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Research

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Alumni

E. Sreekumar, MVSc, PhD

Scientist E-II

+91-471-2529517

esreekumar@rgcb.res.in

sreekumar
sreekumar

E. Sreekumar, MVSc, PhD

Scientist E-II

+91-471-2529517

esreekumar@rgcb.res.in

  • Profile

    • PhD Biotechnology – 2004 (Rajiv Gandhi Centre for Biotechnology)
    • MVSc Immunology – 1996 (Indian Veterinary Research Institute, Izatnagar)
    • 2015-2016 , Visiting Faculty, Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    • 2007-till date, Scientist, Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology
    • 2004-2007, Scientist, Animal Biotechnology Laboratory, Rajiv Gandhi Centre for Biotechnology
    • 1997-1998 , Veterinary Surgeon, Department of Animal Husbandry, Government of Kerala
    • Fulbright-Nehru Academic and Professional Excellence Fellowship (FNAPE) 2015-2016
    • Young Scientist Award, XII National Symposium of Indian Society for Veterinary Immunology and Biotechnology, November 3-4, 2004.
    • Indian Council for Agricultural research (ICAR)-Agricultural Scientist Recruitment Board (ASRB) National Eligibility Test (NET) 1996
    • Gold Medal and Best student award from Indian Veterinary Research Institute (IVRI) (1994-96)
    • CSIR-Senior Research Fellowship
    • Indian Veterinary Research Institute Junior research Fellowship
    • Merit scholarships from Kerala University and Kerala Agricultural University
    • Life Member, Society of Biological Chemists, Bangalore, India

    • Ongoing: 4
    • Completed: 3
  • Research

    Biology of re-emerging Chikungunya virus strains

    Chikungunya is an acute, febrile infection characterized by polyarthralgia. The disease is caused by a positive-stranded RNA virus of the alphavirus genus in the Togaviridae family and transmitted by mosquitoes of the Aedes genus, Ae.aegypti and Ae.albopictus. India has witnessed major outbreaks of the disease during the years 2005-2010, and sporadic infections still continue in many parts of the country. The remerging strains of Chikungunya virus have novel mutations, including the well-studied A226V change in the E1 envelope protein that enhanced the mosquito-adaptability of the virus. The disease caused by these newer strains of the virus were characterized by more severe arthralgia, unusually prolonged duration of the illness and atypical features such as dermatological and neurological complications. Our primary interest is characterization of the molecular changes in these re-emerging Chikungunya viral strains to elucidate their genetic make-up and to correlate the changes with viral replication and infectivity. We also look into the adaptive changes that impart neurovirulence to these viruses using in vitro as well as animal models. Another area of our interest is the development of targeted antiviral assays and screening for the identification of potential inhibitors against these viruses from purified natural products, herbal plant extracts and marine compounds.

    Evolutionary dynamics of Dengue virus in the Indian subcontinent and mechanisms of host-pathogen interaction

    Among the mosquito-borne viral infections, Dengue has emerged as the most important disease affecting millions of people across the world. The disease is caused by any of the four antigenically distinct viruses (Dengue virus serotypes 1-4) belonging to the positive stranded RNA virus family of Flaviviridae. In the Indian subcontinent, Dengue has been prevalent since the last fifty years, and of late, the magnitude of the illness has gone several folds up with unpredictable outcomes. Whereas the Dengue infection in its mild form is self-limiting and sometimes even presented sub-clinically, the dengue with warning signs can become life-threatening if proper clinical care is not given. The clinical severity of the disease is decided by both viral as well as host factors, most of which are yet to be fully characterized. One of our interests is to study the evolutionary biology of the Dengue virus serotypes in the subcontinent using partial as well as whole genome analysis. Earlier studies have pointed to a major role of the strains from India in the global spread and evolutionary dynamics of the virus. We predominantly focus on the isolates from Kerala, a highly dengue endemic state in Southern India, and make comparative analysis of the strains with those isolated from different parts of the country as well as the world. Our aim is to look for viral genotypic changes in the region that might be associated with disease severity. As part of elucidating the host factors involved in pathogenesis, our interest is to explore the molecular mechanisms of vascular leakage, which is a major cause of shock and mortality as a consequence to the infection.

