Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen.

Aravind Madhavan, Arun K B, Akhil Raj Pushparajan, Balaji M and R Ajay Kumar(2020)
bioRxiv     doi:https://doi.org/10.1101/2020.06.22.164350

Spatial separation of Streptomyces aerial mycelium during fermentation enhances secondary metabolite production.

Balaji Muralikrishnan, Retnakumar R, Ranjit Ramachandran, Vinodh J S, Nijisha M, Arun K B, Laiza Paul, Syed Gulam Dastager, Vipin Mohan Dan, Ajay Kumar Ramakrishnan.(2020)
bioRxiv     doi: https://doi.org/10.1101/2020.05.27.118091

Mycobacterium tuberculosis TetR family transcriptional regulator Rv1019 is a negative regulator of the mfd-mazG operon encoding DNA repair proteins.

Akhil Raj Pushparajan, Ranjit Ramachandran, Jijimole Gopi Reji,Ramakrishnan Ajay Kumar(2020)
FEBS Letters     DOI: 10.1002/1873-3468.13861

Acetylation of isoniazid - a novel mechanism of isoniazid resistance in Mycobacterium tuberculosis.

K. B. Arun, Aravind Madhavan, Billu Abraham, M. Balaji, K. C. Sivakumar, P. Nisha, R. Ajay Kumar(2020)
bioRxiv     doi: https://doi.org/10.1101/2020.02.10.941252

Comparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation.

Sajith Raghunandanan,Leny Jose,Vipin Gopinath and Ramakrishnan Ajay Kumar (2019)
Scientific Reports     9:3660. DOI:10.1038/s41598-019-40051-5.

Dormant Mycobacterium tuberculosis converts isoniazid to the active drug in a Wayne's model of dormancy.

Sajith Raghunandanan, Leny Jose and Ramakrishnan Ajay Kumar (2018)
The Journal of Antibiotics     doi: 10.1038/s41429-018-0098-z.

Submissions

  • Public Data Repositories

    1. Profiling the proteome of Mycobacterium tuberculosis during dormancy and reactivation
      Platform: PRIDE
      https://www.ebi.ac.uk/pride/archive/projects/PXD001158
    2. Comparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation
      Platform: MetaboLights
      https://www.ebi.ac.uk/metabolights/MTBLS304

    GenBank Submissions

    1. Streptomyces sp. OA161 16S ribosomal RNA gene, partial coding sequence. Accession number: KX364040.1
    2. Streptomyces sp. strain OA161 ATP synthase subunit beta gene, partial coding sequence. Accession number: KX364006
    3. Streptomyces sp. strain OA161 putative type II PKS ketosynthase alpha subunit gene, partial coding sequence. Accession number: KX364007
    4. Streptomyces sp. strain OA293 16S ribosomal RNA gene, partial coding sequence Accession number: KY014435.1
    5. Streptomyces sp. strain OA088 16S ribosomal RNA gene, partial coding sequence Accession number: KY014436.1

Contact

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