Neelima Singh, Ph.D, Post-Doctoral Fellow
Heart balances uptake, metabolism and oxidation of fatty acids to maintain ATP production, membrane biosynthesis and lipid signaling. Under pathological conditions such as obesity, type-2-diabetes, and ageing, cardiac uptake and oxidation of fatty acids are compromised that leads to cardiac lipotoxicity. Lipotoxicity is defined as excess accumulation and over-activation of lipid signaling pathways which trigger cellular dysfunction and death. When this process occurs in cardiomyocytes, the consequences lead to cardiac dysfunction and heart failure. The fatty acid metabolites linked with cardiac lipotoxicity include ceramides, diacylglycerol (DAG), long-chain-acyl-CoAs, acylcarnitines, lysophospholipids and triacylglycerols (TAG). However cardiac lipid metabolism and its regulation are still relatively unexplored. We aim to understand the metabolism and regulation of lipids such as TAG, DAG and phosphatidylinositol (PI) under lipotoxic environment.