    Extramural Grants

    No.Name of GrantFunding AgencyRoleYearAmount of Grant (Rs.)
    1Characterization of duck RANTES, MIP-1ß&MCP-1 like CC-chemokines with respect to hepadnaviral replicationDepartment of Biotechnology, Govt. of India New Delhi Principal Investigator2007-200923.6 lakhs
    2A molecular drug screen for hepatitis-C: Development of a cell-culture based reporter assay for identifying potential NS3/4A protease inhibitors from medicinal plantsKerala State Council for Science, Technology and Environment, Govt. of KeralaPrincipal Investigator2008-20108.36 lakhs
    3In silico identification of Chikungunya virus (CHIKV) inhibitors from natural product libraries on E1 envelop protein structureDepartment of Biotechnology, Govt. of India , New DelhiPrincipal Investigator200922.32 lakhs
    4Prospecting Zingiber zerumbet for molecular resources Department of Biotechnology, Govt. of India , New DelhiCo- Principal Investigator2010-2013118.47 lakhs
    5Characterization of Neurovirulence of Chikungunya virus in cellular and animal modelsDepartment of Biotechnology, Govt. of India , New DelhiPrincipal Investigator2012-201544.69 lakhs
    6Elucidation of the role of endothelial cell signaling pathways in vascular permeability modulation in Dengue virus infectionIndian Council of Medical Research (ICMR), New DelhiPrincipal Investigator2014-201721.25 lakhs
    • National: Department of Paediatrics, SAT Hospital, Government Medical College, Thiruvananthapuram.
    • International: Central Department of Biotechnology, Tribhuvan University,Kathmandu, Nepal.
  • Publications

    Peer Reviewed Publications:

    2016

    1. Rachy Abraham, AnoopManakkadan, Prashant Mudaliar, Iype Joseph, Krishnankutty Chandrika Sivakumar, Radhakrishnan Reghunathan Nair, Easwaran Sreekumar* (2016). Correlation of phylogenetic clade diversification and in vitro infectivity differences among Cosmopolitan genotype strains of Chikungunya virus.  Infect Gen Evol. 37: 174-184. 

    2015

    1. Sneha Singh, Birendra P Gupta, Anoop Manakkadan, Krishna Das Manandhar, Easwaran Sreekumar* (2015) Phylogenetic study reveals co-circulation of Asian and Cosmopolitan genotypes of Dengue virus serotype 2 in Nepal during 2013. Infect Gen Evol. 34: 402-409. 
    2. Rachy Abraham, Prashant Mudaliar, Abdul Jaleel, Srikanth Jandhyam, Easwaran Sreekumar* (2015). High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection. J Proteomics 120:126- 141 Impact factor 3.931
    3. Birendra Prasad Gupta, Sneha Singh, Roshan Kurmi, Rajani Malla, Easwaran Sreekumar*, Krishna Das Manandhar. Re-emergence of Dengue virus serotype 2 strains in a 2013 epidemic in Nepal. Indian J. Med .Res. (In Press)

    2014

    1. Vijesh S Kuttiatt, Sanughosh Kalpathodi, Sindhu T Gangadharan, Lalitha Kailas, Easwaran Sreekumar, Suja M Sukumaran, Radhakrishnan R Nair (2014) Detection of Measles Virus Genotype B3 in India. Emerg. Inf. Dis. 20, 1764-1765
    2. Konstantin A. Tsetsarkin, Rubing Chen, Ruimei Yun, Shannan L. Rossi, Kenneth S. Plante, Mathilde Guerbois, Naomi Forrester, Guey Chuen Perng, Easwaran Sreekumar, Grace Leal, Jing Huang, Suchetana Mukhopadhyay, Scott C. Weaver (2014) Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. Nature Commun. 5:4084 DOI: 10.1038/ncomms5084
    3. K Krithiga, Divakaran N Nair, E Sreekumar, Mammen J Abraham, Ajith Jacob George, CB Manomohan (2014) Isolation and molecular confirmation of extra-intestinal pathogenic Escherichia coli (ExPEC) from domestic pigs. Indian J Vet. Pathol. 38 (2), 85-87
    4. Sheeba PM, Jose R, Sreekumar E, Vimalraj AN, Kurian S, Bai JTR. A Comparative Study of Dengue Syndromes in a Tertiary Care Centre (2014). Academic Medical Journal of India 2:60–66

