Reprogramming of satellite cells for cardiac repair.
Skeletal muscle has a remarkable ability to regenerate after injury by a highly orchestrated degeneration at the tissue, cellular, and molecular levels. It greatly relies on the dynamic interplay between satellite cells and their environment. The self-renewing capability of satellite cells is clearly demonstrated by their remarkable ability to sustain the capacity of muscle to regenerate. A recent report describing the successful transdifferentiation of somatic cells to a cardiac fate invitro has raised the possibility that this process might eventually be used for cell-based cardiac therapy. These myocytes possess similar characteristics to the endogenous cardiomyocytes such as cardiac gene expression, sarcomere structure, and electrophysiological features. We hypothesized that a brief reactivation of programming factors in satellite cells by different inductive signals can induce pluripotency. Further, overexpression of the master regulatory transcription factors which control the gene networks can convert it into cardiomyocytes like cells. The resulting new cell type can then be used for patient-speci?c disease modeling, drug screening, or regenerative medicine.
Neeraja K M
Regulation and processing of mRNA 3'UTR in cancer cell invasion and metastasis.
Malaya Ranjan Behera
Sneha Sandra P S
Role of Poly (A) tailing in mRNA stabilization in E. coli and it's physiological significance.
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