The current work revolves around the disease, leptospirosis. An epidemiological approach is taken to understand the transmission dynamics between man and various mammals, the role of environment and the dynamic relations between these. The relation between severity of disease, leptospiral serovars, carrier hosts, climate, geographical location and potential for exposure are being studied. The genetic basis for persistence of serovars in different geographical areas is proposed to be studied.
Among the reported causes of mortality in Kerala due to communicable diseases, Leptospirosis contributes the maximum fraction for the past many years. Humans and animals may become infected through direct contact with contaminated urine or indirectly through exposure to contaminated water or soil. Rats and mice have been known to be carriers and transmit the maximum number of serovars. The abundance of the various natural hosts in areas of human habitation and occupation determines the potential for transmission for leptospira. By studying these, a rational basis for the control of leptospira is expected to be prepared