    2013

    1. Rachy Abraham, Prashant Mudaliar, Aiswaria Padmanabhan, Easwaran Sreekumar* (2013) Induction of cytopathogenicity in human glioblastoma cells by Chikungunya virus. PLoS ONE 8(9):e75854. doi:10.1371/journal.pone.0075854
    2. Praveen K. Sobhan, Mahendra Seervi, Lokesh Deb, Saneesh Varghese1, Anjana Soman, Jeena Joseph1, Krupa Ann Mathew, Godi Raghu, George Thomas, Sreekumar E, Manjula S, Santosh Kumar T. R (2013). Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis. PLoS ONE 8(4): e59350. doi:10.1371/journal.pone.0059350
    3. Anoop Manakkadan, Iype Joseph, Raji Rajendran Prasanna, Riaz Ismail kunju , Lalitha Kailas, Easwaran Sreekumar* (2013). Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from Kerala. Virol. J. 10(1):37.

    2012

    1. Zinia T Nujum, Vijayakumar K, Pradeep Kumar AS, Anoop M, Sreekumar E, Ramani Bai JT, Dalus D, Lalitha Kailas, Saritha N, Anitha Abraham, Anto Varghese, Raji RT , Sudheesh Kumar TK(2012). Performance of WHO probable case definition of dengue in Kerala, India, and its implications for surveillance and referral. Dengue Bulletin 36: 94-104
    2. M. Anoop , Ashish J. Mathew, B. Jayakumar , Aneesh Issac, Sajith Nair, Rachy Abraham, M.G. Anupriya, E. Sreekumar* (2012). Complete genome sequencing and evolutionary analysis of Dengue virus serotype 1 isolates from an outbreak in Kerala, South India. Virus Genes 45:1-13

    2011

    1. Nair S, Arathy DS, Issac A and Sreekumar E* (2011). Differential gene expression analysis of in vitro duck hepatitis B virus infected primary duck hepatocyte cultures. Virology J. 8:363
    2. C.N. Sreekanth, S.V. Bava, E. Sreekumar; R.J. Anto (2011). Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene 30(28):3139-52
    3. D.S. Arathy, Sajith Nair, Soja Saghar Soman, Aneesh Issac, E. Sreekumar* (2011). Functional characterization of the CC chemokine RANTES from Pekin duck (Anas platyrhynchos). Developmental and Comparative Immunology 35; 142–150

    2010

    1. Niyas KP, Abraham R, Unnikrishnan RN, Mathew T, Nair S, Manakkadan A, Issac A, Sreekumar E* (2010).Molecular characterization of Chikungunya virus isolates from clinical samples and adult Aedes albopictus mosquitoes emerged from larvae from Kerala, South India. Virology J. 7(1):189.
    2. Anoop, M; Aneesh Issac; Thomas Mathew; Sairu Philip; Nabeel Abdul Kareem; Unnikrishnan, R; Sreekumar E* (2010). Genetic characterization of dengue virus serotypes causing concurrent infection in an outbreak in Ernakulam, Kerala, South India. Ind. J. Exp. Biol. 48 (08):849-857
    3. Soman SS, Sivakumar KC, Sreekumar E* (2010).Molecular dynamics simulation studies and in vitro site directed mutagenesis of avian beta-defensin Apl_AvBD2. BMC Bioinformatics. 11 Suppl 1:S7.
    4. Sreekumar E*, Issac A, Nair S, Hariharan R, Janki MB, Arathy DS, Regu R, Mathew T, Anoop M, Niyas KP, Pillai MR (2010).Genetic characterization of 2006-2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysis. Virus Genes. 40(1):14-27.

