Profile

The ability to resolve how different nanoparticle (NP)-properties affect cellular interactions is critical for understanding nanoconstructs' design-activity-relationships, which can open important avenues in anti-cancer and immunotherapy research. Questions like 1) Which NP-shape is most efficient in finding specific receptors on cell-membrane and why? 2) What NP-surface ligand density is optimal for an efficient targeted interaction? 3) What aspects in nanoconstruct-designs can ensure successful endosomal escapes? etc., require more information at the single NP level. Our lab focuses on 1) Designing nanoconstructs for therapeutic and/or imaging applications. 2) Probing of single nanoconstruct-cell interaction in real-time. 3) Establishing ingenious strategies for in situ identification of different nanoconstruct-designs for high-throughput screening.