Profile

Research

Publications

Team

Alumni

Moinak Banerjee, PhD

Scientist F

+91-471-2529529

mbanerjee@rgcb.res.in

moinak
moinak

Moinak Banerjee, PhD

Scientist F

+91-471-2529529

mbanerjee@rgcb.res.in

  • Profile

    • PhD – (1987 – 92) (M.L.Sukhadia University, Udaipur)
    • MSc – (1985 – 87) (Dr.H.S.Gaur University, Sagar)
    • BSc – (1982 – 85) (Bhopal University, Bhopal)
    • Since 1996, Scientist, Rajiv Gandhi Center for Biotechnology, Trivandrum
    • Post Doctoral Fellow, Centre for Cellular and Molecular Biology, Hyderabad
    • Post Doctoral Fellow, All India Institute of Medical Sciences, New Delhi

    Fellowships

    • CBOL Travel Fellowship to attend the Regional meeting and International Conference on Barcoding, Academia Sinica, Taiwan .
    • (1987 – 92) CSIR Fellowship for JRF/SRF
    • (1992 – 94) CSIR Fellowship for RA
    • (1994 – 96) CZA Fellowship for PDF
    • 1991 Training fellowship to Cold Spring Harbor Laboratory (CSHL), New York, USA
    • 1999 International fellowship to Brain Science Institute (BSI), RIKEN, Tokyo, Japan

    Awards and honors

    • Young Scientist Award on Population Genetics. Indian Soc. of Human Genetics. India (2002). Anitha A.
    • Summer Training Fellowship. RIKEN Brain Science Institute, Tokyo, Japan (2002). Anitha A.
    • Best trainee award on expression technologies. AIIMS, New Delhi (2003). Rasmi Thomas.
    • Young Scientist Appreciation Award on Population Genetics. Indian Soc. of Human Genetics. India (2004). Rasmi Thomas.
    • CSIR travel grant for 54th Annual meeting of ASHG. American Society of Human Genetics, Toronto Canada (2004). Rasmi Thomas.
    • ASHI travel award for 14th International HLA and Immunogenetics Workshop and 35th Australasian Society of Immunology conference, Melbourne, Australia (2005). Rasmi Thomas.
    • HUGO-AP travel award for Joint 6th Human Genome Organization (HUGO) Pacific Meeting & 7th Asia-Pacific Human Genetics Conference, Taiwan (2006). Neetha N.V.
    • Best Poster Award XXII Annual Conference of Indian Society of Human Genetics, Kolkata (2007). Linda Koshy V.
    • Summer Training Fellowship. RIKEN Brain Science Institute, Tokyo, Japan (2007). Neetha N.V.
    • CBOL travel award for 2nd International Barcode of Life Conference, Taiwan from September 17th- 21st (2007). Chandrasekhar N.
    • International Society for Psychiatric Genetics Travel grant for World Congress on Psychiatric Genetics, Newyork, October 7th -11th (2007). Neetha N.V.
    • Member, Assoc. of DNA Fingerprinting and Allied Technologies (ADNAT)
    • Member, Indian Society of Human Genetics (ISHG)
    • Member, American Society of Human Genetics (ASHG)
    • Member, International Genetic Epidemiology Society (IGES)
    • Member, SACNET a regional loop of BIONET International.

    Editorial and academic Assignment

    • Associate Editor, J of Genetics, Indian Academy of Science, Elsevier Publication.
    • Guest editor, Special issue on Pharmacogenetics, Indian J of Human Genetics.
    • Editorial Board member, Indian J of Human Genetics
    • Academic Council member, Kalasalingam Univ.,Krishnankoil (TN)
    • Adjunct Professor Institute for Communicative and Cognitive Neurosciences, (ICCONS), Shoranur.
    • Visiting Professor Kalasalingam University, Krishnankoil. (TN)
    • Guest faculty, National Institute of Speech and Hearing, Trivandrum.
    • Doctoral committee member, Vellore Institute of Technology, Vellore.
    • Doctoral committee member, SCTIMST, Trivandrum
    • Doctoral committee member, NIMHANS, Bangalore.
    • Vice President, Indian Society of Human Genetics.(ISHG)
    • Convenor of OUTREACH program of Indian Society of Human Genetics for South Asian countries.
  • Research

    Human Molecular Genetics with specific reference

    • Microsatellite Genetics
    • Pharmacogenetics
    • Immunogenetics
    • Ecological genetics

    Indian population is divided into several endogamous groups consisting of 4635 different communities with hierarchical caste structure. The basis of reproductive isolation of these populations is also highly varied, comprising of geographic, religious, ethnic or occupational backgrounds.

    The main concern of our research is to search for the extent of genetic variability in ethnic communities and also search for ethnically predisposed variants for the various diseases under study. The population biology approaches would contribute to the understanding of infectious diseases and design and evaluation of intervention for their treatment and prevention. This is done by DNA fingerprinting profiling, Immunogenetic profiling and pharmacogenetic profiling. Linkage mapping strategies are also being carried out to identify the predisposed allele in a diseased individual.

    Presently diseases like Schizophrenia, Ankylosing spondylitis, Intracranial aneurysm and Cancer are being investigated. In return this would help us in the identification and characterization of population level processes and structures, which contribute to the emergence, and maintenance of disease. I get involved in various diseases because of my clinical collaborators’ sincere involvement with their patients.

    PhD Thesis

    • Molecular signatures of Tribal Populations in Kerala based on DNA Finger printing. Anitha, A. 2002
    • Immunogenetic Profiling and Disease Association of HLA Class India 1 Genes in different population of Kerala. Rashmi Thomas. 2005.
    • Population dynamics, molecular phylogeny and charecterization of antimicrobial peptides of teak defoliator ( Hyblae puera carmer). Chandrasekhar, R 2007
    • Pharmacogenetic Profiling for Theranostic Evaluation of Schizophrenla in a South Indian Population. Neetha N V. 2009.
    • Genetic Dissection of Intracranial Aneurysms in South Indian Population. Linda Koshy Vaidyan. 2009.

