Surya Ramachandran, PhD
Program Scientist, Diabetes Research Program
Surya Ramachandran, PhD
Program Scientist, Diabetes Research Program
- PhD in Microbiology/Tumour Biology – 2009 (Regional Cancer Centre, Thiruvananthapuram/Mahatma Gandhi University)
- MSc Microbiology – 1998 (ManonmaniamSundaranar University, Tirunelveli)
- BSc Botany – 1996 (University of Kerala)
- Awarded third prize for poster presentation at Women Scientists & Entrepreneurs Conclave, India International Science Festival-2017, Chennai, October 15-16, 2017
- ISHR-Torrent Young Investigator Award 2017 for oral poster presentation at Cardiovascular Research Convergence, Translational Health Science & Technology Institute, Faridabad, India 12 August, 2017
- Reviewer, Scientific Reports, published by Nature Publishing Group
- Reviewer, Proteomics, published by Wiley online library
- Reviewer, PLOS ONE published by Public Library of Science
- Invited speaker, International conference on recent advances in cardiovascular research: Impact on Health and Disease, VPCI, New Delhi, 9-11 Feb, 2017
- Invited speaker, 8th International Conference on Translational Research in Cardiovascular Sciences at Anand, Gujarat, February 2016
- Editorial board member, Molecular and Cellular Biochemistry, an International Journal for Chemical Biology in Health and Disease, Springer Journals September 2015 – September 2018
- Finalist at the Kern Wildenthal Young Faculty Competition (Translational Medicine) at 3rd Forum to Promote Young Investigators and Centers of Excellence in Cardiovascular Research, International Academy of Cardiovascular Sciences, Creighton University Harper Center, Omaha, NE, USA, 10 -12 September 2015
- Distinguished Service Award in Cardiovascular Science Medicine and Surgery; International Academy of Cardiovascular Sciences, Canada, March 2015
- Invited Speaker, Indo-US Symposium on Metabolomics and Disease Biology, Poovar Island resorts, January 22-23, 2014
- Visiting Scientist fellowship, Oklahoma Medical Research foundation, Oklahoma, USA (May 2012-August 2012)
- Post-doctoral Fellowship (DBT-PDF) by the Department of Biotechnology, Government of India, 2009
- DBT International Travel Fellowship to present at the Second World Congress of Oral Oncology, Toronto, July 2009
- RGCB Merit Award of the Year 2008
- Senior Research Fellowship (SRF) awarded by Indian Council for Medical Research (ICMR) 2006
- Secretary General, International Academy of Cardiovascular Sciences-India Section
- Life member, International Society for Heart Research
- Member, Indian Society for Cell Biology, India
- Member, Indian Society for Chemical Biology, India
- Visiting Scientist, Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, USA (May-August 2012)
- Department of Biotechnology- Research Associate, Cardiovascular Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram (2009-2012)
- Training in LC-Tandem Mass Spectrometry& Proteomic Technologies, Oklahoma Medical Research Foundation, Oklahoma, USA, 2012
- Training in MALDI-MS, MALDI-MS/MS, LC ESI MS/MS, ESI-MS at Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 2010
- Facilitation Workshop conducted by The Centre for Chronic Disease Control, New Delhi along with Emory University of USA funded by National Institute of Health, USA, on identifying research questions and developing proposals on the epidemiology and prevention of NCD across the life-course, Hyderabad, 2009
- Summer workshop on "Research Methodology and Application of SPSS for Data Analysis" conducted by Albertian Institute of Management, Ernakulam, 2008
- School Program: Organized “Promotion of heart health among children (PRO♥C)” to create awareness about prevention of heart disease by leading a healthy and wise lifestyle from young age among school children of classes 8 and 9 in various schools of Kerala as part of activities of the Academy of Cardiovascular Sciences (IACS-India section). www.cardiovascularsciences.org
- Matters of the Heart: Associate editor of Matters of the Heart, newsletter of Academy of Cardiovascular Sciences designed to provide scientific information in a simple format for the layman.
- Public forum: Conceptualized and organized an outreach program for the general public on 12th March, 2015 to educate the layman on heart diseases and conditions leading to heart failure at MR Das Hall, Rajiv Gandhi Centre for Biotechnology.
- Diabetes Camp: Organized a “Diabetes Awareness and Detection Camp” for staff and students of Rajiv Gandhi Centre for Biotechnology on 27th April 2012 in association with Indian Institute of Diabetes, Trivandrum.
- Monocyte proteins as markers of vascular disease in type 2 diabetes
- The Gut Microbiome: Role in diabetes and associated vascular disease
Inflammation and oxidative stress are pathogenic mediators of many diseases, especially cardiovascular complications associated with diabetes. Cardiovascular diseases account for nearly 85 percent of deaths in patients with type 2 diabetes mellitus. While presence of cardiovascular disease can be detected, there are no widely accepted biomarkers for screening and identifying individuals at risk for early vascular disease in patients with type 2 diabetes. My research is targeted on circulating monocytes which is a key player initiating atherogenic vascular disease in diabetes. We focus on monocyte proteins which could serve as individual markers or define a characteristic high risk profile. A major area of research in our laboratory is exploring our gut microbial communities to understand its involvement in the regulation of immune-inflammatory pathways. The gut microbiome plays an important role initiating the inflammatory state of insulin resistance through the activity of lipopolysaccharide (LPS), a component of the gram-negative bacterial cell walls, which can trigger the inflammatory process by secretion of inflammatory cytokines. These circulating cytokines interact with specific receptors on cells and activate various signaling pathways leading to vascular dysfunction. We concentrate on the immune-inflammatory response of human monocytes to the gut microbiota at the molecular, genetic and in vivo level.
