Profile

Research

Publications

Team

Alumni

Sabu Thomas, PhD

Scientist E-II

+91-471-2529521

sabu@rgcb.res.in

Dr. Sabu Thomas
Dr. Sabu Thomas

Sabu Thomas, PhD

Scientist E-II

+91-471-2529521

sabu@rgcb.res.in

  • Profile

    • PhD, Aquatic Biology, Kerala University
    • MSc Zoology, Mahatma Gandhi University
    • 2015: Scientist EII
    • 2009: Scientist EI
    • 2004: Scientist C
    • 2001: Scientist B
    • 1996: Post-doctoral Fellow
    • 1994: Research Assistant
    • WHO Global Task Force Member on Cholera Control (Laboratory Methods)
    • Second Indian Arctic Scientific Expedition Member, MoES, Govt. of India
    • Biography cited in Marquis Who’s Who in the World – Medicine and Healthcare, USA
    • Bill and Melinda Gates Foundation Global Health Award Winner -2009
    • Fellow of International Society of Biotechnology ( FISBT)
    • Scientist Par Excellence Award of Rotary Club
    • Fellow Award in Medical Biotechnology of Society for Applied Biotechnology

    Membership in International Scientific Organizations

    • Global Foodborne Infections Network (GFN) of WHO
    • CHOLDInet -Global Laboratory Network for Cholera and other Diarrhoeal Infections
    • International Society for Infectious Diseases (ISID),USA
    • Freshwater Action Network South Asia (FANSA)

    Membership in National Organizations

    • Biotech Research Society of India
    • Indian Meteorological Association
    • Kerala Academy of Sciences

    Editorial Membership

    • Sub Editor, Indian Journal of Environment and Ecoplanning ( ISSN 0972-1215)
    • Editorial Board Member, Research Journal of Biotechnology( ISSN 0973-6263)

    Academic Membership

    • Doctoral Advisory Committee Member: SASTRA University, Thanjavur & Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum
    • Expert member for the evaluation of Contest Papers in Biotechnology / Health Sciences of Kerala Science Congress
    • Expert for the contest poster presentations in International Conference on Infectious Disease and Nanomedicine-2015at Kathmandu,Nepal

    PhD Thesis Guided

    • Dr. Praveen Kumar P.P, 2011.Molecular Characterization of the Environmental strains of Vibrio cholerae isolated from the aquatic sources in Southern Kerala.
      (Awarded Dr. M R Das Career Award for outgoing PhD students)

    Current PhD students

    • 06

    MD/MDS Thesis Co-guided

    • Dr. Mohammed Hisham P.P, Govt. Medical College, Kozhikode,  2011
    • Dr. Swapana Helen John, Govt. Medical College, Kozhikode,  2012
    • Dr. Pressy Sankar, Govt. Medical College, Trivandrum,  2013
    • Dr. Soumia S, Govt. Medical College, Trivandrum,  2014
    • Dr. Priyanka R Nair, Govt. Medical College, Trivandrum, 2015
    • Dr. Vivek Chand. C U, Govt. Dental College, Trivandrum, 2015
    • Organizing Convenor, International Conference on Regulatory Network Architecture In Bacteria, March 9-11,2012, Jointly organized by SASTRA University, Thanjavur and Rajiv Gandhi Center for Biotechnology
  • Research

    Cholera Research

    researchsabu

    Vibrio cholerae and Vibrio parahaemolyticus are the two important human pathogens in Vibrionaceae family. V. cholerae is responsible for the severe diarrheal disease- cholera while V. parahaemolyticus causes pandemics of gastroenteritis especially in countries where sea-food consumption is high. Indian sub-continent has been the centre point for most of the cholera pandemics. The current ongoing pandemic is caused by the El Tor biotype. But, this biotype is constantly evolving with respect to cholera toxin genes and antibiotic resistance. Nowadays these variants have completely replaced the prototype El Tor strains. The recent devastating cholera outbreak in Haiti was caused by a novel variant of V.cholerae O1 El Tor wave 3 which is hypothesized to have originated from Indian subcontinent. We are presently investigating the ctxB genotype, cholera toxin production level of altered El Tor strains to monitor the severity in the symptoms of the disease, antibiotic susceptibility and the role of plasmids, SXT constin and integrons in conferring multiple drug resistance in V.cholerae strains collected during various outbreaks in the country. We are also interested in studying the prevalence and pathogenic nature of V. parahaemolyticus isolated from environment and sea-food samples. We are employing next generation sequencing to understand the difference in genomic content and pathogenicity between clinical and environmental strains of V.parahaemolyticus as well as between the different hemolysin types of the bacterium.

    Bacterial Biofilm Research

    Biofilms are the ubiquitous and natural phenotype of bacteria. Bacteria that reside within mature biofilms are highly resistant to antibiotics and host immune response due to the complex architecture and composition of the extracellular matrix.Recent studies have shown the key role played by the biofilm mode of life adapted by microbes in the emergence of resistant strains, pathogenicity, host colonization and survival in the natural as well as human niches of vibrio species. So, targeting biofilm formation is considered as a potential anti-virulent strategy to treat infections caused by bacterial pathogens. In this context, the lab is focused on discovering potential anti-biofilm compounds against vibrios employing two strategies:

    • Screening natural sources for anti-biofilm compounds, especially from plants, actinomycetes and phytochemicals.
    • Identification of conserved biofilm inhibiting targets by employing transcriptomic and proteomic approaches. The identified targets could be used in modern computational based drug discovery approaches for accelerating the development of broad spectrum anti-biofilm compounds. Besides, we have also extended research in studying the polymicrobial communities and its biofilm matrix associated components in chronic wounds in clinical settings. It is crucial to understand the diversity and ecology of microbiota in chronic wound biofilms as diabetes and related wound infections are on a rise globally. This study aims in generating antibiofilm based therapy for enhancing the efficacy of antibiotic therapy which in turn will aid the clinicians to improve the treatment procedures avoiding severe amputations and morbidity in the affected patients.

    Probiotics Research

    Probiotics are the health enhancing therapeutics which when administered in adequate amounts confers a health benefit on the host. The rationale for using probiotics in acute infectious diarrhoea is based on the assumption that they act against intestinal pathogens and possible mechanisms include the synthesis of antimicrobial substances, competitive inhibition of pathogen adhesion, modification of toxin and non-toxin receptors and stimulation of non-specific and specific immune responses to pathogens. The primary objective is to come up with a potential probiotic strain which could be used as an alternative or complementary strategy against diarrhea due to cholera. Hence the characterization of a novel probiotic strain with new and desirable properties is appropriate especially in countries like India where cholera is endemic.

