Sabira Mohammed, PhD Scholar (ICMR-SRF)
The role of SphK1/S1P axis in innate immune response
The principal objective of my study is to determine the role played by SphK1/S1P axis in host defense strategy. The innate immune system provides the first line of defense against invading pathogens. This is accomplished by recognising Pathogen Associated Molecular Patterns (PAMPs) by Pattern Recognition Receptors (PRRs). Of the PRRs, TLRs are the most widely studied. The interaction between activation of TLR by PAMP and the SphK1-S1P-S1PR axis needs further investigation to recognize role of S1P in immunity.