Selected Publications
Extracellular Vesicle-Bound Bacterial Toxin Pneumolysin Triggers Membrane Engagement and Damage Beyond Canonical Pore Formation.
Aswathy C. Sagilkumar, Avinashi Lal Kushwaha, Anushka Shitut, Dheeraj Kumar Sarkar, Sruthika Sukumar, Subhajit Mahanty, Somnath Dutta, Jagannath Mondal, Karthik Subramanian *. (2026)
Journal of Extracellular Vesicles
2026 Oct;15(10):e70387. doi: 10.1002/jev2.70387.
Impact factor 21.7 (Highlighted by Nature India; Press Trust of India; UNIINDIA)(*Corresponding Author)
Beyond Antibiotics: Can We Fight Drug-Resistant Pneumonia Without Traditional Antibiotics?
Subramanian K (2026)
Science Factors https://doi.org/10.67831/Sci.Factors.2026.1412
Sorafenib, a clinical kinase inhibitor, attenuates Streptococcus pneumoniae pathogenesis and reduces disease progression in vivo.
Abraham J, Sagilkumar AC, Dhyani H, Panchal CM, Aziz S, Priyadatha MK, Ruth A, Bhaskaran K, Chandrika SK, Shaima S, Varghese R, Neeravi A, Veeraragavan B, Narayanaswamy N, Ganesan S, Subramanian K*.(2026)
mBio 2026 Jul 8;17(7):e0061826. doi: 10.1128/mbio.00618-26(Highlighted by Nature India; Press Trust of India; The Print; Researcher Spotlight by Biopatrika) (*Corresponding Author)
Bacterial pore forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
Saba Parveen, Chinmayi V. Bhat, Aswathy C S, Shaheena Aziz, Arya J, Asmita Dutta, Somit Dutta, Sautan Show, Kuldeep Sharma, Sumit Rakshit, John Bernet Johnson, Upendra Nongthomba, Anirban Banerjee, Karthik Subramanian (2024)
iScience (Cell) https://doi.org/10.1016/j.isci.2024.110589
Editorial: Deceiving the host: mechanisms of immune evasion and survival by pneumococcal bacteria
Karthik Subramanian and Anirban Banerjee (2023)
Frontiers in Cellular and Infection Microbiology https://doi.org/10.3389/fcimb.2023.1231253
Emerging Roles of Extracellular Vesicles in Pneumococcal Infections: Immunomodulators to Potential Novel Vaccine Candidates.
Saba Parveen and Karthik Subramanian (2022)
Frontiers in Cellular and Infection Microbiology
https://doi.org/10.3389/fcimb.2022.836070
Impact Factor: 5.3
Mannose receptor-derived peptides neutralize toxins and reduce inflammation and pneumococcal disease.
Karthik Subramanian, Federico Iovino, Vasiliki Vasiliki Tsikourkitoudi, Padryk Merkl, Sultan Ahmed, Samuel Berry, Marie-Stephanie Aschtgen, Mattias Svensson, Peter Bergman, Georgios Sotiriou, Birgitta Henriques Normark (2020)
EMBO Molecular Medicine
Doi: https://doi.org/10.15252/emmm.202012695
Impact Factor: 10.28
Emerging concepts in the pathogenesis of Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen.
Subramanian K, Henriques-Normark B, Normark S (2019)
Cellular Microbiology
Volume: 10 PP: 13077
Impact Factor: 3.430
(Top Downloaded Paper 2018-2019)
Pneumolysin binds to the mannose receptor C type lectin 1(MRC-1) leading toanti-inflammatory responses and enhanced pneumococcal survival.
Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren P, Plant L, Kadioglu A, Henriques- Normark B (2019)
Nature microbiology
Volume: 4 PP: 62-70
Impact Factor: 15.54
(Recommended article in Faculty of 1000 prime)
Genomic characterization of the emerging pathogen Streptococcus pseudopneumoniae.
Garriss G, Nannapaneni P, Simões AS, Browall S, Subramanian K, Sá-Leão R, Goossens H, de Lencastre H, Henriques-Normark B (2019)
mBio
Volume: 10 PP: 1286-19
Impact Factor: 6.784
Vitamin D promotes pneumococcal killing and modulates inflammatory response in primary human neutrophils.
Subramanian K, Bergman P, Henriques-Normark B (2017)
Journal of Innate Immunity
Volume: 9 PP: 375-386
Impact Factor: 4.932