    Bioprospecting bacteria isolated from Arctic, the North Pole

    The permanently cold environments on the Earth’s surface have been successfully colonized by a group of extremophilic microorganisms called psychrophiles (cold-loving). Psychrophiles have successfully evolved genotypic and phenotypic features that allow to overcome the negative effects of low temperature. Studying the cold adaptation of these cold adapted bacteria is very essential as it may provide valuable insights for improving the products of biotechnology industries. In this context, our lab is focused on studying the following aspects of psychrophilic bacteria.

    1. Bioprospecting novel bioactive molecules of medical importance
    2. Understanding the Quorum Sensing mediated biofilm regulation in psychrophiles.
    3. Study the mechanism of cold adaptation via genomic and proteomic approach.
    4. We have also noticed multi-drug resistant strains in Artic bacterial collection and studies are extended to understand the molecular mechanism and mode of transmission of antibiotic resistance.

    MICROBE-HUNTING EXPEDITION TO THE NORTH POLE

    Dr. Sabu Thomas and Mr. Wilson Peter Abraham have been selected for the Indian Arctic Expedition – 2009-10, for a study on the genetic diversity of cold-adapted bacteria with special reference to marine Vibrios isolated from Arctic realms/fjords. The first phase of the summer time studies is scheduled to commence at the Indian Arctic Research Station, Ny-Alesund, on the 18th of June and will last till the 17th of July, 2009.

    Read Media News here

    Sl.No Title of Project Funding Agency Duration No. of Publications
    1 Molecular characterization of the pesticide/heavy metal compounds degrading microorganisms isolated from the Kuttanad and other waterbodies of Kerala DBT, Govt. of India 2001-03 6
    2 Detection and molecular characterization of microbial population from different polluted zones caused by coir retting DBT 2002-04 3
    3 Biodegradation of phenolic compounds by activated sludge process and development of useful microbes for coir extraction and Tannase production from coconut husk retting areas DBT 2005-08 2
    4 Molecular monitoring of Vibrio cholerae in the epidemic prone aquatic environment of Kottayam and Alappuzha districts in Kerala KSCSTE, Govt. of Kerala 2007- 10 10
    5 Bioprospecting bacteria isolated from the Arctic Intramural support 2010-14 8
    6 Genetic manipulation of "COIRRET"Cholera and Traveller for application on coir for quality improvement Central Coir Board, Govt. of India 2011-14 2
    7 Novel biofilm inhibitors from selected plants against Vibrio cholerae: isolation and characterization DRDO, Govt. of India 2012-14 3
    8 Health promoting properties of potential probiotic strains isolated from infant gut microflora ICMR, Govt. of India 2015- 17
    9 Development of probiotic therapy using indigenous bacterial flora of human origin against Cholera and Traveller's disease LSRB, Govt. of India 2015 (submitted for approval)
    10 Analysis of polymicrobial biofilms in chronic wound infections and development of anti-biofilm therapeutic to promote wound healing DBT, Govt. of India 2016-2019 (Approved)
  • Publications

    Research Papers: 63, Book Chapters: 09, Conference presentations: 24, Invited lecture: 25

