Research Programs


Germline stem cell maintenance, division and differentiation in testis


Factors regulating meiotic drive in testis


Critical molecules regulating biomembrane structure and cell fusion during fertilization


Cellular Deprogramming during fertilization

Previous/ Completed Research Grants

    1. Isolation of germline stem cells from adult mouse testis and evaluation of their pluripotency
      Department of Biotechnology [DBT] 2010-2011

    2. Charcterization of testis-specific tyramine receptor like protein (TRLP)
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2008-2011

    3. Cloning, expression and functional characterization of a cyclin-like protein (CLP-1) from human germ cells
      Department of Science and Technology [DST] 2008-2011

    4. Sperm proteome profiling in human male infertility
      Department of Biotechnology [DBT]-National Bioscience Award Project 2007-2010

    5. Cloning, expression and semiquantitative analysis of protocadherins in human germ cells
      Council of Scientific and Industrial Research [CSIR] 2006-2009

    6. Characterization of RAFTS and RAFT-associated proteins of spermatozoa during capacitation and acrosome reaction
      Department of Biotechnology [DBT] 2006-2009

    7. Evaluation of the expression of a sterility locus gene TCTEX-1 and its relation with protein trafficking in spermatozoa from infertile and fertile human males
      Board of Research in Nuclear Sciences [BRNS] 2006-2009

    8. Mechanism of activation of NADPH Oxidase in blue-light signal transduction reactions in the coleoptile tip
      Department of Science and Technology [DST] 2004-2008

    9. Identification of superoxide generating machinery in mammalian spermatozoa
      Department of Science and Technology [DST] 2003-2007

    10. Charactrization of 54 kilodalton uterine protein and its involvement in early pregnancy
      University Grants Commission [UGC] 2002-2005

    11. Characterization of A/V CAM from human spermatozoa and its involvement in normal human fertility
      Department of Biotechnology [DBT] 2000-2004

    12. Biophysical and immunological aspects of the perturbations in post-vasectomy spermatozoa and its relation in irreversibility of fertility
      Council of Scientific and Industrial Research [CSIR] 1996-2000

    13. Isolation, purification and characterization of a transiently appearing endometrial adhesion molecule (EAM) in the mouse
      Department Of Atomic Energy [DAE] 1992-1995

    14. Active oxygen intermediates in female reproduction and the physico-chemical aspects of membrane configuration as a consequence of oxidative mechanisms at implantation
      Department of Science and Technology [DST] 1992-1995

    15. Free radical modulation of the physico-chemical architecture of mammalian sperm membranes and the molecular aspects of sperm-zona pellucida interaction
      Department of Science and Technology [DST] 1992-1995

    16. Studies on the isolation, purification and structural and functional characterization of Fc receptors from mammalian sperm
      Council of Scientific and Industrial Research [CSIR] 1990-1992

    17. Insect pest management through secondary plant metabolites: control of forest pest and mosquitoes
      M.P Council of Science and Technology 1988-1991

    1. Sponsored Grants

    2. Role of CLP-1 in cell cycle regulation in spermatogenic cells
      Department of Science and Technology [DST] 2013-2016

    3. Evaluation of cellular aging and genome stability in spermatogonial stem cells
      Council of Scientific and Industrial Research [CSIR] 2013-2016

    4. Association between stemness and TCTEX1 expression in testicular germ cells from adult mouse
      Board of Research in Nuclear Sciences [BRNS] 2011-2014

    5. Structural and phosphoproteome analysis of mouse sperm membrane rafts during their interaction with zona pellucida protein
      Department of Biotechnology [DBT] 2011-2014


Rajiv Gandhi Centre for Biotechnology (RGCB),
Thycaud Post, Poojappura,
Thiruvananthapuram - 695 014, Kerala, India
+91-471-2529400 | 2347975 | 2348753

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