    2005-2009

    1. Soman SS, Nair S, Issac A, Arathy DS, Niyas KP, Anoop M, Sreekumar E*. (2009) Immunomodulation by duck defensin, Apl_AvBD2: in vitro dendritic cell immunoreceptor (DCIR) mRNA suppression, and B- and T-lymphocyte chemotaxis. Mol Immunol. 46(15):3070-5
    2. Soman SS, Arathy DS, Sreekumar E* (2009). Discovery of Anas platyrhynchos avian beta-defensin 2 (Apl_AvBD2) with antibacterial and chemotactic functions. Mol Immunol. 46(10):2029-38.
    3. B. M. Viola, T. E. Abraham, D. S. Arathi, E. Sreekumar, M. R. Pillai, T. J. Thomas, C. K. S. Pillai (2008) Synthesis and characterization of novel water-soluble polyamide based on spermine and aspartic acid as a potential gene delivery vehicle eXPRESS Polymer Letters 2 (5): 330–338
    4. Sreekumar E*<, Janki MB, Arathy DS, Hariharan R, Premraj CA, Rasool TJ.(2007) Molecular characterization and expression of Interferon – gamma of Asian elephant (Elephas maximus). Vet Immunol Immunopathol. 118: 75-83
    5. T J Rasool, M Hosamani, A Premraj, E Sreekumar and R K Singh (2006) Ovine interferon-gamma gene of indigenous sheep: Cloning, sequencing and expression studies in Escherichia coli. Indian J. Biotechnol 5: 486-490
    6. Avinash Premraj, E.Sreekumar, Mamta Jain & T.J. Rasool (2006) Buffalo (Bubalus bubalis) Interleukin-12: analysis of expression profiles and functional cross-reactivity with bovine system. Mol. Immunol 43 (7): 822-9
    7. Sunil Kumar, M., Bikash Sahay, Abi George Aleyas, Hira Ram, Bimalendu Mondal, Binita Nautiyal, Avinash Premraj, E. Sreekumar, M.P.Yadav & T.J.Rasool (2006). Inhibition of Anatid Herpes Virus-1 replication by small interfering RNAs in cell culture system. Virus Res. 115(2):192-7
    8. Avinash Premraj, E.Sreekumar & T. J. Rasool (2006). Cloning and biological characterization of buffalo (Bubalus bubalis) interferon- gamma. Mol. Immunol. 43 (6):717-24
    9. Avinash Premraj, E. Sreekumar, Binita Nautiyal and T.J.Rasool (2006) Molecular characterization and prokaryotic expression of Buffalo (Bubalus bubalis) Interleukin-6 Mol. Immunol. 43 (3):202-9
    10. E.Sreekumar, Avinash Premraj & T.J. Rasool (2005) Duck (Anas platyrhynchos), Japanese quail (Coturnix coturnix japonica) and other avian Interleukin-2 reveal significant conservation of gene organization, promoter elements and functional residues. International Journal of Immunogenetics 32 (6):355-365
    11. E.Sreekumar, Avinash Premraj, Arathy D.S & T. J. Rasool (2005). Identification, sequence characterization and analysis of expression profiles of three novel CC chemokines from domestic duck (Anas platyrhynchos). Immunogenetics 57: 364-373
    12. Avinash Premraj, E. Sreekumar, Binita Nautiyal and T.J. Rasool (2005). Molecular cloning and expression profile analysis of interleukin-10 and interleukin-18 cDNA of Indian water buffalo (Bubalus bubalis). Vet Immunol Immunopathol. 107:337-347
    13. Aviansh Premraj, Sreekumar E , Binita Nautiyal and Rasool, T.J. (2005). Interleukin-12 subunits p35 and p40 of Indian water buffalo (Bubalus bubalis) maintain high sequence homology with that of other ruminants. International J. Immunogenetics 32: 179-186