    Publications

    1. Divya MP, Chowdhury G, Pazhani GP, Ramamurthy T, Sabu Thomas. 2016. Draft genome sequence of an environmental trh+Vibrio parahaemolyticus K23 strain isolated from Kerala, India. Genome Announc 4(2):e00282-16. doi:10.1128/genomeA.00282-16.
    2. Karthika S., Reshma M. J., Wilson P. A., Anita Das R., Sarma U. S., Harikrishnan K & Sabu Thomas. 2016. Characterization and Evaluation of Phenol Degrading Bacillus Spp. for Enhancing the Softness of Coir Fiber. Journal of Natural Fibers, 13:3, 253-260.
    3. Dharmaprakash A, Reghunathan D, Krishnankutty SC, Prasannakumar M, Thomas S. 2016. Insights into the genome sequences of two N-acyl homoserine lactone molecule-producing Pseudomonas spp. strains isolated from the Arctic. Genome Announc 4(4):e00767-16. doi:10.1128/genomeA.00767-16.
    4. Wilson Peter A and Sabu Thomas. 2015. Draft Genome Sequence of Pseudomonas psychrophila MTCC 12324 Isolated from the Arctic at 79°North. Genome Announcement. 3(3):e00578-15
    5. Divya M P, Deepa Mathew P, Jyothi R, Ramani Bai and Sabu Thomas. 2015. Mutations in Gyr A and Par C genes of Shigella flexneri 2a determining the fluoroquinolone resistance. Indian Journal of Medical Research. 141(6):37-39
    6. Dharmaprakash A, Thandavarayan R, Joseph I, Thomas S. 2015. Development of broad-spectrum antibiofilm drugs: strategies and challenges. Future Microbiology. 10(6):1035-48.
    7. Karthika Suryalatha, Joby John & Sabu Thomas. 2015. Wohlfahrtiimonas chitiniclastica associatedosteomyelitis: A rare case report. Future Microbiology. 10(7): 1107-1109.
    8. Wilson Peter A and Sabu Thomas. 2015. Cold Adaptations of Bacteria from Arctic. Proceedings of SVASH, 119-122
    9. Shuvankar Ballav, Savita Kerkar, Sabu Thomas and Nimmy Augustine. 2015. Halophilic and halotolerant actinomycetes from a marine saltern of Goa, India producing anti-bacterial metabolites. Journal of Bioscience and Bioengineering. 119(3):323-30.
    10. Divya M P, Sivakumar K C, Sarada Devi K L, Remadevi S and Sabu Thomas. 2014. Novel multiple mutations in topoisomerase gene of Haitian variant Vibrio cholerae O1, Antimicrobial Agents and Chemotherapy. 58(8):4982-3.
    11. Dharmaprakash Akhilandeswarre, Mutt Eshita, Jaleel Abdul, Ramanathan Sowdhamini  and Sabu Thomas. 2014. Proteome profile of pandemic Vibrio parahaemolyticus SC192 strain during planktonic and biofilm condition. Biofouling: The Journal of Bioadhesion and Biofilm Research. 30(6), 729-739.
    12. G Vinoj, B Vaseehran, Sabu Thomas, A.J. Spiers and S. Shanthi, 2014. Quorum Quenching activity of the AHL lactonase from Bacillus licheniformis DAHB1 inhibits Vibrio biofilm formation in vitro and reduces shrimp intestinal colonization and mortality, Marine Biotechnology. 16(6):707-15.
    13. Karthika S and Sabu Thomas. 2013. Biotechnology and Environmental Conservation – A Perspective. Journal of Basic and Applied Biology. 8(1):26-31.
    14. Wilson Peter A and Sabu Thomas. 2013. Diversity and Bioprospecting potential of bacteria isolated from the Arctic: A preliminary study. Mapana Journal of Science. 12(4):19-28.
    15. Sudha A, Nimmy Augustine and Sabu Thomas, 2013. Emergence of multi-drug resistant bacteria in the Arctic, 790N. J. Cell and Life Sciences, 1(1):1-5
    16. Diana E Waturangi, IgnasiusJoanito, Yogiara Yogi and Sabu Thomas, 2012. Use of REP- and ERIC-PCR to reveal genetic heterogeneity of Vibrio cholerae from edible ice in Jakarta, Indonesia, Gut Pathogens,4:2
    17. B.B. Lahiri, M.P. Divya, S. Bagavathiappan, Sabu Thomas and John Philip, 2012. Detection of Pathogenic Gram Negative Bacteria using Infrared Thermography, Infrared Physics & Technology, 55:485-490.
    18. Vinothkannan Ravichandiran,Karthi S,Sabu Thomas and Adline Princy, 2012. Structure-based virtual screening for plant-derived SdiA-selective ligands as potential antivirulent agents against uropathogenic Escherichia coli. Eur J Med Chem, 48:200-5.
    19. Praveen Kumar and Sabu Thomas, 2011. Presence of qnrVC3 gene cassette in SXT and class 1 integrons of Vibrio cholerae, International Journal of Antimicrobial Agents, 37(3):280-1.
    20. Praveen Kumar and Sabu Thomas, 2011. Classical ctxB gene in Vibrio cholerae O1 and O56 serogroups from Kerala, South India. J. Medical Microbiology, 60(4):559-60.
    21. Nimmy Augustine, A.K. Goel, K.C. Sivakumar, R. Ajay Kumar, Sabu Thomas, 2013. Resveratrol – A potential inhibitor of biofilm formation in Vibrio cholerae, Phytomedicine, 21(3)286-289.
    22. Nimmy Augustine, Wilson Peter, Savita Kerkar and SabuThomas, 2012. Arctic Actinomycetes as potential inhibitors of Vibrio cholerae biofilm. Current Microbiology 64(4):338-42.
    23. Praveen Kumar, Anuja Thulaseedharan, Gautam Chowdhury, Thandavarayan Ramamurthy and Sabu Thomas, 2011. Characterization of novel alleles of toxin co-regulated pilusA gene (tcpA) from environmental isolates of Vibrio cholerae, Current Microbiology, 62:758-763.
    24. Nimmy Augustine, Praveen Kumar and Sabu Thomas 2010. Inhibition of Vibrio cholerae biofilm by AiiA enzyme produced from Bacillus spp. Archives of Microbiology, 192 (12) 1019-1022.
    25. Praveen Kumar, Wilson Peter A and Sabu Thomas, 2010. Characterization of an SXT variant Vibrio cholerae Ogawa from a patient in Trivandrum, India. Fems Microbiol Lett, 303: 132-136.
    26. Praveen Kumar, Wilson Peter A and Sabu Thomas, 2010. Rapid detection of virulence associated genes in environmental isolates of Vibrio cholerae by multiplex PCR. Current Microbiol, 60: 199-202.
    27. Wilson Peter A, Rojan P. John, Praveen Kumar and Sabu Thomas, 2009. Tannin Acyl Hydrolyase production by Citrobacter sp. isolated from tannin rich environment, using Tamarindus indica seed power. J. Appl. Sci. Environ. Manage, 13(4)95-97.
    28. Sankar Jagadeeshan, Praveen Kumar, Wilson Peter A and Sabu Thomas, 2009. Multiresistant Environmental Vibrio cholerae non-O1/non-O139 Strains: Resistance pattern and Virulence factors, Journal of Basic Microbiology, 49,538-544.
    29. Praveen Kumar and Sabu Thomas, 2009. Presence of dfr6 gene cassette in superintegron of non-O1/non-O139 strain of Vibrio cholerae. Antimicrobial Agents Chemother, 53:4959–4960.
    30. Runa A, Krishnan KP, Sabu Thomas, Wilson Peter. A and M. Thamban, 2009. Phenotypic and molecular identification of Cellulosimicrobium cellulans isolated from Antarctic snow, Antonie van Leeuwenhoek, 96:627–634.
    31. Kumar P, Wilson Peter and Sabu Thomas, 2008. Detection of virulence genes in Vibrio cholerae isolated from aquatic environment in Kerala, Southern India. Appl Biochem Biotechnol, 151:256-62.
    32. Sabu Thomas, Dhanya R, Remani B and Singh D.V, 2007. Detection and molecular characterization of Vibrio cholerae O1 Inaba biotype El Tor strain in Kerala, S. India. World J. Microbiology and Biotechnology, 24: 433-434.
