Hezlin Marzook, MSc, PhD student
My work under the co-mentorship of Professors Rakesh Kumar and M. Radhakrishna Pillai focuses on the Metastasis Associated Tumor Antigen 1 (MTA1) which is a chromatin modifier protein found widely up regulated in a variety of human cancers. I study the role of MTA1 in tumor progression under stressed conditions. We suspect the involvement of MTA1 in imparting a pro-survival mechanism during stressed conditions in cancer cells. It is possible that MTA1 may have a protective role against stress, presumably, due to its ability to regulate a sub-set of relevant genes which are in the nuclear compartment, the mechanistic insights of which is yet unknown and form an aim of the present study.