Pharmacogenetics

1

HLA-B5701

PCR

Blood

Detects human leukocyte antigen-B (HLA-B) 5701 allele, which is associated with hypersensitivity to the anti-HIV drug abacavir

2

IL28B

PCR

Blood

Detects a dinucleotide frame-shift variant coding for interleukin 28B (IL28B) and helps to predict the therapeutic response in Hepatitis C Virus infected patients

3

Statin-induced myopathy

PCR

Blood

Detects a variant in human solute carrier organic anion transporter family member IBI gene in patients who are at higher risk for developing statin-induced myopathy

4

Vitamin K Epoxide Reductase Complex 1 (VKORCI)

PCR

Blood

Detects the most important polymorphism in the Vitamin K Epoxide Reductase Complex 1 (VKORCI) gene associated with interindividual dose requirements for oral anticoagulants

5

CYP2C9

Multiplex PCR

Blood

Simultaneous detection of CYP2C9 (c.430C>T) and CYP2C9 '3 (c.i 075A>C) polymorphisms to determine the drug response of coumarin-based anticoagulation therapy

6

FCGR

PCR-Hybridization

Blood

Detection of allelic variants of FC gamma-Receptor 2A (HI 31 R) and 3A (Fl 58V) associated with response to IgG antibody therapy

7

PGX-5FU

PCR-Hybridization

Blood

Detection of DPYD allelic variant IVSI 4+1 G>A associated with toxicity of 5-FU therapy

8

PGX- CYP2C19

PCR-Hybridization

Blood

Testing for CYP2C19 variants *3, *5, *7, *8 and 7

9

PGX - CYP2D6

PCR-Hybridization

Blood

Testing for CYP2D6 variants *3, *4 and *6

10

PGX-HIV

PCR-Hybridization

Blood

Testing for genotypes associated with response to HIV highly active anti-retroviral therapy

11

PGX-Thrombo

PCR-Hybridization

Blood

Testing for CYP2C9 and VKORCI variants associated with anticoagulant dose requirements

12

PGX-TPMT

PCR-Hybridization

Blood

Testing for TPMT variants *2, *3A, *3B and *3C associated with response to thiopurine therapy