    33. Sabu Thomas, K. Harikrishnan and Sandhya C Nair. 2006. Molecular Analyis of Bacterial population in Coconut husk retting areas. Indian Journal of Biotechnology, 5: 559-561.
    34. Sabu Thomas, Harikrishnan K, Manoj N and Sandhya C. Nair. 2004. Detection and Molecular characterization of waterborne pathogenic E. coli from different water sources using Multiplex PCR. Indian Journal of Biotechnology, 3: 603-605.
    35. Paul M. R, Sabu Thomas, Sandhya C and Das M R. 2004. Impact of physico-chemical parameters on the Microbial population and its nature in a major retting zone of Kerala. International J. Environ. Studies, 61 (5): 571-578.
    36. Sabu Thomas, Harikrishnan K, Sanil George, Paulmurugan R and Das, M R. 2001. A study on the water quality of Kuttanad wetland ecosystem. Poll. Res, 20 (1): 59-66.
    37. Harikrishnan K, Sanil George, Sabu Thomas, Paulmurugan R and Das, M R. 2001. Distribution of HCH residues in Kuttanad wetland ecosystem. Ecol. Envt. Conser, 7 (1): 105-109.
    38. Sabu Thomas and Paulmurugan R, 2000. Pollution and Infectious diseases. Science India,3(6):39-42
    39. Sabu Thomas, Sandhya C N and Paulmurugan R. 2000. Drinking water quality status in Kottaracara area, Kollam district, Kerala. Ind. J. Envt. Ecoplan, 3 (1): 143- 145.
    40. Sabu Thomas and Abdul Azis P K. 2000. Physico-chemical limnology of a tropical reservoir in Kerala. Ecol. Envt. Conser, 6 (2): 159- 162.
    41. Sabu Thomas, Sanil George, Harikrishnan K, Paulmurugan R, Sathish M and Das M R.1999. Spatio-temporal distribution and ecology of benthos in the Kuttanad wetland ecosystem. Poll.Res, 18 (3):246-253.
    42. Sabu Thomas and Abdul Azis P K. 1999. Zooplankton community characteristics in a reservoir. Poll. Res, 18 (3): 257-260.
    43. Sabu Thomas and Abdul Azis P K. 1999. Status of reservoir fisheries in Kerala and strategies for the development with special reference to Peppara reservoir, Kerala. Ecol. Envt. Conser. 5 (1): 51-54.
    44. Harikrishnan K, Sabu Thomas, Sanil George, Paulmurugan R, Sathish M and Das M R. 1999. A study on the ecology and distribution of phytoplankton in the Kuttanad wetland ecosystem, Kerala. Poll. Res, 18 (3): 273-281.
    45. Sanil George, Harikrishnan, K, Sabu Thomas, Paulmurugan, R. Sathish Mundayoor and Das, M.R. 1999. Distribution of heavy metals in the Kuttanad wetland ecosystem, Kerala. India. International Journal of Ecology and Envt. Sci, 25 (1): 91 – 95.
    46. Sabu Thomas. 1998. Need and importance of environmental education in school curriculum. Ind. J. Envt. Ecoplan, 1(1&2): 77 –79.
    47. Sabu Thomas,1998. Kerala’s Aquatic resources and its protection. Swadeshi Science, 8(5):280-283.
    48. Sabu Thomas and Abdul Azis, P. K. 1998. Plankton abundance and zonal differentiation: a case study. Ind. J. Envt. Ecoplan, 1 (1&2): 21 – 25.
    49. Sabu Thomas. 1997. Limnology of a man-made reservoir on the western ghats, Kerala. American Society of Limnology and Oceanography Bulletin (ASLO-USA) 6 (2).
    50. Sabu Thomas and Abdul Azis, P. K. 1996. Spatial and temporal distribution of nutrients in a man-made ecosystem in the western ghats, S. India. Poll. Res, 15 (1): 5 –10.
    51. Sabu Thomas and Abdul Azis P.K, 1996. Conservation of reservoir fisheries in Kerala. ZOOS’PRINT,July 1996,15-16
    52. Sabu Thomas and Abdul Azis, P. K. 1996.Sediment characteristics of a man-made ecosystem in southern Kerala, J.Zool.Soc.Kerala,6&7:73-79
    53. Sabu Thomas and Abdul Azis, P. K. 1996. Seasonal variations of phytoplankton abundance. Proceedings of 8th Kerala Science Congress,Kochi,78-79
    54. Arjunan. N.K, Harikrishnan K, Shyam Kumar S and Sabu Thomas. 1996. Environmental attitude among rural and urban students. International Educator, 11 (1 &2): 20 – 22.
    55. Sabu Thomas and Abdul Azis, P. K. 1995.A study on the primary production in Peppara reservoir. Proceedings of 7th Kerala Science Congress,Palakkad,76-77
    56. Arjunan, N.K, Harikrishnan K, Shyam Kumar S and Sabu Thomas. 1995. Development and standardization of an environmental attitude scale on projective techniques. J. Educo – Ecology, 12: 1 – 5.
    57. Sabu Thomas and Abdul Azis, P. K. 1993. Volumetric estimation of planktonic biomass in relation to certain limnological conditions of freshwater bodies, J.Zool.Soc.Kerala,3(2):42-44
    1. Akhilandeswarre D and Sabu Thomas, 2016. Identification of biofilm stage specific proteins associated with multidrug resistance and quorum sensing pathway in a pandemic strain of Vibrio parahaemolyticus isolated from India.17th International Congress on Infectious Diseases, March 2-5, Hyderabad, India
    2. Karthika S, Joby John and Sabu Thomas,2016. Analysis of polymicrobial biofilm infections in non-healing diabetic ulcer. Wound Healing 2016,January 26-28,London, United Kingdom
    3. Lekshmi N and Sabu Thomas, 2015. Molecular Studies on the Haitian variant ctxB gene and cholera toxin production in Vibrio cholerae O1outbreak strains isolated from India. International Conference on Infectious Diseases and Nanomedicine December 15-18, Kathmandu, Nepal.
    4. Divya M.P and Sabu Thomas, 2015.Serological and molecular analysis of toxigenic Vibrio parahaemolyticus isolated from different environmental sources. EMBO Conference on Aquatic Microbial Ecology, August 23-25, Uppsala, Sweden.
    5. Karthika S, Joby John, Sabu Thomas. 2015. Characterization of bacterial population associated with chronic wound infections and its biofilm formation. International Symposium on New Perspectives in Modern Biotechnology, Society for Applied Biotechnology, March 23-25, Pondicherry. (Best Poster Award).
    6. Wilson Peter A and Sabu Thomas. 2015. Cold Adaptations of Bacteria from Arctic, Second International Seminar of Swami Vivekananda Association of Science and Humanities, May 22, Trivandrum
    7. Akhilandeswarre D, Eshita Mutt, Abdul Jaleel, Sowdhamini R and Sabu Thomas. 2013. Identification of potential anti-infective drug targets for Vibrio parahaemolyticus by proteomic analysis over the course of biofilm formation. 5th Annual meeting of proteomics-society-India, Indian Institute of Science, November 28-30, Bangalore.
    8. Wilson P and Sabu Thomas. 2013. Cloning and Sequencing of ccpA like gene from a Bacteria isolated from Arctic and its Molecular Identification. 54th Annual Conference of Association of Microbiology of India (AMI) International Conference FDMIR, November 7-20, Maharshi Dayanand University, Rohtak, Haryana.
