Sajitha I S, MVSc
PhD student (in the Faculty Improvement Program, College of Veterinary Sciences)
Multidrug resistance implies the insensitivity of a sub population of cancer cells to cytostatic and cytotoxic actions of various structurally and functionally unrelated chemotherapeutics. Such surviving cells will repopulate the original tumour causing local recurrence and distant metastasis. My work aims to study the kinetics of emergence of drug resistant cells after exposure to chemotherapeutics and its role in tumour recurrence. The study involves development of drug resistant cells from multiple cancer cell lines. The kinetics of tumour initiation in SCID mice is studied using both the parental and drug resistant cells, which will help us to understand the importance of such drug surviving cells in tumour recurrence and relapse.