Molecular Screening Facility

This resource facility is equipped with various resources for screening small molecules for different molecular properties.

Services

SL No: Service Service Charges
RGCB Users Clients from Academic Institutions Clients from the Industry or Overseas
I

Quantitative dose-response analysis of growth inhibitory activity or cytotoxicity: This will be the preliminary screening where compounds will be tested for their cytotoxicity and optimum doses for further studies will be evaluated.

2000 3000 5500 or ($90)
Four concentrations of compound in triplicate/time point/cell/sample
II

Screening for HIF inhibitors: The discovery of hypoxia inducible factors (HIFs), which mediate transcriptional responses to changes in oxygen levels will allow this signalling be used for drug screening compounds that inhibit Hypoxic response in cancer. We have developed stable cells with reporter vectors with HRE-Luc or HRE-mCherry-Luc that will allow identification of inhibitors by Luciferase assay.

2000 3000 5500 or ($90)
Four concentrations of compound in triplicate/time point/cell/sample
III

Gene expression studies: We have two platforms available. Step One plus (Invitrogen 96-well format) and ABI 7900HT (96 and 384 well format).

1000 3000 5500 or ($90)
One gene and housekeeping gene
IV

Next generation sequencing: We have equipped with Ion Torrent and PGM platform from Invitrogen and capable of doing various assays including exome sequencing, transcriptome sequencing, microbiome analysis etc. We have in house computation facility for analysis.

For pricing contact us with your specific requirement.
V

Microarray analysis: We have equipped with Affymetrix platform and help you to address your research needs.

For pricing contact us with your specific requirement.

Contact

Rajiv Gandhi Centre for Biotechnology (RGCB),
Thycaud Post, Poojappura,
Thiruvananthapuram - 695 014, Kerala, India
+91-471-2529400 | 2347975 | 2348753
+91-471-2348096
webmaster@rgcb.res.in