Aswathy P M, Post Doctoral Fellow
Genetics of Dementia
My work focuses on genetics of dementia. I intend to develop a susceptibility profile of genetic biomarkers that can reliably identify individuals well in advance of clinical manifestation as well as during the disease progression, in order to have a maximum impact on improving cognitive function and quality of life. Currently there is no pharmacological treatment to stop or reverse the neurodegeneration in dementia. Researchers are underway to determine the genetic cause and then the pathogenic basis to develop proper therapeutic trials. So the rationale for the proposed work is that, the identification of the genetic etiological factor is essential to adopt appropriate interventional strategies. The central hypothesis is that a combination of genetic (including the genes involved in inflammation, autophagy as well as genetic mutations) and environmental risk factors (oxidative stress) might be directly or indirectly responsible for pathogenesis in Alzeimer Disease and Fronto Temporal Dementia in our population.