    9. Karthika S, Reshma M J, Wilson P A, Anita Das R, Sarma U S, Harikrishnan K and Sabu Thomas, 2013. Characterization and evaluation of phenol degrading Bacillus consortium for enhancing the softening of coir fibre. 54th Annual Conference of Association of Microbiology of India (AMI) International Conference FDMIR, November 7-20, Maharshi Dayanand University, Rohtak, Haryana.
    10. Praveen Kumar and Sabu Thomas, 2012. Molecular characterization of Vibrio cholerae isolated from the aquatic sources in Southern Kerala, India, 15th International Congress on Infectious Diseases (ICID), June 13-16, Bangkok, Thailand
    11. Karthika S, Wilson PA, Hari Krishnan K and Sabu Thomas, 2012. Biotechnology: A Panacea for Industrial Renaissance, National Seminar on Sustainable Development through New Technologies, 12-16 August, Coir Board, Ministry of MSME. Kochi.
    12. Nimmy Augustine, Akhilandeswarre D and Sabu Thomas, 2012. Arctic Actinomycetes as potential source of  biofilm inhibitors against Vibrio cholerae. International Conference on Regulatory Network Architecture in Bacteria, SASTRA University, Mar.9-11, Thanjavur,Tamil Nadu.
    13. Nimmy Augustine and Sabu Thomas, 2011. Search of biofilm inhibitors from Actinomycetes against clinical bacterial pathogens. International Conference on Microbes in Water, Waste water, Bioremediation and Energy, Birla Institute of Technology, Jan.24-26, Goa.
    14. Runa Antony, K.P. Krishnan, Sabu Thomas, W.P. Abraham and Meloth Thamban, 2010. Cellulosimicrobium cellulans isolated from Antarctic snow and its physiological adaptations to live in extreme cold conditions, International Symposium on Microbial Ecology (ISME 13), Seatle, USA
    15. Sudha A and Sabu Thomas, 2010. Enzyme profiling and molecular characterization of psychrophilic bacterial strains isolated from the Arctic. International Conference on Genomics Science, MKU, Nov.12-14, Madurai, Tamil Nadu.
    16. Nimmy Augustine, Wilson Peter, Praveen K and Sabu Thomas, 2010. Search of Novel Compounds that do not provoke Drug Resistance in Vibrio cholerae. 14th International Conference on Emerging Infectious Disease (EID) in the Pacific Rim, Oct. 4-6, Penag, Malaysia.
    17. Praveen Kumar, Silja P.K, Wilson Peter A and Sabu Thomas, 2010. Multiresistant Vibrio cholerae non-O1/non-O139strains from S. India: Search of novel compounds that do not provoke bacterial resistance. Keystone Symposia Global Health Series on Antibiotics and Resistance: Challenges and Solutions, Feb.14-19, New Mexico, USA.
    18. Praveen Kumar, Wilson Peter A. and Sabu Thomas, 2009. Drug resistance in environmental isolates of Vibrio cholerae: Role of SXT, Class 1 and Cass 2 integrons and Superintegrons. ICAAC, Sep. 12-15, San Francisco, USA.
    19. Wilson Peter A, Wilsanand V, Praveen Kumar and Sabu Thomas, 2008. Molecular characterisation of a psychrophilic bacteria producing amylase. International Society Biotechnology Conference, at SMIT, Majitar, Dec.2008, Sikkim.
    20. Wilson Peter A, Silja P.K, Wilsanand V, Praveen K and Sabu Thomas, 2008. Characterisation of a beta-galactosidase produced from Enterobacter sp. isolated from Antarctica. 3rd International Congress on Bioprocess in Food Industries & 5th Convention of Biotech Research Society of India, Nov.6-8 at Osmania University, Hyderabad.
    21. Praveen Kumar and Sabu Thomas, 2008. Role of SXT and Class 1 integrons in conferring Multiple Drug Resistance in Environmental strains of Vibrio cholerae isolated from Kerala, S. India. Keystone Symposia on Pathogenesis and Control of Emerging Infection and Drug Resistant organisms, Oct.22-27 at Bangkok, Thailand.
    22. Wilson Peter A, Wilsanand V, Praveen Kumar, Bibin T and Sabu Thomas,2007. Screening of a novel psychrophilic strain producing cold active beta galactosidase and its molecular characterization. National seminar on Microbes: Biofactories of future, 18-21 Dec. Dept. of Biotechnology, IIT, Chennai.
    23. Praveen Kumar, Wilson Peter A and Sabu Thomas, 2007. Detection of virulence genes in Vibrio cholerae non-O1/non O139 strains isolated from aquatic sources of Kerala, S. India. International Conference on New Horizons in Biotechnology, Trivandrum, Kerala. 
    24. Wilson Peter A, Wilsanand V, Praveen Kumar, Bibin T and Sabu Thomas.2007. Screening of a novel psychrophilic strain producing cold active beta galactosidase and its molecular characterization. National seminar on Microbes: Biofact
    1. Sudha A, Wilson P.A and Sabu Thomas, 2012. Psychrophiles - A plethora of perspectives. Bacterial Biochemistry and Biotechnology. Lambert Academic Publishing. pp. 158-167.
    2. S. Princy Adline, Srinath N, Sajal Shrivastava and Sabu Thomas, 2010. Vibrio cholerae biofilm and virulence gene expression: A perception towards quorum sensing. In Cholera: Symptoms, Diagnosis and Treatment. (Eds.Evelyn L. Melbourne) Nova Science Publishers Inc. Hauppauge, NY, USA. pp. 123-133.
    3. S. Princy Adline, R. Vinothkannan, Rekha Arya and Sabu Thomas, 2010. Quorum Quenching: Imminent Targets in Vibrio cholerae. In Cholera: Symptoms, Diagnosis and Treatment. (Eds.Evelyn L. Melbourne) Nova Science Publishers Inc. Hauppauge, NY, USA. pp. 109-122.
    4. Sabu Thomas, S Jagadeeshan, P Kumar, Sathish Mundayoor and Yung Tse, 2010. Drinking Water Associated Pathology. Hand Book of Environmental and Waste Management, Volume 1 -Air and Water Pollution Control. (Eds. Yung-Tse Hung, Lawrence K. Wang, Nazih K. Shammas, USA). World Scientific Publishing Co. Pte. Ltd, Singapore.
    5. Jagadeeshan S, P. Kumar, WP Abraham and Sabu Thomas, 2009. The emerging multiple antibiotic resistance pattern in the environmental isolates of Vibrio cholerae isolated from S. Kerala. Antimicrobial Resistance: from Emerging Threat to Reality (Eds. Rubina Lawrence, Anil K Gulati, Gerrard Abraham). Narosa Publishing House Pvt. Ltd. New Delhi; pp. 241-245.
    6. Sabu Thomas, Praveen PP, Wilson P.A, Bibin T and Singh D.V, 2007. Molecular monitoring of Vibrio cholerae in the aquatic environments of Kerala. Environment & Human Health, Rajiv Gandhi Chair Pub.2 (Eds. Dr. P. Natarajan, Dr. C.S. Paulose, Dr. I.S. Bright Singh and Ms. Pillai Raji K), pp. 67-77.
    7. Sabu Thomas, Sandhya C Nair and R. Paul Murugan, 2002. A study on the water quality and microbiology profile of Sasthamkotta freshwater lake in Kollam district, Kerala. Ecology and Conservation of Lakes, Reservoirs and Rivers,(Ed. Dr. Arvind Kumar) pp.299-302.
    8. Sabu Thomas, 2002. Reservoirs of Kerala-Their unique potential and problems. Ecology and Conservation of Lakes, Reservoirs and Rivers,(Ed. Dr. Arvind Kumar) pp.620-629.
    9. Sabu Thomas, 2002. Benthic composition, Abundance and Zonal differentiation in the Peppara reservoir, S.Kerala, India,. Ecology and Conservation of Lakes, Reservoirs and Rivers,(Ed. Dr. Arvind Kumar) pp.630-635.