    Co-Guide: PhD

    • Pharmacogenetic study to evaluate the teratogenic effects of antiepileptic drugs. Manna Jose. SCTIMST, 2010
    • An inquiry into the Molecular Genetics of Pharmacoresistant Epilepsy. Shabeesh Balan. 2012.

    MD Thesis

    • Tracing of disease genes in Non-syndromic clefts of orofacial region: An analysis into the nature of genetic defect. Dr. Saleem Faiz Shaikh. Govt. Dental College, Calicut. 2006
    • A conceptual study on prakriti correlation with molevular profiles. Dr. K.N.AjithKumar, Govt. Ayurveda college, Kannur. 2007
    • Genetic profiling of a cohort of Areca-nut associated Oral submucous Fibrosis: An analysis of Transforming growth factor beta-1 (TGF-b1) polymorphism. Harish RK, Master of Dental surgery, Govt. Dental college, Trivandrum. 2008
    • Genetic profiling of a cohort of Areca-nut associated Oral submucous Fibrosis: An analysis of Transforming growth factor beta-1 (TGF-b1) polymorphism. Vijay Biradar, Master of Dental surgery, Govt. Dental college, Trivandrum. 2008
    • Interleukin gene polymorphism in periodontitis. Dr. Abhijit Shete. Master of Dental surgery, Govt. Dental college, Calicut. 2009.
    • Role of Integrin Subfamily (alpha 4 beta1) in facilitating leucocyte recruitment in Oral submucous Fibrosis. Dr. Deepthi K. Master of Dental surgery, Govt. Dental college, Trivandrum. 2009.
    • Role of Basic fibroblast growth factor as an angiomodulator in Oral submucous Fibrosis. Dr. Pradeesh Balan. Master of Dental surgery, Govt. Dental college, Trivandrum. 2009.
    • Microsatellite instability in oral squamous cell carcinoma with reference to tumor suppressor genes. Dr. Sivakumar R, Master of Dental surgery, Govt. Dental college, Trivandrum. 2010.
    • Role of microsatellites flanking the MSH2 gene in oral squamous cell carcinoma. Dr. Swagatika Panda. Master of Dental surgery, Govt. Dental college, Trivandrum. 2010.
    • Association of cytokine gene polymrphisms with periodontal disease. Dr. Lekshmi Sreenagesh, Master of Dental surgery, Govt. Dental college, Trivandrum. 2010.
    • Association of cytokine gene polymrphisms with oral lichen planus. Dr. Isha Chauhan, Master of Dental surgery, Govt. Dental college, Trivandrum. 2010.
  • Publications

