Dr. Renjini A. P, Research Associate – Level III(DST)
Deciphering the role of ER alpha in modulating the strength of STAT3 function.
Steroid signaling during window of implantation becomes indispensible for defining unique molecular signatures and protein networks. The uterus and the blastocyst perform dynamic homework to achieve implantation. The steroid hormone estrogen is crucial for the process of implantation and epithelial proliferation as it specifies the duration of the window of uterine receptivity for implantation. ERa, the mediator of estrogen action, is the predominant form in the murine uterus. Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor during implantation acting as mediator of various cytokines. ERa interaction with STAT3 has been well documented in cancer. In this project we would try to see whether STAT3 associates with ERa, identify if the LXXLL Motif in STAT3 is responsible for this interaction and decipher the functional significance of ER-STAT3 interaction during embryo implantation.