Profile

Research

Publications

Team

Alumni

Rashmi Mishra, PhD

Scientist EI

+91-471-2529593

rashmimishra@rgcb.res.in

RASHMI-1
  • Profile

    • PhD degree in Neuroscience from the National Brain Research Centre, Manesar, India
    • Masters' in Medical Biotechnology from the All India Institute of Medical Sciences, New Delhi
    • 2016 - till date Scientist EI, Rajiv Gandhi Centre for Biotechnology, Trivandrum, India
    • 2012-2016, DBT-Ramalingaswami Fellow and Scientist C at Rajiv Gandhi Centre for Biotechnology, Trivendrum, India
    • 2008-2011, Postdoctoral fellow at Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany and Curie Institut, Paris, France
    • 2003-2004, Visiting Fellow, Tufts University School of Medicine, Boston, USA
    • 2012 : Selected for DBT-Rapid Grant for Young Investigator Award (RGYI)
    • 2012-2017: Department of Biotechnology, Ramalingaswami fellowship award
    • 2008-2010: Max Planck Institute post-doctoral fellowship
    • 2008: Center for Developmental Biology, RIKEN, Japan, travel fellowship for ‘Turning Neurons to Brain’ conference.
    • 2001: Council for Scientific Research, Govt. of India, Junior and Senior Research fellowship (CSIR-NET) for pursuing PhD degree.
    • 2003-2004: Visiting Fellow (funded by FIRCA-NIH, USA), Tufts University School of Medicine, Boston, USA
    • 2003: First Rank in Pre-PhD Neuroscience Course work
    • 2001: Indian Institute of Technology, India (IIT, Graduate Aptitude Test in Engineering) 82 percentile
    • 1998-2000: Dept of Biotechnology, Govt. of India fellowship for pursuing Masters’ in Medical Biotechnology
    • 1997: Delhi University Merit Medal for first position in Bachelors degree with Honors.
  • Research

    Brain sciences and brain associated diseases are now being pursued with more cross-disciplinary approaches at the interface of understanding the plasma membrane resident modules, their communication with the micro and macroenvironments and the net consequences of such interactions on cellular functioning. In this context, the two principles that we have recognized to be crucial to brain pathophysiology are the clustering induced biomechanical force alterations of surface membranes and the assembly/disassembly kinetics of lipid rafts modules.

    Hence, the central theme of our current research is to elucidate the design principles that may remodel the surface dynamics of brain tumor, neural stem cells and neurons which may crucially influence the progression of disease phenotypes

    1. Rapid Grant for Young Investigator,Department of Biotechnology, 2013-2016
    2. Ramalingaswami Fellowship,Department of Biotechnology, 2012-2017
    3. Neuro TaskForce Grant,Department of Biotechnology, 2012-2016
  • Publications

    Listen to Dr. Mishra's postdoctoral work from Prof. Kai Simons (the membrane master) at:

    http://www.ibiology.org/ibioseminars/cell-biology/kai-simons-part-3.html

    http://www.ibiology.org/ibioseminars-transcripts/Simons_3_English.txt

    1. Bacoside A induces tumor cell death in human glioblastoma cell lines through catastrophic macropinocytosis (2017). Sebastian John, KC Sivakumar and Rashmi Mishra*
      (* corresponding author). Frontiers in Molecular Neuroscience, doi: 10.3389/fnmol.2017.00171
    2. Sebastian John, KC Sivakumar and Rashmi Mishra* (2017). Extracellular proton concentrations impacts LN229 glioblastoma tumor cell fate via differential modulation of surface lipids. Frontiers in Oncology 7:20. doi: 10.3389/fonc.2017.00020 (*corresponding author)
    3. mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain. Sebastian John and Rashmi Mishra*. Frontiers in Molecular Neuroscience 2016 Dec 16;9:139. doi: 10.3389/fnmol.2016.00139 (* corresponding author)
    4. Galectin-9: From Cell Signaling to Complex Disease Dynamics. Sebastian John and Rashmi Mishra*. Journal of Biosciences (2016, in press), (*Corresponding author)
    5. Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. Mishra R, Grzybek M, Niki T, Hirashima M, Simons K. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1012424107. (Highlighted in F1000)
    6. Determination of carbohydrate-binding preferences of human galectins with carbohydrate microarrays. Horlacher T, Oberli MA, Werz DB, Kröck L, Bufali S, Mishra R, Sobek J, Simons K, Hirashima M, Niki T, Seeberger PH. Chembiochem. doi: 10.1002/cbic.201000020.
    7. GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Gupta SK*, Mishra R*, Kusum S, Spedding M, Meiri KF, Gressens P, Mani S. Cell Death Differ. doi: 10.1038/cdd.2008.188. * Equal contribution (Featured article)
    8. Both cell-autonomous and cell non-autonomous functions of GAP-43 are required for normal patterning of the cerebellum in vivo. Shen Y*, Mishra R*, Mani S, Meiri KF. Cerebellum. doi: 10.1007/s12311-008-0049-5.(* equal authors)
    9. GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons. Mishra R, Gupta SK, Meiri KF, Fong M, Thostrup P, Juncker D, Mani S. Cell Cycle. PMID:18235238
  • Team


    Sebastian John, ICMR SRF

    I am studying the clustering induced biomechanical force alterations of the surface membranes and the assembly/disassembly associated signaling kinetics of lipid rafts modules in brain cancers and neural stem cells.

    SAM
    SAM

    Sebastian John, ICMR SRF

    I am studying the clustering induced biomechanical force alterations of the surface membranes and the assembly/disassembly associated signaling kinetics of lipid rafts modules in brain cancers and neural stem cells.

    Vijisha Vijayakumar, Project Fellow

    I am assisting the PI on the elucidation of the role of galectins in the Central Nervous System morphogenesis and tumorigenesis.

    Vijisha Vijayakumar, Project Fellow

    I am assisting the PI on the elucidation of the role of galectins in the Central Nervous System morphogenesis and tumorigenesis.

  • Alumni