Annexin V-Based Bead System for Apoptotic Cell Detection and Depletion
Overview
Brief Description: This technology provides a cost-effective, multiplatform-compatible bead-based system specifically designed for the detection and depletion of apoptotic cells, particularly by utilizing Annexin V fluorescent conjugates to identify apoptosis through the quantification of phosphatidylserine on apoptotic cell surfaces.
Development Stage: The technology is currently at a commercially available stage, having been tested and validated for practical applications in various biological studies and clinical products.
Key Features
- Multiplatform Compatibility: The technology is adaptable for use with multiple platforms including fluorescent microscopy and flow cytometry.
- Dual Functionality: This system detects and allows depletion of apoptotic cells.
- Immunomagnetic Approach: Utilizes Annexin V with magnetic beads for efficient dead cell elimination.
Benefits
- Economic Impact: Reduces cost and improves efficiency.
- Social Impact: Enhances safety and efficacy of therapies.
- Environmental Impact: Reduces reagent consumption and waste.
Applications
- Pharmaceuticals: Drug discovery and cytotoxicity testing.
- Healthcare: Improvement of cell-based therapies.
- Research Opportunities: Expanded apoptosis detection methods.
Case Studies
- Improved yields in hematopoietic stem cell therapy.
- Enhanced analysis in cancer research studies.
IP Status
Intellectual Property: Filed patent in India, Application No: 2020541102567,
dated April 15th, 2020.
Support Offered
- Licensing Options: Non-exclusive licensing available
- Technical Support: Training and guidance provided
- Collaboration Opportunities: Joint development projects available