Triple-Negative Breast Cancer Database

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3. Zhang, B., et al., Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. Cancer Sci, 2010. 101(6): p. 1536-42. PMID:20384629
4. Yu, X., et al., Diversin is overexpressed in breast cancer and accelerates cell proliferation and invasion. PLoS One, 2014. 9(5): p. e98591. PMID:24858714
5. Yang, L., et al., FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene, 2011. 30(43): p. 4437-46. PMID:21532620
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7. Yamamoto, M., et al., Epigenetic alteration of the NF-kappaB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. Cancer Sci, 2010. 101(11): p. 2391-7. PMID:20735436
8. Xia, H., et al., Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem, 2013. 288(37): p. 26731-40. PMID:23913682
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10. Wong, T.S., et al., High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients. Clin Cancer Res, 2002. 8(2): p. 433-7. PMID:11839660
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12. Wen, Y.H., et al., Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation. Breast Cancer Res Treat, 2012. 135(1): p. 93-102. PMID:22538771
13. Wang, X., et al., CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. J Natl Cancer Inst, 2010. 102(19): p. 1496-512. PMID:20852124
14. Wang, W., et al., IRP2 regulates breast tumor growth. Cancer Res, 2014. 74(2): p. 497-507. PMID:24285726
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16. Tuhkanen, H., et al., Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer. Int J Cancer, 2013. 133(10): p. 2334-40. PMID:23649491
17. Sinha, A., et al., Down regulation of SPAG9 reduces growth and invasive potential of triple-negative breast cancer cells: possible implications in targeted therapy. J Exp Clin Cancer Res, 2013. 32(1): p. 69. PMID:24330581
18. Salimi, M., H. Mozdarani, and K. Majidzadeh, Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients. Med Oncol, 2012. 29(3): p. 1502-9. PMID:21850541
19. Rodriguez-Acebes, S., et al., Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Pathol, 2010. 177(4): p. 2034-45. PMID:20724597
20. Ren, Y., et al., microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast cancer cells. Mol Med Rep, 2014. 10(1): p. 315-21. PMID:24821285
21. Pula, B., et al., Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma. Cell Oncol (Dordr), 2013. 36(6): p. 469-83. PMID:24065215
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23. Pelekanou, V., et al., ERalpha36, a new variant of the ERalpha is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines. Steroids, 2012. 77(10): p. 928-34. PMID:22198466
24. Paul, A., et al., PKClambda/iota signaling promotes triple-negative breast cancer growth and metastasis. Cell Death Differ, 2014. PMID:24786829
25. Passon, N., et al., Expression of Dicer and Drosha in triple-negative breast cancer. J Clin Pathol, 2012. 65(4): p. 320-6. PMID:22259182
26. Ortiz-Martinez, F., et al., Association of increased osteopontin and splice variant-c mRNA expression with HER2 and triple-negative/basal-like breast carcinomas subtypes and recurrence. Hum Pathol, 2014. 45(3): p. 504-12. PMID:24440093
27. Nozoe, T., et al., Immunohistochemical expression of epidermal growth factor receptor in breast cancer. Breast Cancer, 2011. 18(1): p. 37-41. PMID:20204554
28. Neve, R.M., et al., A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 2006. 10(6): p. 515-27. PMID:17157791
29. Muniz Lino, M.A., et al., Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9. J Proteomics, 2014. PMID:24768906
30. Montero, J.C., et al., Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer. Oncogene, 2014. 33(2): p. 148-56. PMID:23246963
31. Mittendorf, E.A., et al., PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res, 2014. 2(4): p. 361-70. PMID:24764583
32. Miki, Y., et al., Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res, 2006. 66(1): p. 535-42. PMID:16397270