    1. Sanish Sathyan, Linda V Koshy, Lekshmi Srinivas, Easwer HV, Premkumar S, Suresh Nair, R.N. Bhattacharya, Jacob P Alapatt, Moinak Banerjee (2015) Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by co-morbid factors. J of Neuroinflammation 2015, 12:135
    2. Choudhary, K, Sathyan, S, Beena, VT, Panda, S, Sivakumar, R, Ahuja, A, Banerjee, M. (2015). Polymorphic variants of mismatch repair gene human MutS homologue-2 influence oral squamous cell carcinoma in a South Indian population. Clinical Cancer Investigation Journal, 4(2), 170-174
    3. Panda, S., Beena, V., Sivakumar, R., Choudhary, K., Nalinakumari, K., Sathyan, S., Banerjee, M. (2015). Microsatellite instability in D2S123 flanking the hMSH2gene in oral squamous cell carcinoma in South India. Clinical Cancer Investigation Journal 4(1), 22-28
    4. Sathyan, S., Koshy, L., Balan, S., Eashwer, H. V., Premkumar, S., Nair, S., Bhattacharya, R. N., Allapat, P. J., Banerjee, M. (2014). Association of Versican (VCAN) gene polymorphism rs251124 and rs2287926 (G428D), with intracranial aneurysm. Meta Gene 2, 651-660.
    5. Sharma, N., Joseph, R., Arun, R., Chandni, R., Srinivas, K. L., Banerjee, M. (2014). Cytokine gene polymorphism (interleukin-1beta +3954, Interleukin-6 [-597/-174] and tumor necrosis factor-alpha -308) in chronic periodontitis with and without type 2 diabetes mellitus. Indian J Dent Res, 25(3), 375-380.
    6. Jose, M, Banerjee, M, Mathew, A, Bharadwaj, T, Vijayan, N, Thomas, S. (2014). Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy. The Annals of Indian Academy of Neurology, 17(3), 259-266
    7. Saradalekshmi, K. R., Neetha, N. V., Sathyan, S., Nair, I. V., Nair, C. M., Banerjee, M. (2014). DNA Methyl Transferase (DNMT) Gene Polymorphisms Could Be a Primary Event in Epigenetic Susceptibility to Schizophrenia. PLOS ONE, 9, e98182.
    8. Paul, B., Saradalekshmi, K., Alex, A. M., Banerjee, M. (2014). Circadian rhythm of homocysteine is hCLOCK genotype dependent. Molecular Biology Reports, 41, 3597-3602.
    9. Balan, S., Bharathan, S. P, Vellichirammal, N. N., Sathyan, S., Joseph, V., Radhakrishnan, K. and Banerjee, M. (2014). Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance.PLOS ONE 9(2): e89253
    10. Sathyan, S., Koshy, L., Lekshmi, K.S., Easwer, H., Premkumar, S., Alapatt, J.P., Nair, S., Bhattacharya, R., Banerjee, M. (2013). Lack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population. Molecular Biology Reports 40, 5869-5874.
    11. Balan, S., Sathyan, S., Radha, S.K., Joseph, V., Radhakrishnan, K., Banerjee, M. (2013). GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures. Pharmacogenetics and Genomics 23, 605-610.
    12. Jain, N., Joseph, R., Balan, S., Arun, R., and Banerjee, M. (2013). Association of interleukin-4 and interleukin-17F polymorphisms in periodontitis in Dravidian ethnicity. Indian Journal of Human Genetics 19, 58-64.
    13.  Balan, S., Radha, S.K., Sathyan, S., Vijai, J., Banerjee, M., and Radhakrishnan, K. (2013). Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. Gene 526, 449-453.
    14. Chauhan, I., VT, B., Srinivas, L., Sathyan, S., and Banerjee, M. (2013). Association of Cytokine Gene Polymorphisms with Oral Lichen Planus in Malayalam-Speaking Ethnicity from South India (Kerala). Journal of Interferon & Cytokine Research 33, 420-427.
    15. Balan, S., Vellichirammal, N.N., Banerjee, M., and Radhakrishnan, K. (2012). Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy Research 101, 288-292.
    16. Vijayan, N.N., Mathew, A., Balan, S., Natarajan, C., Nair, C.M., Allencherry, P.M., and Banerjee, M. (2012). Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective. Pharmacogenomics 13, 1119-1127.
    17. Shaikh, S., Ravenndranath, R., Banerjee, M., Joseph, A., and Jahgirdar, P. (2012). Evidence for transforming growth factor–beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent. Medicina Oral, Patología Oral y CirugíaBucal 17, e197. 
    18. Das, A., Balan, S., Mathew, A., Radhakrishnan, V., Banerjee, M., and Radhakrishnan, K. (2011). Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene? Indian Journal of Human Genetics, 17, 4, 41-47.
    19. Das, A., Balan, S., Banerjee, M., and Radhakrishnan, K. (2011). Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective. Indian Journal of Human Genetics, 17, 4,12-21.
    20. Banerjee, M. (2011). Is pharmacogenomics a reality? Challenges and oppurtunities for India. Indian Journal of Human Genetics, 17, 4, 1-3.
    21. Koshy, L., Easwer, H., Premkumar, S., Alapatt, J.P., Pillai, A.M., Nair, S., Bhattacharya, R., and Banerjee, M. (2010). Risk factors for aneurysmal subarachnoid hemorrhage in an Indian population. Cerebrovascular Diseases 29, 268-274.
    22. Shete, A.R., Joseph, R., Vijayan, N.N., Srinivas, L., and Banerjee, M. (2010). Association of single nucleotide gene polymorphism at interleukin-1β+ 3954,-511, and-31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity. Journal of Periodontology 81, 62-69.
    23. Rajendran, R., Harish, R., Anil, S., Vidyadharan, R., and Banerjee, M. (2010). Transforming growth factor-β-1 polymorphisms are infrequent but exist at selected loci in oral submucous fibrosis. Indian Journal of Dental Research 21, 413-419.
