Andrographis paniculata, commonly known as ‘Kalmegh’ or ‘Nilavembu’, is a perennial herbaceous medicinal plant. The therapeutic activity of A. paniculata has been attributed to Andrographolide, a bicyclic diterpenoid lactone present in the whole plant. Microbial symbionts are reported to promote biomass and secondary metabolite production in plants through nutrient acquisition, growth promotion, and protection against biotic and abiotic stresses. Piriformospora indica is an axenically cultivable phytopromotional and wide-host root-colonizing endosymbiotic fungus with many biotechnological applications including enhancement of growth and secondary metabolite production in plants. My work is focused on co-cultivating in vitro cultures of A. paniculata and P. indica to analyse the molecular effects of P. indica co-cultivation leading to the changes in Andrographolide production. The work also extends to fractionation of cell wall extract of P. indica to identify the active cell wall fractions which can induce enhanced Andrographolide production.
Identification and functional characterization of pathogenic effectors from the oomycete Phytophthora capsici Leonian.
Elucidation of functional roles of key secondary metabolite pathway genes in Piper nigrum L : Exploring the potential of 'priming' as a possible crop protection strategy.
Identification and functional characterization of Phytophthora capsici effectors specific to 'quick wilt' disease in black pepper (Piper nigrum).
Transcriptome analysis and characterization of key metabolic and hormone signalling pathway genes in Piper nigrum in response to defense elicitors.
Gayathri G S
Laboratory management assistance.
Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post,
Poojappura, Thiruvananthapuram - 695 014, Kerala, India +91-471-2529400
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