Dr. Shyla G, Verghese KurianYoung Scientist scheme, KSCSTE
Transcriptome Profiling and functional analysis of frog skin derived host defense peptides
Research on naturally expressing host defence peptides are now attaining momentum since they represent a viable and productive area for drug discovery. In highly competitive environment of the current pharmaceutical industry, natural HDPs provide a unique important element with functional and molecular diversity, which is crucial for drug discovery. Isolation of new AMPs and their structure-function studies may form the basis for the generation of new peptides or peptide analogues based drugs for the treatment of various diseases. My work is aimed to idenetify and characterize the host defence peptides derived from the skin secretion of the endemic frogs of Western Ghats, India. Peptides were identified through transcriptomic approach and the identified peptides will be characterized with various assays to evaluate their bilological activities and mode of action with a view to develop lead molecules for therapeutic applications.