    Bacterial Whole Genome & Metagenome Sequence Submission

    1. Akhilandeswaree D & Sabu Thomas. Pseudomonas brenneri strain RGCB 108, whole genome shotgun sequencing project, Bioproject: PRJNA315753, Biosample: SAMN04569815 Acc no. LUXZ00000000 
    2. Akhilandeswaree D & Sabu Thomas. Pseudomonas simiae strain RGCB 73, whole genome shotgun sequencing project. Bioproject: PRJNA307220, Biosample:SAMN04517449 Acc no. LVWZ00000000.
    3. Wilson P A & Sabu Thomas. Pseudomonas psychrophila strain RGCB 166, whole genome shotgun sequencing project. Bioproject:PRJNA278112, Biosample: SAMN03406680, Acc. No. LBHT00000000, Contigs Acc. No. LBHT01000001-LBHT01000150.
    4. Divya M.P and Sabu Thomas. Draft Genome Sequence of an Environmental Vibrio parahaemolyticus K23. Bioproject: PRJNA285022, Biosample: SAMN03735013, Acc.No. LQGU00000000
    5. Karthika S & Sabu Thomas.  Metagenome of Diabetic Ulcer. SRA Acc. no.: SRX1453631, Bioproject: PRJNA304366, Biosample: SAMN04299664

    PRIDE Archive Submission

    1. Comparitive Proteome analysis of Vibrio parahaemolyticus during planktonic and biofilm stages, Project Acc. no. PXD004354

    Genbank Submissions

    1. Pseudomonas psychrophila strain 166. 16S ribosomal RNA gene, partial sequence.Accession number. JX271040
    2. Cold shock protein from Psychrobacter sp. 331 isolated from Arctic sediment.Acc. no. JN024699
    3. Enterobacter spp. psychrophillic strains 16S rRNA gene sequence. Acc. nos. EU391589, FJ463411, FJ463410.
    4. Psychrotrophic bacteria from fjord water and sediments of Ny-Alesund area, Arctic.
      Acc. nos. KP204033-KP204050.
    5. A novel variant of tcpA gene from environmental strain of Vibrio cholerae, non-O1/non-O139.Acc. no. EU362122.
    6. Vibrio cholerae non-O1/nonO139 strain AMVC 16S ribosomal RNA gene, partial sequence. Acc. no JX987303.1
    7. Vibrio cholerae O1 biovar El Tor strains VCW4, C1, C3, C5 cholera enterotoxin B-subunit (ctxB) gene, complete cds. Acc. nos. KF042305-KF042308 respectively.
    8. Vibrio cholerae O1 biovar El Tor strains VCW4, C1, C3, C5 DNA topoisomerase IV subunit A (parC) gene, partial cds. Acc. nos. KF741367-KF741370 respectively.
    9. Wohlfahrtiimonas chitiniclastica strain SK202 16S ribosomal RNA   gene partial sequence. Acc. no KM030600.
    10. Bacillus thuringiensis strain S19, Bacillus stratosphericus strain S6, Bacillus licheniformis strain S9, Bacillus sp. S16 16S ribosomal RNA gene, partial sequence. Acc.nos.KF052984 KF052987respectively.
    11. Streptomyces sp. A742 16S ribosomal RNA gene, partial sequence. Acc. no. KC153537.
    1. Sabu Thomas, 2016. Molecular epidemiology of V. cholerae and its biofilm mode of life. 2nd International Microbial Biotechnology Conference, Atma Jaya Catholic University of Indonesia, Nov.15-16, Jakarta
    2. Sabu Thomas, 2016. Chaired a scientific session in Probiotics, IMBC at Atma Jaya Catholic University of Indonesia, Nov.15-16, Jakarta
    3. Sabu Thomas, 2016. Food Safety related with Vibrios and other Enteropathogens, Dept. of Food Microbiology, Atma Jaya University, Nov.17,Jakarta, Indonesia
    4. Sabu Thomas, 2016. Surveillance of cholera in south India. Cholera surveillance network: Evidence for Cholera in India, Nov. 22, THSTI, Faridabad
    5. Sabu Thomas, 2015. Review of the cholera research program in RGCB emphasizing the importance of Environmental surveillance of Vibrio cholerae   and control of cholera. In the Secretariat of the Global Task Force on Cholera Control (GTFCC) Working Group on Laboratory Methods, organized by Dept. of Pandemic and Epidemic Diseases, World Health Organization. November 26-27, THSTI, Faridabad.
    6. Sabu Thomas, 2015. Biotechnology for a Better Tomorrow, November 4, S.G. College, Kottaracara, Organised by the Dept. of Zoology.
    7. Sabu Thomas, 2015. Identification of broad-spectrum antibiofilm drug targets: An integrated omic approach. September11, Sree Buddha College of Engineering, Pandalam.
    8. Sabu Thomas, 2015. Science and Inventions: Foundation for Smart Living: Walk With A Scholar Programme, February 21, S.G. College, Kottaracara, Organised by Directorate of Collegiate Education, Govt. of Kerala.
    9. Sabu Thomas,2014. Safeguarding the Environment using Bioremediation-A Biotechnological Approach. National Seminar on Translational Biotechnology for a Better Tomorrow,3-4 September, Organised by St.Peter’s College, Kolenchery, Sponsored by UGC.
    10. Sabu Thomas, 2014. Trends in Biotechnology towards Bioconservation, National Conference on Recent Trends in Biosciences- Challenges and Future Prospects, 13-15 March. Mar Thoma College of Science and Technology, Ayur, Sponsored by KSCSTE, Govt. of Kerala.
    11. Sabu Thomas, 2014. Inaugurated the training workshop on Qualitative research, techniques and data analysis using open source tools, March 28-30. Nodal office, Trivandrum of the Christ University, Bangalore.
    12. Sabu Thomas, 2013. Biotechnology and Environmental Conservation- a perspective, National seminar on Biological conservation and sustainability: Issues and Strategies, August, K.G College, Pampady.
    13. Sabu Thomas, 2012. Biotechnology: A Panacea for Industrial Renaissance, International Coir Tech Expo, 12-16 August, Kochi.
    14. Sabu Thomas, 2011. Indian Arctic Expedition Experiences, Meet the Scientist Programme- Love Dale Residential School, November 22, Attingal.
    15. SabuThomas, 2010. Arctic Biodiversity, TRENDZ 2010, December 9, S.N.College, Varkala.
    16. Sabu Thomas,2010. Indian Arctic Expedition Experiences, December 12, Catholicate College,Pathanamthitta
    17. Sabu Thomas, 2009. Search of Actinomycetes showing biofilm inhibition in non-O1/ non-O139 Vibrio cholerae O110. International Symposium on 50 years of Discovery of Cholera Toxin: A Tribute to S.N. De, Oct. 25-27, Kolkata.
    18. Sabu Thomas, 2009. The emerging multiple antibiotic resistance pattern in the environmental isolates of Vibrio cholerae isolated from South Kerala. National conference on Antimicrobial Resistance: from Emerging Threat to Reality at Allahabad Agricultural Institute Deemed University, 23-25 March. Allahabad.
    19. Sabu Thomas, 2009. Biotechnology and Biomedical Techniques, January 9, St. Mary’s Higher Secondary School, Pattom, Trivandrum.
    20. Sabu Thomas,2009. Tissue Culture and Modern Trends in Biotechnology, January 19, Govt. Higher Secondary School, Mancode,Pathanamthitta
    21. Sabu Thomas, 2008. Biotechnology and its applications with special reference to Environmental Conservation. National Seminar on Biotechnology for a Clean Environment, October 15-16, S.N. College, Kollam. Sponsored by UGC.
    22. Sabu Thomas, 2007. Molecular Epidemiology of Vibrio cholerae, National Seminar on Emerging Trends in Microbiology & Bioinformatics, October 17, CMS College of Science & Commerce, Coimbatore.
    23. Sabu Thomas, 2006. Role of Biotechnology for sustainable development  and Environmental Conservation, National Seminar on Challenges for Green Environment, February 22, Karpagam Arts and Science College, Coimbatore.
    24. Sabu Thomas, 2006. Perspectives in Environmental Biotechnology, UGC Orientation Course for College Teachers, Academic Staff College, January 28, University of Kerala, Trivandrum.
    25. Sabu Thomas, 2006. Nurture, Nature for Future, in connection with the National Science Day celebrations at Govt. HSS, 28th February, Anchalumoodu, Kollam. Organized by KSCSTE and RGCB
    26. Sabu Thomas, 2005. Perspectives in Environmental Biotechnology, UGC Orientation Course for College Teachers, Academic Staff College, August 3, University of Kerala, Trivandrum.
    27. Sabu Thomas,2003. Water Resources of Kerala-Its pollution and bioremediation, in a Seminar on Environmental Awareness . 1st May, Panmana Ashram, , Kollam
    28. Sabu Thomas, 2002. Salient features of Kallada River-A case study, Seminar on sand mining and conservation of river basin, February 18, Centre for Natural Resource Management, Kottarakara.
    29. Sabu Thomas, 2001. Aquatic Resources and its Conservation, National Green Corps- District Level Teachers Training, November 20-21,DIET, Kottarakara, MoEF and KSCSTE.
  • Team