33. Meric, F., et al., Expression profile of tyrosine kinases in breast cancer. Clin Cancer Res, 2002. 8(2): p. 361-7. PMID:11839650
34. McDonald, L., et al., RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Dis Model Mech, 2014. 7(5): p. 525-34. PMID:24626992
35. Mackiewicz, M., et al., Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. Breast Cancer Res Treat, 2011. 130(2): p. 663-79. PMID:21814748
36. Lu, M., et al., Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer. Clin Proteomics, 2010. 6(3): p. 93-103. PMID:20930921
37. Liu, X., et al., Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis. BMC Cancer, 2014. 14: p. 57. PMID:24485087
38. Lee, S.T., et al., Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A, 2013. 110(27): p. 11121-6. PMID:23784775
39. Kulkarni, S., et al., Increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer. PLoS One, 2012. 7(8): p. e42895. PMID:22952619
40. Krishnan, K., et al., miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA, 2013. 19(12): p. 1767-80. PMID:24158791
41. Kong, C., et al., NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS One, 2011. 6(7): p. e22666. PMID:21829474
42. Kim, Y.J., et al., MET is a potential target for use in combination therapy with EGFR inhibition in triple-negative/basal-like breast cancer. Int J Cancer, 2014. 134(10): p. 2424-36. PMID:24615768
43. Kim, I.J., et al., RET oligonucleotide microarray for the detection of RET mutations in multiple endocrine neoplasia type 2 syndromes. Clin Cancer Res, 2002. 8(2): p. 457-63. PMID:11839664
44. Kharman-Biz, A., et al., Expression of activator protein-1 (AP-1) family members in breast cancer. BMC Cancer, 2013. 13: p. 441. PMID:24073962
45. Kerdivel, G., et al., Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines. Mol Cell Endocrinol, 2014. 390(1-2): p. 34-44. PMID:24721635
46. Kalashnikova, E.V., et al., ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res, 2010. 70(22): p. 9402-12. PMID:20864510
47. Inagawa, S., et al., Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res, 2002. 8(2): p. 450-6. PMID:11839663
48. Huck, B., et al., Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem, 2014. 289(6): p. 3138-47. PMID:24337579
49. Hu, Z., et al., The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics, 2006. 7: p. 96. PMID:16643655
50. Horiuchi, D., et al., MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med, 2012. 209(4): p. 679-96. PMID:22430491
51. Holm, K., et al., Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes. Mol Oncol, 2012. 6(5): p. 494-506. PMID:22766277
52. Grigoriadis, A., et al., Molecular characterisation of cell line models for triple-negative breast cancers. BMC Genomics, 2012. 13: p. 619. PMID:23151021
53. Grieb, B.C., X. Chen, and C.M. Eischen, MTBP is Over-expressed in Triple Negative Breast Cancer and Contributes to its Growth and Survival. Mol Cancer Res, 2014. PMID:24866769
54. Geiger, T., et al., Proteomic portrait of human breast cancer progression identifies novel prognostic markers. Cancer Res, 2012. 72(9): p. 2428-39. PMID:22414580
55. Gartner, S., et al., PTK 7 is a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement. PLoS One, 2014. 9(1): p. e84472. PMID:24409301
56. Flatmark, K., et al., Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients. Clin Cancer Res, 2002. 8(2): p. 444-9. PMID:11839662
57. Feigin, M.E., et al., G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proc Natl Acad Sci U S A, 2014. 111(11): p. 4191-6. PMID:24599592
58. Fagan-Solis, K.D., et al., The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem, 2013. 114(6): p. 1385-94. PMID:23255405
59. Fagan-Solis, K.D., et al., SKP2 Overexpression Is Associated With Increased Serine 10 Phosphorylation of p27 (pSer10p27) in Triple-Negative Breast Cancer. J Cell Physiol, 2014. 229(9): p. 1160-9. PMID:24443386
60. Eswaran, J., et al., Transcriptomic landscape of breast cancers through mRNA sequencing. Sci Rep, 2012. 2: p. 264. PMID:22355776
