MP, Sivakumar KC, Sarada Devi K, Remadevi S, Thomas S., Antimicrob Agents Chemother. 2014 Aug;58(8):4982-3.
  • Developmental wave of Brn3b expression leading to RGC fate specification is synergistically maintained by miR-23a and miR-374.,Rasheed VA1, Sreekanth S, Dhanesh SB, Divya MS, Divya TS, Akhila PK, Subashini C, Chandrika Sivakumar K, Das AV, James J.,Devel Neurobio, 2014 Jun; 74: 1155-1171.
  • Nisha E Thomas, Reshma Thamkachy, KC Sivakumar, KJ Sreedevi, Xavier Lieben, Sannu A Thomas, Rohith Kumar, Kallikat N Rajasekharan, Lynne Cassimeris, Suparna Sengupta., Reversible Action of Diaminothiazoles in Cancer Cells is Implicated by the Induction of a Fast Conformational Change of Tubulin and Suppression of Microtubule Dynamics., Mol Cancer Ther. 2014 Jan;13(1):179-89.
  • Nimmy Augustine, A.K. Goel, KC Sivakumar, R. Ajay Kumar, Sabu Thomas., Resveratrol - A potential inhibitor of biofilm formation in Vibrio cholera., Phytomedicine. 2013 Oct 29. pii: S0944-7113(13)00367-X.
  • Mithun V Varghese, Annapoorna K, Sivakumar KC, Sathish Mundayoor, GS Vinodkumar., Dry powder cationic lipopolymeric nanomicelle inhalation for targeted delivery of antitubercular drug to alveolar macrophage., Int J Nanomedicine. 2013; 8: 2871-2885.
  • Thasni KA, Ratheeshkumar T, Rojini G, Sivakumar KC, Rakesh Sathish N, Srinivas G, Asoke B, Veena S, Priya S., Structure activity relationship of plumbagin in BRCA1 related cancer cells., Mol Carcinog. 2013 May;52(5):392-403.
  • Mani T, Sivakumar KC, Manjula S. Expression and Functional Analysis of Two Osmotin(PR5) Isoforms with Differential Antifungal Activity from Piper colubrinum: Prediction of Structure-Function Relationship by Bioinformatics Approach. Mol Biotechnol., 2012 Nov;52(3):251-61.
  • Sivakumar KC, Dhanesh SB, Shobana S, James J, Mundayoor S. A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways., OMICS. 2011 Oct; 15(10):729-37.
  • V. Mallika, Sivakumar KC, and E.V. Soniya.PKSIIIexplorer: TSVM approach for predicting Type III polyketide synthase proteins., Bioinformation, 2011; 6(3):125-7.
  • V. Mallika, Sivakumar KC, and E.V. Soniya.Evolutionary Implications and Physicochemical Analyses of Selected Proteins of Type III Polyketide Synthase Family., Evol Bioinform, 2011; 7: 41-53.
  • Mallika V, Sivakumar K C, S Jaichand and E V Soniya., Kernel based machine learning algorithm for the efficient prediction of type III polyketide synthase family of proteins. Journal of Integrative Bioinformatics, 2010; 7(1):143.
  • Mallika V, Sivakumar KC, Soniya EV., A novel system for predicting plant protein kinase superfamily by using machine learning methodology. ACM Digital Library, 2010.
  • Soja Saghar Soman, K.C. Sivakumar, E.Sreekumar., Molecular dynamics simulation studies and in vitro site directed mutagenesis of avian beta-defensin Apl_AvBD2. BMC Bioinformatics 2010; 11(Suppl 1):S7.
  • Aswati Nair R, Kiran AG, Sivakumar KC, and George Thomas., Molecular characterization of an oomycete-responsive PR-5 protein gene from Zingiber zerumbet. Plant Mol Biol Rep, 2010; 28:128-135.
  • Radhakrishnan EK, Sivakumar KC, Soniya EV Molecular Characterization of Novel form of Type III Polyketide Synthase from Zingiber Officinale Rosc. and its Analysis using Bioinformatics Method. J Proteomics Bioinform, 2009; 2: 310-315.
  • Majumder Syamantak, Rajaram Megha, Muley Ajit, Seerapu Himabindu Reddy, Tamilarasan KP, Kolluru Gopi Krishna, Sinha Swaraj, Siamwala Jamila, Gupta Ravi, Ilavarasan R, Venkataraman S, Sivakumar KC, Anishetty Sharmila, Kumar Pradeep G, Chatterjee Suvro., Thalidomide attenuates nitric oxide driven angiogenesis by interplaying with soluble guanylate cyclase., British Journal of Pharmacology, 2009, 158(7): 1720 - 1734.
  • Sivakumar, K.C., Thomas, B. and Karunagaran, D. 'Three dimensional structure of the closed conformation (active) of human merlin reveals masking of actin binding site in the FERM domai', International Journal of Bioinformatics Research and Applications 2009; 5(5): 516 - 524.
Paper/Poster Presentations :
  • Radhakrishnan, E.K., Sivakumar, K.C., and Soniya, E.V. "A bioinformatics approach for deciphering the structural details of Chalcone Synthase gene family in the ginger to study its role in functional and evolutionary metabolomics" was presented in conjunction with International Conference on Bioinformatics. 18-20 December 2006, New Delhi.
  • Radhakrishnan, E.K., Sivakumar, K.C., and Soniya, E.V. "Genetic Profiling of Phenyl-Propanoid Pathway in Ginger" was presented in conjunction with International Conference on Biotechnology and Plant Genomics, October 26, 2007, Raipur.