    Divya M P ,PhD student (ICMR Fellow)

    Molecular characterisation of environmental Vibrio parahaemolyticus and study of its pathogenicity

    Vibrio parahaemolyticus is recognized as a worldwide cause of food-borne gastroenteritis. The majority of isolates derived from environmental sources are believed to be non-pathogenic compared to the clinical strains that carry the toxin genes. The purpose of this study is to investigate genetic diversity and pathogenicity of V.parahaemolyticus isolates from environmental sources and understand the distinction between clinical and environmental isolates of this dynamic pathogen.

    divya
    divya

    Divya M P ,PhD student (ICMR Fellow)

    Molecular characterisation of environmental Vibrio parahaemolyticus and study of its pathogenicity

    Vibrio parahaemolyticus is recognized as a worldwide cause of food-borne gastroenteritis. The majority of isolates derived from environmental sources are believed to be non-pathogenic compared to the clinical strains that carry the toxin genes. The purpose of this study is to investigate genetic diversity and pathogenicity of V.parahaemolyticus isolates from environmental sources and understand the distinction between clinical and environmental isolates of this dynamic pathogen.

    Akhilandeswarre D ,PhD student (INSPIRE Fellow)

    Identification of conserved target for inhibiting biofilm formation in Vibrio cholera and Vibrio parahaemolyticus

    Treating the infections caused by Vibrio cholera and Vibrio parahaemolyticus is complicated by the biofilm mode of life adapted by the microbes. Biofilm associated microbes are highly resistant to antimicrobial agents and host immune responses. My study aims at identifying conserved target for inhibiting biofilm formation employing transcriptomic and proteomic approaches. The identified targets could be used in computational based drug discovery approaches for accelerating the discovery of broad-spectrum anti-biofilm drugs.

    Akhilandeswarre
    Akhilandeswarre

    Akhilandeswarre D ,PhD student (INSPIRE Fellow)

    Identification of conserved target for inhibiting biofilm formation in Vibrio cholera and Vibrio parahaemolyticus

    Treating the infections caused by Vibrio cholera and Vibrio parahaemolyticus is complicated by the biofilm mode of life adapted by the microbes. Biofilm associated microbes are highly resistant to antimicrobial agents and host immune responses. My study aims at identifying conserved target for inhibiting biofilm formation employing transcriptomic and proteomic approaches. The identified targets could be used in computational based drug discovery approaches for accelerating the discovery of broad-spectrum anti-biofilm drugs.

    Lekshmi N, PhD student (INSPIRE Fellow)

    Studies on the Haitian variant Vibrio cholerae with special emphasis on its pathogenesis, antibiotic resistance and comparative genomics

    The major threat the world faces today in cholera treatment is the newly emerging variants of Vibrio cholerae that are conferred with high virulence, transmission and development of multidrug resistance. The molecular nature of these variants and the severity of the disease caused by these variant organisms are not yet well explored. The main aim of my study is to understand the variation in pathogenicity if any and the antibiotic resistance progression in the emerging Vibrio cholerae variants particularly those of recent outbreaks from South India.

    lekshmi
    lekshmi

    Lekshmi N, PhD student (INSPIRE Fellow)

    Studies on the Haitian variant Vibrio cholerae with special emphasis on its pathogenesis, antibiotic resistance and comparative genomics

    The major threat the world faces today in cholera treatment is the newly emerging variants of Vibrio cholerae that are conferred with high virulence, transmission and development of multidrug resistance. The molecular nature of these variants and the severity of the disease caused by these variant organisms are not yet well explored. The main aim of my study is to understand the variation in pathogenicity if any and the antibiotic resistance progression in the emerging Vibrio cholerae variants particularly those of recent outbreaks from South India.

    Devika Das J, PhD student (INSPIRE Fellow)

    Anti-infectious property of potential probiotic strains of human origin against Vibrio cholerae

    Diarrhoel diseases like cholera still remain as a grave public health problem and its serious recrudescence in many developing countries is a matter of major concern. This study focuses on exploring the anti-infectious potential of indigenous gut microflora of human origin for the development of a safe probiotic therapy against the diarrhoel disease, cholera. The identified probiotic strains can be taken forward for formulation of a cost effective, novel probiotic therapy to control the disease.