    2002-1999

    1. Sreekumar E, Avinash Premraj, Saravanakumar, M. and Rasool, T.J. (2002). Buffalo interleukin–2: Sequence analysis reveals high nucleotide and amino acid identity with interleukin-2 of cattle and other ruminants. European J. Immunogenetics 29 (4): 341-345.
    2. Sreekumar E and Das, S.K. (2001). Mycobacterium phlei as an oral immunomodulator with Newcastle disease vaccine. Indian J. Exp. Biol. 39: 989-992.
    3. Rasool, T.J., Dechamma, H.J. and Sreekumar.E (2000). A common method for MHC typing of farm animals using PCR-RFLP. Indian J. Animal Sci. 70: 716-717.
    4. Sreekumar.E and Das, S.K. (2000). Activation of chicken intestinal Intraepithelial lymphocytes by oral administration of M.phlei. Indian J. Animal Sci. 70: 1204-1207
    5. Sivarama, K.R.P., Sreekumar.E and Rasool, T.J. (1999).Cloning and sequencing of truncated gIV glycoprotein gene of an Indian isolate of BHV-1.Acta Virologica 43: 387-389.

    (* as corresponding author)

    Poster Presentation

    1. Molecular and evolutionary analysis of dengue virus serotype 2 in Nepal during 2013 outbreak; Sneha Singh, Birendra Prasad Gupta*, Anoop Manakkadan, KD Manandhar*, E Sreekumar ; 12th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases;11-13 December, 2014, Bangkok
    2. Genetic diversity of dengue virus serotype-2 Genotype IV (Cosmopolitan) strains in South India during 2008-2012; M. Anoop, M.G. Anupriya, Sneha Singh, K.C. Sivakumar, E. Sreekumar; 12th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases;11-13 December, 2014, Bangkok
    3. Dissection of Host-virus Interactions in Chikungunya Using Expression Proteomics Analysis; Rachy Abraham, K.A. Abdul Jaleel, E. Sreekumar; 16th International Congress of Virology IUMS 2014 in Montreal, Canada ; 27 July, 2014 to 01 August, 2014
    4. Genetic Characterization of the Dengue Virus serotype 2 isolates from Kerala (2008-11) Anoop M.,Sreekumar E., International Conference on Dengue and Emerging Infections, on 21-23rd Nov.,2012, Singapore.
    5. Dengue surveillance in Kerala, south-India, from 2007-2010: a laboratory based analysis. Anoop.M, Rachy Abraham and E. Sreekumar, International Meeting on Emerging Diseases and Surveillance (IMED) 2011, 4-7th Feb. 2011 held at Vienna, Austria
    6. Detection of a concurrent dengue virus infection during an outbreak in Ernakulam, Kerala by RT-PCR. Anoop.M, Thomas Mathew and E. Sreekumar , 3rd National Conference on Infectious Diseases, 17-18th April 2010 held at AIIMS, New Delhi
    7. Comparison of the in vitro infectivity pattern among the genetically characterized isolates of Chikunguniya Virus from 2006-2008 outbreaks in Kerala. Rachy Abraham and E. Sreekumar 3rd National Conference on Infectious Diseases, 17-18th April 2010 held at AIIMS, New Delhi

    Participation

    1. 2nd International Conference on Dengue and Dengue Haemorrhagic Fever, Global Innovation to Fight Dengue Oct 15-17th, 2008, Phuket, Thailand

    Invited Talk/ Oral Presentation

    1. Scourges on a stroll: emerging viral infections, In: National Seminar on Advances in Biotechnology, Decemebr 15-16, 2015; Cochin University of Science and Technology (CUSAT), Kerala
    2. Chikungunya- Will the past be the future? In National Symposium on Human Diseases, March 15-16, Birla Institute of Technology and Science, Pilani, Hyderabad Campus
    3. Changing Molecular Profiles of Re-emerging Arboviruses in India. Third Annual Conference of International Association of Medical and Pharmaceutical Virologists (IAMPV) on “Challenges and Strategies in the Prevention and Management of Viral Infections” on 9th and 10th November 2012, Chennai, India
    4. Clinical and Virological profile of a hospital-associated Dengue outbreak in 2009 in Thiruvananthapuram, Kerala. 3rd National Conference on Infectious Diseases at All India Institute of Medical Sciences(AIIMS), New Delhi on 17th -18th April, 2010.
    5. Analysis of a Dengue Fever Outbreak Caused by Denv-1 in Medical College Campus, Trivandrum, Kerala. Jayakumar B, Mathew AJ, Divya S, Sheeba PM, Sreekumar E. Presented at : 65th Annual Conference of Association of Physicians of India (APICON 2010), 7-10th, 2010 at Jaipur, Rajasthan, India
    6. Genetic Changes in Chikungunya Virus in Kerala. Sreekumar E. In National Work Shop on Emerging Fevers with focus on Chikungunya; December 28th, 2007 organized by National Rural Health Mission (Kerala) at Ernakulam, Kerala
    7. Genetic changes in emerging mosquito-borne viruses: implications in disease Pathogenesis. Sreekumar E. ; in the National Seminar on “Emerging and Re-emerging infectious Diseases” on October 26th, 2007 at Kerala State Council for Science & Technology, Thiruvananthapuram, Kerala
  • Team


