Rajiv Gandhi Centre for Biotechnology (RGCB), Department of Biotechnology, Government of India

Estrogen receptor alpha dynamics and plasticity during endocrine resistance

Sivasailam A, Kumar KS, Jayaprasad AG, Jancy SV, Harikumar A, Unnikrishnan PS, Sivakumar KC, Tiffee PJJ, Halikar AM, Nithin SS, Pillai PR, Tiwari SK, Sanjeev VS, Surabhi AV, Santhoshkumar TR (2025)

Biol Direct 2025 Jun 13;20(1):70. doi: 10.1186/s13062-025-00653-8.

Structural regression modelling of peptide based drug delivery vectors for targeted anti-cancer therapy.

Christian Y, Redkar AS, Kumar N, Jancy SV, Chandrasekharan A, Retnabai Santhoshkumar T , Ramakrishnan V. (2024)

Drug Deliv Transl Res. 2024 Aug 8. doi: 10.1007/s13346-024-01674-y.

Telomerase inhibitors induce mitochondrial oxidation and DNA damage-dependent cell death rescued by Bcl-2/Bcl-xL

Aparna Geetha Jayaprasad, Aneesh Chandrasekharan, S.P. Arun Jyothi, S.M. John Sam, T.R. Santhoshkumar, M. Radhakrishna Pillai (2024)

International Journal of Biological Macromolecules doi.org/10.1016/j.ijbiomac.2024.130151

Genetically encoded caspase sensor and RFP-LC3 for temporal analysis of apoptosis-autophagy.

Chandrasekharan A, Tiwari SK, Munirpasha HA, Sivasailam A, Jayaprasad AG, Harikumar A, Santhoshkumar TR (2023)

Int J Biol Macromol doi: 10.1016/j.ijbiomac.2023.128807

A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity.

Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones , Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam, Thankayyan Retnabai Santhoshkumar (2023)

Biological Procedures Online doi.org/10.1186/s12575-023-00214-1

Real-time simultaneous imaging of temporal alterations in cytoplasmic and mitochondrial redox in single cells during cell division and cell death

Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Asha Lekshmi, T R Santhoshkumar (2022)

Free Radical Biology and Medicine doi.org/10.1016/j.freeradbiomed.2022.11.031

A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies.

Santhik Subhasingh Lupitha, Pramod Darvin, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Soumya Jaya Divakaran, Sreekumar Easwaran, Shijulal Nelson-Sathi, Perunthottathu K Umasankar, Sara Jones, Iype Joseph, Madhavan Radhakrishna Pillai, Thankayyan Retnabai Santhoshkumar (2022)

Antibody Therapeutics doi.org/10.1093/abt/tbac007

Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.

Rishith Ravindran, Anoop Kumar G Velikkakath, Nikhil Dev Narendradev, Aneesh Chandrasekharan, T R Santhoshkumar, Srinivasa M Srinivasula (2022)

Autophagy doi.org/10.1080/15548627.2022.2052460

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine.

Seervi M., Rani A., Sharma A.K., Santhosh Kumar T.R.(2018)

Biomed Pharmacother 106, 200-209.

Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced ROS-mediated p53 independent apoptosis in cancer cells.

Ahmad N., Sharma A.K., Sharma S., Khan I., Sharma D.K., Shamsi A., Santhosh Kumar T.R., Seervi M., (2018)

Drug Chem Toxicol. doi: 10.1080/01480545.2018.1463241.

Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines.

Dan V.M., Muralikrishnan B., Sanawar R., J S.V., Burkul B.B., Srinivas K.P., Lekshmi A., Pradeep N.S., Dastager S.G., Santhakumari B., Santhoshkumar T.R, M Kumar R.A., Pillai M.R., 2018.

Sci. Rep. 8, 2810.

Strategies for imaging mitophagy in high-resolution and high-throughput.

Indira, D., Varadarajan, S.N., Subhasingh Lupitha, S., Lekshmi, A., Mathew, K.A., Chandrasekharan, A., Rajappan Pillai, P., Pulikkal Kadamberi, I., Ramachandran, I., Sekar, H., KochucherukkanGopalakrishnan, A., Tr S.( 2018)

European journal of cell biology 97(1): 1-14.

A Real-Time Image-Based Approach to Distinguish and Discriminate Apoptosis from Necrosis.

Lekshmi, A., Varadarajan, S.N., Lupitha, S.S., Nair, M., Chandrasekharan, A., Santhoshkumar T.R.(2018).

Current protocols in toxicology 21;75:2.27.1-2.27.16

Santhosh Kumar T . R, PhD

Scientist G

Selected Publications