Development of Genetically encoded fluorescent single cell
sensor for cell death and ACE2-RBD-S protein binding
inhibition
Department of Biotechnology [DBT]
Research Summary
Major areas of our research are listed below
- Understanding the dynamics of functional heterogeneity of cancer cells and their role in tumor progression and disease resistance
- Role of cell cycle status in drug response heterogeneity
- Mechanisms of Hormone resistance in breast cancer
- Development of Cancer Drug Discovery assays and approaches for in Vitro screening and preclinical validation of cancer drugs
- Epigenetic modulation of triple negative breast cancer cells and its role in disease resistance using Patient Derived TNBC xenografts
Current Research Grants
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2024 2022
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2023 2019
Establishment of Fast-Lifetime imaging facility
Department of Biotechnology [DBT]
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2023 2020
Design and Characterization of peptide based cell targeting domains with live cell and animal imaging methods
Department of Biotechnology [DBT]
Previous/ Completed Research Grants
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Understanding epigenetic changes and cell state transitions that contribute for recurrence in triple negative breast cancers
Department of Biotechnology [DBT] 2017-2020Understanding the role of Hypoxia induced mitophagy in cancer cell survival and drug resistance : Implications on tumor stem cell like cells
SERB, Department of Science and Technology [DST] 2017-2020Development Of Telomerase Over Expressing Immortalized Endothelial Cells For Cardiovascular Tissue Engineering
LSRB, Defence Research and Development Organisation [DRDO] 2006-2009Bax & Bak Independent Cell Death: Search For Its Signaling Intermediates As A Target Against Drug Resistance,
Department of Biotechnology [DBT] 2009-2010Isolation of endothelial progenitor cells from umbilical cord for tissue engineering
Department of Biotechnology [DBT] 2008-2011Search for Point of No Returnof apoptosis and the role of anti apoptotic proteins
IYBA Award, Department of Biotechnology [DBT] 2006-2009Heat Shock Protein Inhibitors as potential agents to bypass drug resistance in cancer
Department of Science and Technology [DST] 2006-2009Heat shock proteins as a molecular toolfor assessing outcome of therapy - A study using cancer cell lines
Kerala State Council for Science, Technology and Environment [KSCSTE] 2002-2004Studies on NF-kB, IkB and HSP70 proteins in cancer cell lines (Co PI)
LSRB, Defence Research and Development Organisation [DRDO] 2003-2005Development of nonthrombogenicEndothelial cells by Bcl2 gene transfer for tissue Engineering
Department of Science and Technology [DST] 2002-2005Development of Bid-Ds red, Cytochrome c -GFP,AIF-GFPstable cells as a screening tool for large scale anticancer drug evaluation
Kerala State Council for Science, Technology and Environment [KSCSTE] 2004-2005Smac YFPexpressing cells as novel cell based assays for large scale screeningofplant derived compounds for anticancer property
International Foundation of Science,Sweden 2004-2005Development ofnew generation FRET probes for CASPASE
Department of Biotechnology [DBT] 2013-2016
