Rajiv Gandhi Centre for Biotechnology (RGCB), Department of Biotechnology, Government of India

Bacterial pore forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection

Saba Parveen, Chinmayi V. Bhat, Aswathy C S, Shaheena Aziz, Arya J, Asmita Dutta, Somit Dutta, Sautan Show, Kuldeep Sharma, Sumit Rakshit, John Bernet Johnson, Upendra Nongthomba, Anirban Banerjee, Karthik Subramanian (2024)

iScience (Cell) https://doi.org/10.1016/j.isci.2024.110589

Editorial: Deceiving the host: mechanisms of immune evasion and survival by pneumococcal bacteria

Karthik Subramanian and Anirban Banerjee (2023)

Frontiers in Cellular and Infection Microbiology https://doi.org/10.3389/fcimb.2023.1231253

Emerging Roles of Extracellular Vesicles in Pneumococcal Infections: Immunomodulators to Potential Novel Vaccine Candidates.

Saba Parveen and Karthik Subramanian (2022)

Frontiers in Cellular and Infection Microbiology
https://doi.org/10.3389/fcimb.2022.836070
Impact Factor: 5.3

Mannose receptor-derived peptides neutralize toxins and reduce inflammation and pneumococcal disease.

Karthik Subramanian, Federico Iovino, Vasiliki Vasiliki Tsikourkitoudi, Padryk Merkl, Sultan Ahmed, Samuel Berry, Marie-Stephanie Aschtgen, Mattias Svensson, Peter Bergman, Georgios Sotiriou, Birgitta Henriques Normark (2020)

EMBO Molecular Medicine
Doi: https://doi.org/10.15252/emmm.202012695
Impact Factor: 10.28

Emerging concepts in the pathogenesis of Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen.

Subramanian K, Henriques-Normark B, Normark S (2019)

Cellular Microbiology Volume: 10 PP: 13077
Impact Factor: 3.430
(Top Downloaded Paper 2018-2019)

Pneumolysin binds to the mannose receptor C type lectin 1(MRC-1) leading toanti-inflammatory responses and enhanced pneumococcal survival.

Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren P, Plant L, Kadioglu A, Henriques- Normark B (2019)

Nature microbiology Volume: 4 PP: 62-70
Impact Factor: 15.54
(Recommended article in Faculty of 1000 prime)

Genomic characterization of the emerging pathogen Streptococcus pseudopneumoniae.

Garriss G, Nannapaneni P, Simões AS, Browall S, Subramanian K, Sá-Leão R, Goossens H, de Lencastre H, Henriques-Normark B (2019)

mBio Volume: 10 PP: 1286-19
Impact Factor: 6.784

Vitamin D promotes pneumococcal killing and modulates inflammatory response in primary human neutrophils.

Subramanian K, Bergman P, Henriques-Normark B (2017)

Journal of Innate Immunity Volume: 9 PP: 375-386
Impact Factor: 4.932

See complete publication list

Karthik Subramanian, PhD

Scientist C & DBT-Ramalingaswami Faculty Fellow

Selected Publications