  • Thasni, K.A., Sivakumar, K.C., and Priya Srinivas. A paper entitled "Mechanism of action of plumbagin in brca1 blocked ovarian cancer cells: an analysis by suppression subtractive hybridization (ssh) and micro array" Proceedings of the 19th Kerala Science Congress 29-31, Januvary 2007.Kannur.
  • Anilkumar A.K., Sivakumar K.C., Madhavi Latha G.K., Ajaykumar and Sathish Mundayoor. "Prevalence of KatG Ser315Thr substitution and Conformation Dynamics of Isoniazid binding among Isoniazid resistant Mycobacterium tuberculosis isolates from Kerala, India", International Conference on New Horizons in Biotechnology, November 26-29, 2007, Trivandrum.
  • Mallu Ravi., Jasna J. Mohan., Sivakumar K.C., Pradeep Kumar G., and Malini Laloraya. "New Dimensions in function of Fibulin, a seceratory protein at embryo implantation". The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology(AOSCE), December 10-14, 2007 North Bengal University, West Bengal.
  • Rakesh S. Nair., Sivakumar K.C., Eswaranpooti Manoj., Ratheesh kumar, T.M.R. Prathapachandra Kurup, Srinivas G and Priya Srinivas. "Induced fit DNA recognition in a cisplatin binding groove by carbohydrazone: structural fluctuations investigated through molecular dynamics simulations". Proceedings of International Symbosium on Computational Biology, Bioinformatics and Synthetic biolgy, Januvary 2008, Centre for Bioinformatics, University of Kerala, Trivandrum.
  • Radhakrishnan, E.K., Sivakumar, K.C., and Soniya, E.V. "A new approach to possible substrate binding mechanisms for Type III Polyketide Synthases", Proceedings of International Symbosium on Computational Biology, Bioinformatics and Synthetic biolgy, Januvary 2008, Centre for Bioinformatics, University of Kerala, Trivandrum. (Received Best Poster Award).
  • Anilkumar A.K., Sivakumar K.C., Madhavi latha G.K., Ajaykumar. R and Sathish Mundayoor. "Conformation dynamics of Isoniazid and Rifampicin bound to wild and mutant KATG, INHA and RPOB from multidrug resistant Mycobacterium tuberculosis", Proceedings of International Symbosium on Computational Biology, Bioinformatics and Synthetic biolgy, Januvary 2008, Centre for Bioinformatics, University of Kerala, Trivandrum. (Received Best Second Poster Award).
  • Madhavi Latha G.K., Sivakumar K.C., Anilkumar A.K., Ajaykumar. R and Sathish Mundayoor. "Molecular simulation and interaction studies of HAD like Phosphatease(Rv3813c)-A conserved hypothetical protein from Mycobacterium tuberculosis", Proceedings of International Symbosium on Computational Biology, Bioinformatics and Synthetic biolgy, Januvary 2008, Centre for Bioinformatics, University of Kerala, Trivandrum.
  • P. J. Vivek, K. C. Sivakumar and E. V. Soniya, "Homology Modeling and Interaction Studies of Calcium Dependant Protein Kinase from Zingiber officinale Rosc." presented at International Symposium on Industrial Biotechnology (BIOVISION 2008) on November 15 - 17, 2008(Received Best Paper Award).
  • Mallika V, Sivakumar KC, Soniya EV: Evolutionary analysis of type III polyketide synthases and development of an integrated database was presented at the International Symposium Bioinoformatica Indica 2010 held from 11-13 of January 2010 at Centre for Bioinformatics, University of Kerala.
  • Anisha V, Sivakumar K.C, Sathish Mundayoor: Targeting the response regulator LuxO in Vibrio cholerae quorum sensing mechanism: A promising approach to regulate virulence and biofilm formation was presented at the International Symposium Bioinoformatica Indica 2010 held from 11-13 of January 2010 at Centre for Bioinformatics, University of Kerala.
  • Vivek PJ, Sivakumar KC, Resmi MS, Soniya EV: Molecular docking of importin with ginger CDPK: insight into possible stress responsive nuclear localization was presented at the The Eighth Asia-Pacific Bioinformatics Conference, APBC2010, held from 18-21 of January 2010 at IISc. Bangalore, India.
  • Mallika V, Sivakumar KC, Soniya EV: PKSIIIpred: an insilico tool for efficient prediction of type III polyketide synthase family of proteins was presented at the The Eighth Asia-Pacific Bioinformatics Conference, APBC2010, held from 18-21 of January 2010 at IISc. Bangalore, India.
  • Mallika V, Sivakumar KC, Soniya EV: A novel system for predicting plant protein kinase superfamily by using machine learning methodology was presented at the International Symposium on Biocomputing held from 15-17 of February 2010, at NIT, Calicut, Kerala.

How to contact

Phone (O) : +91-0471-2342315 ext: 425

Fax : +91-0471-2348096

Email : disc@rgcb.res.in, sivakumar@rgcb.res.in

Coordinator : Dr. Sathish Mundayoor

Technical Officer : Mr. K. C. Sivakumar