Jazir Haneef, PhD Student
Molecular effects of flavonoids on Estrogen Receptor (ER) mediated pathways
The steroid hormone estrogen causes its multitude effects through estrogen receptors that mediate the transcription of number of genes involved in reproduction, metabolism, growth and differentiation. It has been widely established that flavonoids, a group of polyphenolic phytochemicals can exert various biological effects including anti-oxidant, anti-carcinogenic, anti-inflammatory and also modulate the function of sex hormones and their receptors. Experimental studies have also revealed that these components regulate the molecules in the cell signaling transduction pathways, including NF-?B, MAPK, p53, AR and ER pathways. In this study I am focusing on finding out flavonoids with potential estrogenic activities, elucidating the molecular mechanisms of action of individual phytoestrogens and its use against hormone dependant cancers giving emphasis to estrogen receptor mediated pathways.