Ratheeshkumar T, PhD (SERB - National Post-doctoral Fellow)
Pancreatic ductal adenocarcinoma (PDAC) is the most common among pancreatic cancers and is one of the greatest challenges in cancer research because of the late detection and lack of proper treatment strategies. Population based studies indicate that breast cancer susceptibility genes BRCA1, BRCA2 mutation and insulin administration are high risk factors in developing PDAC. Never the less the molecular mechanism behind is largely unknown. My preliminary objective is the in vitro evaluation of the molecular mechanism behind the occurrence of PDAC in BRCA1/BRCA2 mutated patients undertaking insulin administration.