RGCB – DISC Facility

The Distributed Information Sub-Centre (Bioinformatics Centre) at RGCB, setup and funded by DBT, GOI under the National Bioinformatics Network program started functioning from May 2002 with a view to catering the needs of the scientific community and to augmenting their research activities through information inputs. The main function of the Centre is to act as a member of Bioinformatics Network System for providing information to the interested users on topics pertaining to the relevant areas of Biotechnology specially genomics and proteomics.

Objectives
  • To provide a national bio-information network designed to bridge the inter disciplinary gaps in biotechnology information and to establish link among scientists in organizations involved in R&D and manufacturing activities in biotechnology
  • To build up information resources, prepare databases on biotechnology and to develop relevant information handling tools and techniques
  • To evolve and implement program on education of users and training of information scientists responsible for handling of biotechnology information and its applications to biotechnology research and development.
  • To develop, support and enhance public information resources for biotechnology e.g. Gene banks, molecular biology data and related research information resources.
Main Thrust Area
  • Database and Software development in biotechnology
  • Sequence Analysis and Molecular Modeling
Infrastructure

To keep pace with the development in the bioinformatics field, impetus is given to set up the necessary computational infrastructure and resources for the research community. The Centre has access to online CDAC Tera-scale Super computing Facility (CTSF) on Param Padma Super Computer situated at CDAC-Bangalore. The center has upgraded its computational resources by setting up high performance computing facility. Twelve Intel Core-i7 Desktop PC's (customized for parallel computing), Three Dell PowerEdge T300 Workstations and Five Dell Vostro 400 PC. The molecular modeling package Accelrys Discovery Studio 2.0 purchased on DBT grant is used for a molecular modeling, docking and simulation studies. Apart from commercial package Discovery Studio2.0, the centre have popular Open bioinformatics softwares such as, EMBOSS, Autodock, WHATIF, MODELLER ClustalW, Phylip, Cn3D, Rasmol, HMMR, MEGA4, XMGRACE, GROMACS, FTDOCK, PyMol, Jackal, Patchdock, Z-dock etc.

National Seminars and Workshops

Organizing periodic training programmes and seminars has been an integral part of the centre. The centre has been successful in creating awareness among scientists, researchers, students and those interested in the field of bioinformatics. For the last several years, Centre was contributing significantly for the manpower development by organizing workshops and seminars in the field of bioinformatics funded by DBT. Details of various seminars and workshops conducted by DISC are given below :

  • National Seminar on Bioinformatics (NSB'03), 23rd July 2003.
  • National Seminar on Bioinformatics (NSB'04), 14th - 16th December 2004.
  • National Conference and Workshop on Molecular Modeling (NCWMM'06), 21st - 24th March 2006.
  • "Workshop on Molecular Modeling using InsightII - Molecular Visualization and Homology Modeling", 15th - 19th November 2007.
  • "Workshop on Computer Aided Drug Design", 1st - 2nd August 2008.
Training

Information dissemination and training is one of the mandates of the facility. Many students from outside universities and institutes avail this opportunity. Short term trainees from different parts of the country have undertaken their M Sc/B.tech dissertation at DISC, were provided guidance and to utilizes this facility. Most of the students do their project in the areas of molecular modeling, structure based drug designing, software and database development. Under the Traineeship and Studentship programme of DISC, selected postgraduates undergo extensive training in bioinformatics tools and techniques, availing a fellowship of Rs. 5000/month for a period of six months. They are given hands on training in Molecular dynamics, Molecular modeling, Docking, Cluster computing, Database creation, Protein Structure Studies, Genomics and Systems Biology.