    24. Vijayan, N.N., Iwayama, Y., Koshy, L.V., Natarajan, C., Nair, C., Allencherry, P.M., Yoshikawa, T., and Banerjee, M. (2009). Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population. Journal of Human Genetics 54, 538-542.
    25. Vahab, S.A., Sen, S., Ravindran, N., Mony, S., Mathew, A., Vijayan, N., Nayak, G., Bhaskaranand, N., Banerjee, M., and Satyamoorthy, K. (2009). Analysis of genotype and haplotype effects of ABCB1 (MDR1) polymorphisms in the risk of medically refractory epilepsy in an Indian population. Drug Metabolism and Pharmacokinetics 24, 255-260.
    26. Moinak Banerjee. (2009) Challenges in understanding complex disorders: A Neurogenetic perspective. Reviews in Neurology 1-6.
    27. Natarajan, C., Vijayan, N.N., Vaidyan, L.K., Mathew, A., Srinivas, L., and Banerjee, M. (2008). Universal protocol for generating 100bp size standard for endless usage. Electronic Journal of Biotechnology 11, 126-129.
    28. Koshy, L., Easwer, H., Neetha, N., Natarajan, C., Bhattacharya, R., and Banerjee, M. (2008). Role of endothelial nitric oxide synthase gene polymorphisms in predicting aneurysmal subarachnoid hemorrhage in South Indian patients. Disease markers 24, 333-339
    29. Chandrasekhar, N., Neetha, N., Vaidyan, L.K., and Banerjee, M. (2008). Deciphering the Molecular Phylogenetics of Family Hyblaeidae and Inferring the Phylogeographical Relationships Using DNA Barcoding. Journal of Genetics and Molecular Biology 19, 158-167.
    30. Vijayan, N.N., Bhaskaran, S., Koshy, L.V., Natarajan, C., Srinivas, L., Nair, C.M., Allencherry, P.M., and Banerjee, M. (2007). Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population. Behavior Brain Function 3, 34.
    31. Chandrasekhar, N., Neetha, N., Vaidyan, L.K., and Banerjee, M. (2007). RAGEP Marker System (RAGEP) and Its Validation: A Novel Approach to Assess Insect Biodiversity. Journal of Genetics and Molecular Biology 18, 124-130.
    32. Thomas, R., Philip, J., and Banerjee, M. (2006). Association of an extended haplotype of HLA class I alleles and their flanking microsatellites with spondyloarthropathies in South Indian patients. Human Immunology 67, 318-323.
    33. Thomas, R., Nair, S., and Banerjee, M. (2006). A crypto‐Dravidian origin for the nontribal communities of South India based on human leukocyte antigen class I diversity. Tissue antigens 68, 225-234.
    34. Roshna, T., Thomas, R., Nandakumar, K., and Banerjee, M. (2006). A case-control study on the association of human leukocyte antigen-A* 9 and-B* 15 alleles with generalized aggressive periodontitis in an Indian population. Journal of Periodontology 77, 1954-1963.
    35. Koshy, L.V., Easwer, H., Bhattacharya, R., and Banerjee, M. (2006). Lack of association of Endoglin insertion polymorphism in intracranial aneurysm in South Indian population. Indian Journal of Human Genetics 12, 111-115.
    36. Thomas, R., and Banerjee, M. (2005). HLA-A allele frequency and haplotype distribution in the Dravidian tribal communities of South India. Indian Journal of Human Genetics 2, 3, 111-115.
    37. Chandrasekhar, N., Sajeev, T., Sudheendrakumar, V., and Banerjee, M. (2005). Population dynamics of the teak defoliator (Hyblaeapuera Cramer) in Nilambur teak plantations using Randomly Amplified Gene Encoding Primers (RAGEP). BMC ecology 5, 1.
    38. Thomas, R., Nair, S., and Banerjee, M. (2004). HLA‐B and HLA‐C alleles and haplotypes in the Dravidian tribal populations of southern India. Tissue antigens 64, 58-65.
    39. Thomas, R., Nair, R.C., Nandakumar, K., and Banerjee, M. (2004). Association of HLA-A^* 9 and A^* 10 with Aggressive Periodontitis in South India. International Journal of Human Genetics 4, 137-140
    40. Anitha, A., Bhattacharya, R.N., Radhakrishnan, V.V., and Banerjee, M. (2004). Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors. Journal of Carcinogenesis 3, 11.
    41. Anitha, A., and Banerjee, M. (2003). Arylamine N-acetyltransferase 2 polymorphism in the ethnic populations of South India. International Journal of Molecular Medicine 11, 125-131.
    42. Anitha, A., and Banerjee, M. (2002). Evaluation of the usefulness of (CA)n Dinucleotide Microsatellite Markers in Paternity Analysis. Problems in Forensic Science 49, 74-79
    43. Anitha A. and Moinak Banerjee. (2001). A novel point mutation in NAT2 gene. Mutation data. Human Genetics Online, Acc. number: H971905
    44. Shankaranarayanan, P., Banerjee, M., Kacker, R.K., Aggarwal, R.K., and Singh, L. (1997). Genetic variation in Asiatic lions and Indian tigers. Electrophoresis 18, 1693-1700.
    45. Banerjee, M., Dinda, A.K., Sinha, S., Sarkar, C., and Mathur, M. (1996). c‐myc oncogene expression and cell proliferation in mixed oligo‐astrocytoma. International journal of cancer 65, 730-733.
    46. Chattopadhyay, P., Banerjee, M., Sarkar, C., Mathur, M., Mohapatra, A.K., and Sinha, S. (1995). Infrequent alteration of the c-myc gene in human glial tumours associated with increased numbers of c-myc positive cells. Oncogene 11, 2711-2714.