    Devika
    Devika

    Devika Das J, PhD student (INSPIRE Fellow)

    Anti-infectious property of potential probiotic strains of human origin against Vibrio cholerae

    Diarrhoel diseases like cholera still remain as a grave public health problem and its serious recrudescence in many developing countries is a matter of major concern. This study focuses on exploring the anti-infectious potential of indigenous gut microflora of human origin for the development of a safe probiotic therapy against the diarrhoel disease, cholera. The identified probiotic strains can be taken forward for formulation of a cost effective, novel probiotic therapy to control the disease.

    Karthika S ,PhD student (KSCSTE Fellow)

    Characterization of polymicrobial communities and its biofilm matrix associated components in chronic Diabetic ulcer

    Bacterial biofilms are the unrecognized but important barrier that impairs the healing of chronic wounds in clinical settings. I am focusing on the molecular characterization of polymicrobial communities, its biofilm associated proteins and organization and sharing of biofilm matrix components among predominant bacteria in chronic diabetic ulcer infections. Since there is a significant increase in clinical reports concerning to various chronic wound related ailments, the present study would provide insight into the bacterial biofilm architecture which is required for proper diagnosis and effective treatment of such infections.

    karthika
    karthika

    Karthika S ,PhD student (KSCSTE Fellow)

    Characterization of polymicrobial communities and its biofilm matrix associated components in chronic Diabetic ulcer

    Bacterial biofilms are the unrecognized but important barrier that impairs the healing of chronic wounds in clinical settings. I am focusing on the molecular characterization of polymicrobial communities, its biofilm associated proteins and organization and sharing of biofilm matrix components among predominant bacteria in chronic diabetic ulcer infections. Since there is a significant increase in clinical reports concerning to various chronic wound related ailments, the present study would provide insight into the bacterial biofilm architecture which is required for proper diagnosis and effective treatment of such infections.

    Deepa Mathew P, Research Assistant

    Molecular analysis of environmental Vibrio cholerae

    We determine the clonality and changes taking place with time in the genome and how the different strains are related to one another and hence to track the molecular changes occurring in cholera toxin gene which give rise to newer variants of V.cholerae.

    DEEPA M
    DEEPA M

    Deepa Mathew P, Research Assistant

    Molecular analysis of environmental Vibrio cholerae

    We determine the clonality and changes taking place with time in the genome and how the different strains are related to one another and hence to track the molecular changes occurring in cholera toxin gene which give rise to newer variants of V.cholerae.

    Wilson Peter Abraham ,PhD student

    Molecular studies on cold adaptation of Pseudomonas psychrophilla isolated from Arctic

    The main objective of my study is to understand cold adaptation in bacteria isolated from Arctic. In order to study the cold adaptation mechanisms, genome and proteome analysis of a model organism will be explored. This study will throw light on the complicated cold adaptation mechanisms and as a model system to unravel their molecular basis of survival and multiplication at low temperatures.

    Wilson Peter
    Wilson Peter

    Wilson Peter Abraham ,PhD student

    Molecular studies on cold adaptation of Pseudomonas psychrophilla isolated from Arctic

    The main objective of my study is to understand cold adaptation in bacteria isolated from Arctic. In order to study the cold adaptation mechanisms, genome and proteome analysis of a model organism will be explored. This study will throw light on the complicated cold adaptation mechanisms and as a model system to unravel their molecular basis of survival and multiplication at low temperatures.

    Megha PR, Junior Research Fellow (DBT)

    Analysis of polymicrobial biofilms in chronic wound infections and development of anti-biofilm therapeutic to promote wound healing

    Chronic wound infections affect millions of people suffering from diabetes, venous insufficiency and bed sore. Studies revealed that chronicity of wound is directly linked to polymicrobial communities and its biofilm mode of infection. As the biofilm associated microbes are highly resistant to antibiotics, the present treatment strategies may not be sufficient to heal the wound. This study focuses on diversity of polymicrobial communities in the wound biofilms and the biofilm matrix associated proteins produced by the coexisting bacteria. A better understanding of the extracellular matrix and proposing an anti-biofilm compound is necessary to enable the development of next generation therapeutics. The study regarding the gene expressions of predominant pathogens in mixed species biofilm will help to generate in-depth idea regarding the polymicrobial interactions within a biofilm.

    Wilson Peter
    Wilson Peter

    Megha PR, Junior Research Fellow (DBT)

    Analysis of polymicrobial biofilms in chronic wound infections and development of anti-biofilm therapeutic to promote wound healing

    Chronic wound infections affect millions of people suffering from diabetes, venous insufficiency and bed sore. Studies revealed that chronicity of wound is directly linked to polymicrobial communities and its biofilm mode of infection. As the biofilm associated microbes are highly resistant to antibiotics, the present treatment strategies may not be sufficient to heal the wound. This study focuses on diversity of polymicrobial communities in the wound biofilms and the biofilm matrix associated proteins produced by the coexisting bacteria. A better understanding of the extracellular matrix and proposing an anti-biofilm compound is necessary to enable the development of next generation therapeutics. The study regarding the gene expressions of predominant pathogens in mixed species biofilm will help to generate in-depth idea regarding the polymicrobial interactions within a biofilm.

  • Alumni


    Mr. Bibin Thomas

    Junior Research Fellow
    Currently: Dublin, Ireland

    Bibin Thomas
    Bibin Thomas

    Mr. Bibin Thomas

    Junior Research Fellow
    Currently: Dublin, Ireland

    Dr. Praveen Kumar P.P

    PhD student
    Currently: Assistant Professor
    Govt. College for Women, Thiruvananthapuram

    PRAVEEN KUMAR
    PRAVEEN KUMAR

    Dr. Praveen Kumar P.P

    PhD student
    Currently: Assistant Professor
    Govt. College for Women, Thiruvananthapuram

    Mrs. Sudha A

    Junior Research Fellow
    Currently: Michigan, USA

    sudha
    sudha

    Mrs. Sudha A

    Junior Research Fellow
    Currently: Michigan, USA

    Mrs. Sandhya C Nair

    Senior Technical Officer

    SANDHYA C NAIR
    SANDHYA C NAIR

    Mrs. Sandhya C Nair

    Senior Technical Officer

    Mrs. Nimmy Augustine

    Junior Research Fellow

    NIMMY AUGUSTINE
    NIMMY AUGUSTINE

    Mrs. Nimmy Augustine

    Junior Research Fellow

    Ms. Diana Jose

    Junior Research Fellow

    Diana Jose
    Diana Jose

    Ms. Diana Jose

    Junior Research Fellow

    Ms. Sreeja S

    Research Assistant

    Bibin Thomas
    Bibin Thomas

    Ms. Sreeja S

    Research Assistant