- Ramachandran S, Vinitha A, CC Kartha. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions; a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovascular Diabetology 2016 15:152
- Kuriakose MA, Ramdas K, Dey B, Iyer S, Rajan G, Elango KK, Suresh A, Ravindran D, Kumar RR, R P, Ramachandran S, Kumar NA, Thomas G, Somanathan T, Ravindran HK, Ranganathan K, Katakam SB, Parashuram S, Jayaprakash V, Pillai MRA Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia. Cancer Prev Res (Phila). 2016 Aug;9(8):683-91. doi: 10.1158/1940-6207.CAPR-15-0390. Epub 2016 Jun 7.
- Sumi, S., S. Ramachandran, et al. (2017). "ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus." Molecular and Cellular Biochemistry 435(1): 67-72
- Vinitha A, Kutty VR, Vivekanand A, Reshmi G, Divya G, Sumi S, Santosh KR, Pratapachandran NS, Ajit MS, Kartha CC, Ramachandran S. PPIA rs6850: A > G single-nucleotide polymorphism is associated with raised plasma cyclophilin A levels in patients with coronary artery disease. Mol Cell Biochem. 2015 Dec 24:1-10
- S Sumi, S Ramachandran, VR Kutty, MM Patel, T Anand, A Mullassari, CC Kartha Nonsynonymous T280M gene variant of CX3CR1 in South Indian population is associated with reduced risk for vascular disease in diabetes mellitus. Current Research Cardiology 2015 2;4:188-192 (Equal first author)
- Ramachandran S, Venugopal A, Ramankutty V, Vinitha A, Divya G, V Chitrasree, Ajit Mullassari, N S Pratap Chandran, K R Santosh, M Radhakrishna Pillai, C C Kartha. Plasma Level of Cyclophilin A is Increased in Patients with Type 2 Diabetes Mellitus and Suggests Presence of Vascular Disease. Cardiovasc Diabetol. 2014 Feb 7;13:38
- Kumar MM, Adurthi S, Ramachandran S, Mukherjee G, Joy O, Krishnamurthy H, Krishna S, Bafna UD, Uma DK, Jayshree RS. Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy. Int J Gynecol Cancer. 2013 Jan;23(1):184-92. doi: 10.1097/IGC.0b013e31827a2003
- Ramachandran S, Venugopal A, K S, G R, Charles S, G D, Chandran NS, Mullassari A, Pillai MR, Kartha CC. Proteomic profiling of high glucose primed monocytes identifies cyclophilin A as a potential secretory marker of inflammation in type 2 diabetes. Proteomics. 2012;12(18):2808-21
- Ramachandran S, Kartha CC. Cyclophilin-A: a potential screening marker for vascular disease in type-2 diabetes.Can J PhysiolPharmacol. 2012 Aug;90(8):1005-15
- Reshmi G, Charles S, James P, Jijith VS, Prathibha R, Ramachandran S, Divya R, Ramadas K, Radhakrishna Pillai M. OrCa-dB: a complete catalogue of molecular and clinical information in oral carcinogenesis. Oral Oncol. 2012Jun;48(6):e19. Epub 2012 Feb 25.
- G S Ajithkumar, Surya Ramachandran, C C Kartha. Drug induced endothelial dysfunction: functional role of oxidative stress. IIOABJ. 2011; Vol. 2 (5): 62-70.
- Reshmi G, Surya R, Jissa VT, Babu PS, Preethi NR, Santhi WS, Jayaprakash PG, Pillai MR. C-T variant in a miRNA target site of BCL2 is associated with increased risk of human papilloma virus related cervical cancer–an in silico approach. Genomics. 2011;98(3):189-93
- Reshmi G, Vinod Chandra S. S, Janki Mohan Babu V, SaneeshBabu P S, Santhi W.S, Surya Ramachandran, Lakshmi S., Achuthsankar S. Nair M. Radhakrishna Pillai. “Identification and analysis of novel microRNAs from Fragile Sites of Human Cervical Cancer: Computational and Experimental Approach”. Genomics. 2011; 97(6):333-40.
- A.G. Unnikrishnan, S. Ramachandran, M.R. Pillai, H. Kumar, P. Nair, R.V. Jayakumar, U. Guruprasad, R. Nandakumar, T. Joseph, I. Hariharan, V. Balakrishnan. Analysis of GSTM1 and CYP1A1 Genes in Tropical Chronic Pancreatitis: A Pilot Study. Indian Journal of Endocrinology & Metabolism 2008,12(5):3-6
- Ramachandran S, Ramadas K, Hariharan R, Rejnish Kumar R, Radhakrishna Pillai M. Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer. Oral Oncol. 2006;42(4):350-62.
- Mechanisms of Vascular Defects in Diabetes Mellitus. CC Kartha, S Ramachandran, RM Pillai - Advances in Biochemistry in Health and Disease, vol 17. Springer, Cham
- Ramachandran S, Pillai R.M., Kartha C.C. (2017) Monocyte Factors in Pathogenesis of Vascular Lesions in Diabetes. In: Kartha C., Ramachandran S., Pillai R. (eds) Mechanisms of Vascular Defects in Diabetes Mellitus. Advances in Biochemistry in Health and Disease, vol 17. Springer, Cham