    Conference Proceeding in Journal (2004 onwards)

    1. Priya, Krishna, Sasikala, Kesavarao, Banerjee, Moinak, Sreenivas, Lakshmi, Sathyan, Sanish, & Nil, Rajesh. (2015). ASSOCIATION OF IL-1 beta Polymorphisms with Rheumatoid Arthritis is Independent on autoantibody status in South Indian population. Tissue Antigens 85 (5), 394.
    2. Srinivas, L., Neetha, N., Nair, C., Allencherry, P. M. & Banerjee, M. (2014). Association of pro-inflammatory cytokine gene polymorphisms with schizophrenia in South Indian population. Molecular Cytogenetics, 7, P41.
    3. Sebastian M, Davis P, Ramdas P, Banerjee M (2014) A novel mutation in 3’UTR of GJB2 gene in autosomal recessive nonsyndromic sensorineural hearing loss in South Indian population. Molecular Cytogenetics 7: P113
    4. Priya EK, Banerjee M, Rajesh S, Sasikala K (2014) IL 10 gene-1082 G/A shows an associatoin with rheumatoid arthritis patients of South Indian Population. Molecular Cytogenetics 7: P114.
    5. Nair FK, Suresh P, Banerjee M (2014) Genetic variation of ITGB3 is associated with Autism Spectrum Disorders (ASD) in South Indian children. Molecular Cytogenetics 7: P109.
    6. Alex AM, Suresh P, Banerjee M (2014) Association of clock gene variants with Autism Spectrum Disorder in South Indian population. Molecular Cytogenetics 7: P117. 
    7. Balan, S., Sumitha, P., Bharadwaj, T., Lekshmi, S., Sathyan, S., Radhakrishnan, K., and Banerjee, M. (2012). Role of ABCB1 Variants on Postoperative Seizure Recurrence in Patients with AED-Resistant Temporal Lobe Epilepsy. Neurology 78. P05.079
    8. Sathyan, S., Balan, S., Koshy, L, Easwer  HV,  Premkumar S, Alapatt J P, Nair S, Bhattacharya RN , Banerjee M. (2011). The role of Versican and collagen type I alpha2polymorphisms in intracranial aneurysms in a south Indian population. HUGO Journal 5, P127. (Conference proceeding in Journal; Human Genome Organisation-Human Genome Meeting 2011)
    9. Balan, S., Sumitha, P., Bharadwaj, T., Lekshmi, S., Sathyan, S., Radhakrishnan, K., and Banerjee, M. (2011). An inquiry into the role of ABCB1 genetic variants in predisposition to epilepsy and pharmaco resistance. HUGO Journal 5, P83. 
    1. Das, A., Mathew, A., Vijayan, N., Radhakrishnan, K., and Banerjee, M. (2009). A Novel Association of ATP-Binding Cassette Family Gene (ABCB1) among South Indian Patients with Epilepsy. Neurology 72, A7. 
    2. Neetha N V,  Linda Koshy Vaidyan, Chandrasekhar N, Mathew Anila, Chandrashekharan Nair, Allencherry Priya, Moinak Banerjee. (2008) Association studies of neurotransmitter receptor and transporter genes in the theranostics of schizophrenia in a South Indian population. Genomic Med; 2:389–400. 
    3. Vijayan, N., L. Srinivas, L. V. Koshy, C. Natarajan, P. M. Allencherry, C. M. Nair, and M. Banerjee. (2008) “274–Understanding treatment response and association of genotype phenotype correlates in schizophrenia from a population genetics viewpoint.” Schizophrenia Research 98: 146-146.
    4. Anna Alkelai, James Crowley , Tania Das Banerjee, Sophia Docherty, Elizabeth Hare, Michael J Galsworthy, Deepak Grover, Dylan Grubb, Robert Karlsson, Jonathan Mill, Srigan Sen,  Marlon P. Quinones, Eric Vallender, RanjanaVerma, Neetha.N.Vijayan, Sandra Villafuerte, Aristotle N. Voineskos, Heather Volk, Lan Yu, Petra Zimmerman, Coordinated by: Lynn E. DeLisi. (2008) The XVth World Congress of Psychiatric Genetics, October 7-11, 2007; Rapporteur summaries of oral presentations; American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 2, 233-277.
    5. Neetha N V, Sujatha Bhaskar, Linda Koshy Vaidyan, Chandrasekhar N, Chandrashekharan Nair, Moinak Banerjee. (2005). Association of dopamine receptor polymorphisms in schizophrenia. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 131B, 1, 110.
    6. Neetha, N. V., C. Nair, and M. Banjeree. (2004) “Association of SER311CYS DRD2 polymorphism in patients with schizophrenia from South India. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, vol. 130B, 1, 144.
    1. AY310165 Homo sapiens truncated proliferating cell nuclear antigen (PCNA) gene, complete cds.
    2. AY310164 Homo sapiens PCNA gene, exon 1 and partial cds.
    3. AY310163 Homo sapiens PCNA gene, exon 1 and partial cds.
    4. AY310162 Homo sapiens PCNA gene, exon 1 and partial cds.
    5. Y490254 Homo sapiens P-glycoprotein (MDR1) gene, partial cds.
    6. NM_000015 Homo sapiens N-acetyltransferase 2 (arylamine N-acetyltransferase)
    7. AY847950 Cytochrome b gene, partial sequence; mitochondrial of H. puera
    8. AY847951 NADH dehydrogenase subunit-4(ND4) gene, partial sequence; mitochondrial of H. puera C.
    9. AY847952 Cytochrome b gene, partial sequence; mitochondrial of H. puera C. (Coimbatore)
    10. AY847953 Cytochrome oxidase subunit I (COI) gene, partial sequence; mitochondrial of H. puera C.
    11. AY847954 NADH dehydrogenase subunit 1 (ND1) gene, partial sequence; mitochondrial of H. puera C.
    12. AY571148 Cytochrome oxidase I subunit of H. puera C.
    13. AY572232 16S rRNA gene of H. puera C.
    14. AY572235 Cytochrome oxidase gene of H. puera C.
    15. AY575214 12SrRNA gene of H. puera C.
    16. AY572233 28S ribosomal RNA gene of H. puera C.
    17. AY572234 Beta-tubulin intron gene of H. puera C.
    18. AY572236 18s ribosomal RNA gene of H. puera C.
    19. AY572237 Elongation factor I alpha introns of H. puera C.
    20. AY572238 Wingless gene of H. puera C.
    21. AY575215 Elongation factor I alpha gene of H. puera C.
    22. AY847957 Tabanus atratus calo protein-like mRNA, partial cds
    23. AY847955 Moricin I mRNA, partial cds of H. puera C.
    24. AY847956 Moricin II mRNA, partial cds of H. puera C.
    1. Developed Allele Typer a Windows based Allele typing software used for mutation studies.
    2. Developed Genome Profile Analysis (GPA) a windows based software used for mutation analysis on genes of Pharmacogenomic and Immunogenetic interests.
    3. Developed GENOPACK a Linux based software for Allele sequence matching, Sequence Alignment, Complementary and reverse complementary strand generation, Protein translation, Position Matching, Motif matching, Restriction Mapping, Consensus sequence generation, Searching for open reading frames and the corresponding patterns and supports Format conversion.
    4. Developed software, Psychiatric Patient Management System (PPMS) is a PHP PERL based patient data management software based on DSM IV criteria. All the commonly used psychiatric rating scales and side effects rating scales are integrated into the software. It automatically scores the patients positive, negative, cognitive and overall symptoms profile at initial presentation and subsequent followups. It is useful to clinicians, researchers, public health professionals and health inspectors.
  • Team


    Sarada Lekshmi K R, PhD Student

    Dissecting the role of Epigenetics in the genetics of schizophrenia

    Seven percent of Indians, or around seven crore people suffer from mental disorders in one or the other form. Schizophrenia is a biopsychosocial disorder affecting about 1% of world population. The non Mendelian pattern of familial transmission and the lack of disease specific neuropathological features or biomarkers categorise this disease under complex disorders. Attempts to find risk factors for the disorder using epidemiological methods have shown that schizophrenia is highly heritable and path analyses predict that the disorder is caused by several genes in combination with non genetic factors. Several genetic association studies have been conducted worldwide to identify the genetic susceptibility to the disease. However no single gene or genetic variant has been established as bonafide schizophrenia susceptibility gene. Recent thinking suggests that the origin of this disease may not lie strictly in DNA sequence variation rather; these may be coupled with epigenetic dysfunctions as the key etiopathogenic factors. Epigenetic modifications like DNA methylation, histone modifications lead to gene silencing or hyper activation, which collectively contribute to the symptoms observed in patients. Phenotypic diversity based on presentation of symptoms has been observed among schizophrenic patients from different ethno-geographic regions. We aim at dissecting the role of epigenetic modifications, particularly DNA methylation in the etiopathology of schizophrenia in South Indian population. We also try to look into variations at DNA level that influences the epigenetic modifications.

    sarada
    sarada

    Sarada Lekshmi K R, PhD Student

    Dissecting the role of Epigenetics in the genetics of schizophrenia

    Seven percent of Indians, or around seven crore people suffer from mental disorders in one or the other form. Schizophrenia is a biopsychosocial disorder affecting about 1% of world population. The non Mendelian pattern of familial transmission and the lack of disease specific neuropathological features or biomarkers categorise this disease under complex disorders. Attempts to find risk factors for the disorder using epidemiological methods have shown that schizophrenia is highly heritable and path analyses predict that the disorder is caused by several genes in combination with non genetic factors. Several genetic association studies have been conducted worldwide to identify the genetic susceptibility to the disease. However no single gene or genetic variant has been established as bonafide schizophrenia susceptibility gene. Recent thinking suggests that the origin of this disease may not lie strictly in DNA sequence variation rather; these may be coupled with epigenetic dysfunctions as the key etiopathogenic factors. Epigenetic modifications like DNA methylation, histone modifications lead to gene silencing or hyper activation, which collectively contribute to the symptoms observed in patients. Phenotypic diversity based on presentation of symptoms has been observed among schizophrenic patients from different ethno-geographic regions. We aim at dissecting the role of epigenetic modifications, particularly DNA methylation in the etiopathology of schizophrenia in South Indian population. We also try to look into variations at DNA level that influences the epigenetic modifications.