    Rachy Abraham, Senior Research Fellow (INSPIRE)

    Characterization of the immunopathogeneis of Chikungunya infection

    A new drug discovery paradigm for managing infectious diseases has emerged that, in contrast with conventional pathogen – targeting strategies, focus on identifying and targeting those hijacked host factors which are exploited by pathogens for its survival and growth in a hostile cellular environment. My work will focus on studying the host /virus interaction during chikungunya infection, and aims to identify the role of innate immune response mediators and receptors involved in anti-viral responses.

    rachy
    rachy

    Rachy Abraham, Senior Research Fellow (INSPIRE)

    Characterization of the immunopathogeneis of Chikungunya infection

    A new drug discovery paradigm for managing infectious diseases has emerged that, in contrast with conventional pathogen – targeting strategies, focus on identifying and targeting those hijacked host factors which are exploited by pathogens for its survival and growth in a hostile cellular environment. My work will focus on studying the host /virus interaction during chikungunya infection, and aims to identify the role of innate immune response mediators and receptors involved in anti-viral responses.

    Mudaliar Prasanth Pandurang, Junior Research Fellow (UGC)

    Evaluation of CHIKV inhibitory activity of natural products in cell-based and animal models

    The re-emergence of chikungunya (CHIK) has generated a need to evolve control measures including therapeutic and vaccination strategies. This is also necessitated by the fact that unusual complications, along with suspected incidences of mortality, were observed in recent outbreaks with this virus, infection with which is otherwise considered benign. Major aim of my work will be the evaluation of chikungunya virus inhibitory activity of natural products using whole virus and replicon systems in cell-based and animal models.

    prasanth1
    prasanth1

    Mudaliar Prasanth Pandurang, Junior Research Fellow (UGC)

    Evaluation of CHIKV inhibitory activity of natural products in cell-based and animal models

    The re-emergence of chikungunya (CHIK) has generated a need to evolve control measures including therapeutic and vaccination strategies. This is also necessitated by the fact that unusual complications, along with suspected incidences of mortality, were observed in recent outbreaks with this virus, infection with which is otherwise considered benign. Major aim of my work will be the evaluation of chikungunya virus inhibitory activity of natural products using whole virus and replicon systems in cell-based and animal models.

    Anupriya MG, Senior Research Fellow (ICMR)

    Molecular studies on alterations in vascular permeability during Dengue Shock Syndrome

    Sudden and extensive plasma leakage into tissue spaces and various serous body cavities in patients with dengue hemorrhagic fever may lead to dengue shock syndrome that can be fatal. Plasma leakage in dengue occurs with a relative lack of tissue inflammation, suggesting that a transient change in factors that regulate vascular permeability in the physiological state may be the mechanism of plasma leakage in this disease. My aim is to understand these molecular changes in severe dengue.

    Anupriya M G
    Anupriya M G

    Anupriya MG, Senior Research Fellow (ICMR)

    Molecular studies on alterations in vascular permeability during Dengue Shock Syndrome

    Sudden and extensive plasma leakage into tissue spaces and various serous body cavities in patients with dengue hemorrhagic fever may lead to dengue shock syndrome that can be fatal. Plasma leakage in dengue occurs with a relative lack of tissue inflammation, suggesting that a transient change in factors that regulate vascular permeability in the physiological state may be the mechanism of plasma leakage in this disease. My aim is to understand these molecular changes in severe dengue.

