Gene expression analysis of nidus of cerebral arteriovenous malformations reveals vascular structures with deficient differentiation and maturation

PLoS One  Published: June 13, 2018 | https://doi.org/10.1371/journal.pone.0198617  

Jaya Mary Thomas, Sumi Surendran, Mathew Abraham, Dhakshmi Sasankan, Sridutt Bhaadri, Arumugam Rajavelu, Chandrasekharan C. Kartha

Abstract

Arteriovenous malformations (AVMs) are characterised by tangles of dysplastic blood vessels which shunt blood from arteries to veins with no intervening capillary bed. It is not known at what stage of development and differentiation, AVM vessels became aberrant. To address this, we have analysed the expression of vascular differentiation, vascular maturation and brain capillary specific genes in AVM nidus.

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