    Sanish Sathyan, PhD Student

    Delineation of genes associated with remodeling of extracellular matrix and endothelial dysfunction in intracranial aneurysm

    Remodeling of Extracellular matrix(ECM) and endothelial dysfunction play a major role in pathogenesis of cerebral aneurysm. Structural integrity of the vessel wall relies on balance between synthesis and degradation of ECM proteins. Endothelial dysfunction is characterized by an imbalance of endothelium derived relaxing and contracting factor. My area of research involves analyzing the variants in genes involved for having association with intracranial aneurysm by case –control study, approach.

    sanish
    sanish

    Sanish Sathyan, PhD Student

    Delineation of genes associated with remodeling of extracellular matrix and endothelial dysfunction in intracranial aneurysm

    Remodeling of Extracellular matrix(ECM) and endothelial dysfunction play a major role in pathogenesis of cerebral aneurysm. Structural integrity of the vessel wall relies on balance between synthesis and degradation of ECM proteins. Endothelial dysfunction is characterized by an imbalance of endothelium derived relaxing and contracting factor. My area of research involves analyzing the variants in genes involved for having association with intracranial aneurysm by case –control study, approach.

    Swathy.B, PhD Student

    Evaluating pharmaco-epigenomic response of antipsychotic drugs

    Antipsychotic drugs are the most common form of treatment for Schizophrenia and related mental disorders. The pharmacokinetics and pharmacodynamics of antipsychotic drugs are known to differ among individuals and are influenced by factors like age, gender, ethnicity, genetics and nutritional status.Pharmacoepigenetics potentially offers another level of explanation for interindividual variations in drug response that cannot be accounted for on the basis of genetic polymorphism. The objective of my study is to understand the pharmacoepigenetic aspects of antipsychotic drugs. Identification of epigenetic modifications occurring in genes associated with antipsychotic drug response and side effects will help us to understand the influence of epigenetics in antipsychotic drug response and elucidate the mechanism of antipsychotic drug induced side effects.

    swathy
    swathy

    Swathy.B, PhD Student

    Evaluating pharmaco-epigenomic response of antipsychotic drugs

    Antipsychotic drugs are the most common form of treatment for Schizophrenia and related mental disorders. The pharmacokinetics and pharmacodynamics of antipsychotic drugs are known to differ among individuals and are influenced by factors like age, gender, ethnicity, genetics and nutritional status.Pharmacoepigenetics potentially offers another level of explanation for interindividual variations in drug response that cannot be accounted for on the basis of genetic polymorphism. The objective of my study is to understand the pharmacoepigenetic aspects of antipsychotic drugs. Identification of epigenetic modifications occurring in genes associated with antipsychotic drug response and side effects will help us to understand the influence of epigenetics in antipsychotic drug response and elucidate the mechanism of antipsychotic drug induced side effects.

    Ann Mary Alex, PhD Student

    Genetic and epigenetic control of Monoamine biosynthetic pathway in Autism phenotypes

    Autism is a complex disorder with a high degree of heritability and significant phenotypic and genotypic heterogeneity. It appears in the first 3 years of life and affects the brain’s normal development of social and communication skills. The prevalence of autism is estimated at 0.1–0.3%. The observable phenotype associated with circadian rhythm is, disturbances in sleep, while observable phenotype for deficits in memory, is associated with sensory dysfunction. The aim of my study is to understand the genes that influence these two major underlying phenotypes independently and how they influence the genetic network, in the development of autism.

    ann
    ann

    Ann Mary Alex, PhD Student

    Genetic and epigenetic control of Monoamine biosynthetic pathway in Autism phenotypes

    Autism is a complex disorder with a high degree of heritability and significant phenotypic and genotypic heterogeneity. It appears in the first 3 years of life and affects the brain’s normal development of social and communication skills. The prevalence of autism is estimated at 0.1–0.3%. The observable phenotype associated with circadian rhythm is, disturbances in sleep, while observable phenotype for deficits in memory, is associated with sensory dysfunction. The aim of my study is to understand the genes that influence these two major underlying phenotypes independently and how they influence the genetic network, in the development of autism.

    Shafeeque C M, PhD Student

    Elucidating Genetics of Methylation Map in Intracranial Aneurysm

    Cerebral aneurysm is a complex disorder having both genetic and environmental components involved. 85% of aneurysms can cause sub arachnoid haemorrhage which in leads to death in 60% of cases. I am interested in dissecting the epigenetic modulation in the pathophysiology of the disease. My study focus on methylation pathway genes which responds to environmental cues and regulate gene expression. This study will provide better understanding of the interplay between the genes associated with aneurysm and their epigenetic modulation in background of various environmental risk factor.

    shafeeque webpage
    shafeeque webpage

    Shafeeque C M, PhD Student

    Elucidating Genetics of Methylation Map in Intracranial Aneurysm

    Cerebral aneurysm is a complex disorder having both genetic and environmental components involved. 85% of aneurysms can cause sub arachnoid haemorrhage which in leads to death in 60% of cases. I am interested in dissecting the epigenetic modulation in the pathophysiology of the disease. My study focus on methylation pathway genes which responds to environmental cues and regulate gene expression. This study will provide better understanding of the interplay between the genes associated with aneurysm and their epigenetic modulation in background of various environmental risk factor.