    Sneha Singh, DST-INSPIRE Fellow

    Dengue virus biology: Elucidating endothelial cell signaling pathway alterations in vascular leakage induced by dengue virus.

    Dengue is an emerging threat in tropical and sub-tropical countries with more than 2, 50, 000 cases reported per year. The severe cases of infection lead to plasma leakage and shock syndrome. The ultimate player in regulating the vascular leakage is the endothelial cells which has a critical role in leakage, inflammation and vascular repair. My work will focus to understand the endothelial cell signaling pathways involved in the regulation of vascular leakage in dengue infection and study the viral determinants involved in manipulating these pathways.

    Sneha Singh
    Sneha Singh

    Sneha Singh, DST-INSPIRE Fellow

    Dengue virus biology: Elucidating endothelial cell signaling pathway alterations in vascular leakage induced by dengue virus.

    Dengue is an emerging threat in tropical and sub-tropical countries with more than 2, 50, 000 cases reported per year. The severe cases of infection lead to plasma leakage and shock syndrome. The ultimate player in regulating the vascular leakage is the endothelial cells which has a critical role in leakage, inflammation and vascular repair. My work will focus to understand the endothelial cell signaling pathways involved in the regulation of vascular leakage in dengue infection and study the viral determinants involved in manipulating these pathways.

    Sreeja R Nair, PhD Student

    Chikungunya Virus Biology: Molecular alterations in central nervous system (CNS) in mouse models of Chikungunya virus neurovirulence

    In recent outbreaks of Chikungunya, increased incidences of neurological complications were reported. However, our understanding of the neurotropism of the virus and associated viral pathogenesis in brain remains poorly characterized. My aim is to study the alterations in CNS imparted by the neuroinvasive strains of CHIKV using animal models and to perceive the underlying molecular mechanisms of neurovirulence.

    sreeja
    sreeja

    Sreeja R Nair, PhD Student

    Chikungunya Virus Biology: Molecular alterations in central nervous system (CNS) in mouse models of Chikungunya virus neurovirulence

    In recent outbreaks of Chikungunya, increased incidences of neurological complications were reported. However, our understanding of the neurotropism of the virus and associated viral pathogenesis in brain remains poorly characterized. My aim is to study the alterations in CNS imparted by the neuroinvasive strains of CHIKV using animal models and to perceive the underlying molecular mechanisms of neurovirulence.

    Unnikrishnan V R, Technical Assistant

    lekshmi2
    lekshmi2

    Unnikrishnan V R, Technical Assistant

  • Alumni


    Arathy D S, PhD

    Completed PhD in 2010
    Present address: Department of Diagnostic Medicine / Pathobiology, College of Veterinary Medicine, Kansas State University
    E-mail: arathy@vet.k-state.edu

    aarathy
    aarathy

    Arathy D S, PhD

    Completed PhD in 2010
    Present address: Department of Diagnostic Medicine / Pathobiology, College of Veterinary Medicine, Kansas State University
    E-mail: arathy@vet.k-state.edu

    Soja Saghar Soman, PhD

    Completed PhD in 2010
    Present address: Biotechnology Laboratories, Department of President's Affairs, United Arab Emirates
    E-mail: sojasagharsoman@ dopa.ae

    soja
    soja

    Soja Saghar Soman, PhD

    Completed PhD in 2010
    Present address: Biotechnology Laboratories, Department of President's Affairs, United Arab Emirates
    E-mail: sojasagharsoman@ dopa.ae

    Anoop M, PhD

    Completed PhD in 2014
    Present Address: Department of Biotechnology, Cochin University of Science & Technology
    E-mail: anoopm_83@yahoo.co.in

    anoop
    anoop

    Anoop M, PhD

    Completed PhD in 2014
    Present Address: Department of Biotechnology, Cochin University of Science & Technology
    E-mail: anoopm_83@yahoo.co.in