61. Esnakula, A.K., et al., Strong association of fascin expression with triple negative breast cancer and basal-like phenotype in African-American women. J Clin Pathol, 2014. 67(2): p. 153-60. PMID:23986556
62. Duncan, J.S., et al., Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell, 2012. 149(2): p. 307-21. PMID:22500798
63. Dey, N., et al., Differential activation of Wnt-beta-catenin pathway in triple negative breast cancer increases MMP7 in a PTEN dependent manner. PLoS One, 2013. 8(10): p. e77425. PMID:24143235
64. Dennison, J.B., et al., Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer. Clin Cancer Res, 2013. 19(13): p. 3703-13. PMID:23697991
65. De Summa, S., et al., Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. Cell Death Dis, 2014. 5: p. e1076. PMID:24556691
66. D'Alfonso, T.M., et al., Axl receptor tyrosine kinase expression in breast cancer. J Clin Pathol, 2014. PMID:24904064
67. Cuenca-Lopez, M.D., et al., Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling. BMC Cancer, 2014. 14(1): p. 302. PMID:24779793
68. Cheng, G., et al., HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2. Cancer Res, 2014. 74(3): p. 862-72. PMID:24295734
69. Cheng, D., H. Kong, and Y. Li, TMPRSS4 as a poor prognostic factor for triple-negative breast cancer. Int J Mol Sci, 2013. 14(7): p. 14659-68. PMID:23857060
70. Chan, M.W., et al., Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res, 2002. 8(2): p. 464-70. PMID:11839665
71. Calvano Filho, C.M., et al., Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p. Tumour Biol, 2014. PMID:24810926
72. Brabender, J., et al., The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Clin Cancer Res, 2002. 8(2): p. 438-43. PMID:11839661
73. Blanchard, Z., et al., Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative. PLoS One, 2014. 9(4): p. e95663. PMID:24789045
74. Benad, P., et al., The anti-progestin RU-486 inhibits viability of MCF-7 breast cancer cells by suppressing WNT1. Cancer Lett, 2011. 312(1): p. 101-8. PMID:21899945
75. Ben Gacem, R., et al., Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers. Hum Pathol, 2012. 43(10): p. 1731-8. PMID:22520950
76. Bailey, C.K., et al., High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG. J Biol Chem, 2012. 287(23): p. 19472-86. PMID:22496452
77. Aydogdu, E., et al., MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer. Carcinogenesis, 2012. 33(8): p. 1502-11. PMID:22562546
78. Avery-Kiejda, K.A., et al., Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer. BMC Cancer, 2014. 14: p. 51. PMID:24479446
79. Avery-Kiejda, K.A., et al., The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer. BMC Cancer, 2014. 14: p. 253. PMID:24725360
80. Albeck, J.G. and J.S. Brugge, Uncovering a tumor suppressor for triple-negative breast cancers. Cell, 2011. 144(5): p. 638-40. PMID:21376226
81. Ahn, S.G., et al., LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients. Breast Cancer Res Treat, 2013. 141(1): p. 89-99. PMID:23933800
82. Bernemann, C., et al., Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling. Mol Cancer, 2014. 13: p. 174. PMID:25033833
83. Ziegler, Y.S., et al., Plasma membrane proteomics of human breast cancer cell lines identifies potential targets for breast cancer diagnosis and treatment. PLoS One, 2014. 9(7): p. e102341. PMID:25029196
84. Sizemore, G.M., et al., GABA(A) Receptor pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration Through Activation of Extracellular Regulated Kinase 1/2 (ERK1/2). J Biol Chem, 2014. PMID:25012653
85. Cascione, L., et al., Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. PLoS One, 2013. 8(2): p. e55910. PMID:23405235
86. Komatsu, M., et al., Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis. Int J Oncol, 2013. 42(2): p. 478-506. PMID:23254957
87. Lehmann, B.D., et al., Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest, 2011. 121(7): p. 2750-67. PMID:21633166
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