    Sindura K P, PhD Student

    Sindura K P
    Sindura K P

    Sindura K P, PhD Student

  • Alumni


    Project Scientist at HMG

    Sujatha Baskaran, PhD

    Present position:

    • Consultant, Molecular Diagnostic Laboratory, Kovai Medical Center and Hospital, India
    • Scientist, Dept. of Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala

    Sujatha Baskaran, PhD

    Present position:

    • Consultant, Molecular Diagnostic Laboratory, Kovai Medical Center and Hospital, India
    • Scientist, Dept. of Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala

    Post-Doctoral Fellows

    Sreekumar R, PhD

    Present position:

    • Research Specialist, Stowers Institute for Medical Research, Missouri, US
    • Department of Neurobiology, Weizmann Institute of Science, Israel.

    Sreekumar R, PhD

    Present position:

    • Research Specialist, Stowers Institute for Medical Research, Missouri, US
    • Department of Neurobiology, Weizmann Institute of Science, Israel.

    Dr. Arani Chatterjee, M.B.B.S, M.Phil., PGCPM

    Present position:

    • Senior Vice President, Clinical Research, Biological E limited, Hyderabad, India
    • Senior Vice President, Clinical Research, Panacea Biotech Ltd, New Delhi, India
    • Dr. Reddy's Laboratories, Principal Physician, Clinical Research

    Dr. Arani Chatterjee, M.B.B.S, M.Phil., PGCPM

    Present position:

    • Senior Vice President, Clinical Research, Biological E limited, Hyderabad, India
    • Senior Vice President, Clinical Research, Panacea Biotech Ltd, New Delhi, India
    • Dr. Reddy's Laboratories, Principal Physician, Clinical Research

    Krishnan M, PhD

    Present position:

    • Postdoctoral Researcher, Department of Microbiology and Immunology/Center for Airway Inflammation Research, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • Postdoctoral Researcher, The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University, Palo Alto, California.

    Krishnan M, PhD

    Present position:

    • Postdoctoral Researcher, Department of Microbiology and Immunology/Center for Airway Inflammation Research, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • Postdoctoral Researcher, The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University, Palo Alto, California.

    Saadi Abdul Wahab, PhD

    Present position:

    • Associate Professor, Department of Biotechnology, KMC Life Sciences, Manipal.

    Saadi Abdul Wahab, PhD

    Present position:

    • Associate Professor, Department of Biotechnology, KMC Life Sciences, Manipal.

    Dr. Mini, MD, DM

    Present position:

    • Assistant Professor, Department of Pediatric Neurology, Medical College, Trivandrum, India.

    Dr. Mini, MD, DM

    Present position:

    • Assistant Professor, Department of Pediatric Neurology, Medical College, Trivandrum, India.

    Graduate Students at HMG

    Anitha A Pillai, PhD

    Year: 1996 - 2003

    Thesis: Molecular signatures of Tribal Populations in Kerala based on DNA Finger printing

    Present position:

    • Associate Professor, Genetics Laboratory, Institute for Communicative and Cognitive Neurosciences (ICCONS), Kerala, India
    • Assistant Professor, Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan

    Anitha A Pillai, PhD

    Year: 1996 - 2003

    Thesis: Molecular signatures of Tribal Populations in Kerala based on DNA Finger printing

    Present position:

    • Associate Professor, Genetics Laboratory, Institute for Communicative and Cognitive Neurosciences (ICCONS), Kerala, India
    • Assistant Professor, Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan

    Rasmi Thomas, PhD

    Year: 2000-2005

    Thesis: Immunogenetic Profiling and Disease Association of HLA Class India 1 Genes in different population of Kerala

    Present position:

    • Chief, Host Genetics Section, US Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, MD
    • Post-Doctoral Researcher, Frederick National Laboratory at the NIH institute in Frederick, MD.
    • Associate Editor

    Rasmi Thomas, PhD

    Year: 2000-2005

    Thesis: Immunogenetic Profiling and Disease Association of HLA Class India 1 Genes in different population of Kerala

    Present position:

    • Chief, Host Genetics Section, US Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, MD
    • Post-Doctoral Researcher, Frederick National Laboratory at the NIH institute in Frederick, MD.
    • Associate Editor

    Chandrasekhar Natarajan, PhD

    Year: 2001 - 2008

    Thesis: Population dynamics, molecular phylogeny and characterization of antimicrobial peptides of teak defoliator (Hyblae puera cramer)

    Present position:

    • Senior Research Associate, University of Nebraska-Lincoln
    • Postdoctoral Research Associate, University of Nebraska-Lincoln

    Chandrasekhar Natarajan, PhD

    Year: 2001 - 2008

    Thesis: Population dynamics, molecular phylogeny and characterization of antimicrobial peptides of teak defoliator (Hyblae puera cramer)

    Present position:

    • Senior Research Associate, University of Nebraska-Lincoln
    • Postdoctoral Research Associate, University of Nebraska-Lincoln

    Neetha N V, PhD

    Year: 2003 - 2009

    Thesis: Pharmacogenetic Profiling for Theranostic Evaluation of Schizophrenia in a South Indian Population

    Present position:

    • Post-Doctoral Research Associate at (Miller Lab) University of Nebraska, Lincoln
    • Post-Doctoral Fellow at (Brisson lab) University of Nebraska, Lincoln

    Neetha N V, PhD

    Year: 2003 - 2009

    Thesis: Pharmacogenetic Profiling for Theranostic Evaluation of Schizophrenia in a South Indian Population

    Present position:

    • Post-Doctoral Research Associate at (Miller Lab) University of Nebraska, Lincoln
    • Post-Doctoral Fellow at (Brisson lab) University of Nebraska, Lincoln

    Linda Koshy Vaidyan, PhD

    Year: 2003 - 2009

    Thesis: Genetic Dissection of Intracranial Aneurysms in South Indian Population

    Present position:

    • Research Associate, Inter-University Centre for Genomics and Gene Technology, Trivandrum, Kerala, India
    • Post-Doctoral Research Fellow, Yamaguchi University Graduate School of Medicine, Japan

    Linda Koshy Vaidyan, PhD

    Year: 2003 - 2009

    Thesis: Genetic Dissection of Intracranial Aneurysms in South Indian Population

    Present position:

    • Research Associate, Inter-University Centre for Genomics and Gene Technology, Trivandrum, Kerala, India
    • Post-Doctoral Research Fellow, Yamaguchi University Graduate School of Medicine, Japan

    Lekshmy Srinivas, PhD

    Year: 2005 - 2013

    Thesis: Genetic Predisposition to Schizophrenia in South Indian Population: An Immunogenetic Perspective

    Present position:

    • Research Associate, Inter-University Centre for Genomics and Gene Technology, Trivandrum, Kerala, India
    • Scientist at Xcelris Genomics, Ahmedabad, Gujarat, India

    Lekshmy Srinivas, PhD

    Year: 2005 - 2013

    Thesis: Genetic Predisposition to Schizophrenia in South Indian Population: An Immunogenetic Perspective

    Present position:

    • Research Associate, Inter-University Centre for Genomics and Gene Technology, Trivandrum, Kerala, India
    • Scientist at Xcelris Genomics, Ahmedabad, Gujarat, India

    Graduate Students at HMG (Collaborative programs)

    Manna Jose, PhD

    Year: 2006 - 2010

    Thesis: Pharmacogenetic study to evaluate the teratogenic effects of anti-epileptic drugs

    Present position:

    • Research Associate, SCTIMST
    • Lecturer, University College, Trivandrum

    Manna Jose, PhD

    Year: 2006 - 2010

    Thesis: Pharmacogenetic study to evaluate the teratogenic effects of anti-epileptic drugs

    Present position:

    • Research Associate, SCTIMST
    • Lecturer, University College, Trivandrum

    Shabeesh Balan, PhD

    Year: 2008-2012

    Thesis: Pharmacogenetic evaluation of drug resistant epilepsy patients in a south Indian population

    Present position:

    • Research Scientist , ​Laboratory for Molecular Psychiatry, RIKEN- Brain Science Institute, Japan
    • Researcher, ​Laboratory for Molecular Psychiatry, RIKEN- Brain Science Institute, Japan

    Shabeesh Balan, PhD

    Year: 2008-2012

    Thesis: Pharmacogenetic evaluation of drug resistant epilepsy patients in a south Indian population

    Present position:

    • Research Scientist , ​Laboratory for Molecular Psychiatry, RIKEN- Brain Science Institute, Japan
    • Researcher, ​Laboratory for Molecular Psychiatry, RIKEN- Brain Science Institute, Japan

    Project Fellows

    Anila Mathew, PhD

    Year: 2007-2009

    Project: Genetics of AED teratogenicity

    Present position:

    • Post-Doctoral Researcher, Bio-Nano Electronics Research Centre, Toyo University, Japan.
    • Post-Doctoral Research Fellow, Nihon University, Japan.
    • Graduate Student, Bio-Nano Electronics Research Centre, Toyo University, Saitama, Japan.

    Anila Mathew, PhD

    Year: 2007-2009

    Project: Genetics of AED teratogenicity

    Present position:

    • Post-Doctoral Researcher, Bio-Nano Electronics Research Centre, Toyo University, Japan.
    • Post-Doctoral Research Fellow, Nihon University, Japan.
    • Graduate Student, Bio-Nano Electronics Research Centre, Toyo University, Saitama, Japan.

    Pravi Vidyadharan

    Year: 2007-2008

    Project: Genetics of Oral submucous fibrosis

    Present position:

    • Senior Research Fellow at Central Tuber Crops Research Institute, Thiruvananthapuram

    Pravi Vidyadharan

    Year: 2007-2008

    Project: Genetics of Oral submucous fibrosis

    Present position:

    • Senior Research Fellow at Central Tuber Crops Research Institute, Thiruvananthapuram

    Asha Nair

    Year: 2007-2008

    Project: Schizophrenia epigenetics

    Present position:

    • Graduate Student, School of Integrative Biology, University of Queensland. Brisbane. Australia.

    Asha Nair

    Year: 2007-2008

    Project: Schizophrenia epigenetics

    Present position:

    • Graduate Student, School of Integrative Biology, University of Queensland. Brisbane. Australia.

    Sumitha P.B

    Year: 2008 – 2009

    Project: Epilepsy pharmacogenetics

    Present position:

    • Graduate Student, The Centre for Stem Cell Research, Christian Medical College, Vellore, India

    Sumitha P.B

    Year: 2008 – 2009

    Project: Epilepsy pharmacogenetics

    Present position:

    • Graduate Student, The Centre for Stem Cell Research, Christian Medical College, Vellore, India

    Bazil Paul, PhD

    Year: 2010

    Project: Schizophrenia epigenetics

    Present position:

    • Post-doctoral research fellow,  Baylor College of Medicine, Houston, United States
    • Graduate Student, Department of Psychiatry, The University of Hong Kong, Hong Kong

    Bazil Paul, PhD

    Year: 2010

    Project: Schizophrenia epigenetics

    Present position:

    • Post-doctoral research fellow,  Baylor College of Medicine, Houston, United States
    • Graduate Student, Department of Psychiatry, The University of Hong Kong, Hong Kong

    Tashi Bharadwaj

    Year: 2009 - 2011

    Project: Genetics of AED teratogenicity

    Present position:

    • Graduate Student, Department of Genomic Science, Central University of Kerala, India

    Tashi Bharadwaj

    Year: 2009 - 2011

    Project: Genetics of AED teratogenicity

    Present position:

    • Graduate Student, Department of Genomic Science, Central University of Kerala, India

    Anaswara Ashok

    Year: 2012-2013

    Project: Genetics of hearing loss

    Presently settled in Norway

    Anaswara Ashok

    Year: 2012-2013

    Project: Genetics of hearing loss

    Presently settled in Norway