Selected Publications

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen.

Aravind Madhavan, Arun K B, Akhil Raj Pushparajan, Balaji M and R Ajay Kumar(2021)

mSphere (January/February 2021 Volume 6 Issue 1 e00036-21) DOI: 10.1128/mSphere.00036-21

Spatial separation of Streptomyces aerial mycelium during fermentation enhances secondary metabolite production.

Balaji Muralikrishnan, Retnakumar R, Ranjit Ramachandran, Vinodh J S, Nijisha M, Arun K B, Laiza Paul, Syed Gulam Dastager, Vipin Mohan Dan, Ajay Kumar Ramakrishnan.(2020)

bioRxiv doi: https://doi.org/10.1101/2020.05.27.118091

Mycobacterium tuberculosis TetR family transcriptional regulator Rv1019 is a negative regulator of the mfd-mazG operon encoding DNA repair proteins.

Akhil Raj Pushparajan, Ranjit Ramachandran, Jijimole Gopi Reji,Ramakrishnan Ajay Kumar(2020)

FEBS Letters DOI: 10.1002/1873-3468.13861

Acetylation of isoniazid - a novel mechanism of isoniazid resistance in Mycobacterium tuberculosis.

K. B. Arun, Aravind Madhavan, Billu Abraham, M. Balaji, K. C. Sivakumar, P. Nisha, R. Ajay Kumar (2020)

Antimicrob. Agents Chemother. doi:10.1128/AAC.00456-20 .
AAC00456-20 Supplemental files

Comparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation.

Sajith Raghunandanan,Leny Jose,Vipin Gopinath and Ramakrishnan Ajay Kumar (2019)

Scientific Reports 9:3660. DOI:10.1038/s41598-019-40051-5.

Dormant Mycobacterium tuberculosis converts isoniazid to the active drug in a Wayne's model of dormancy.

Sajith Raghunandanan, Leny Jose and Ramakrishnan Ajay Kumar (2018)

The Journal of Antibiotics doi: 10.1038/s41429-018-0098-z.

See complete publication list

Submissions

Public Data Repositories
1. Profiling the proteome of Mycobacterium tuberculosis during dormancy and reactivation
  Platform: PRIDE
  https://www.ebi.ac.uk/pride/archive/projects/PXD001158
2. Comparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation
  Platform: MetaboLights
  https://www.ebi.ac.uk/metabolights/MTBLS304
GenBank Submissions
1. Streptomyces sp. OA161 16S ribosomal RNA gene, partial coding sequence. Accession number: KX364040.1
2. Streptomyces sp. strain OA161 ATP synthase subunit beta gene, partial coding sequence. Accession number: KX364006
3. Streptomyces sp. strain OA161 putative type II PKS ketosynthase alpha subunit gene, partial coding sequence. Accession number: KX364007
4. Streptomyces sp. strain OA293 16S ribosomal RNA gene, partial coding sequence Accession number: KY014435.1
5. Streptomyces sp. strain OA088 16S ribosomal RNA gene, partial coding sequence Accession number: KY014436.1

Ajay Kumar R, PhD

Scientist G

Selected Publications

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen.

Spatial separation of Streptomyces aerial mycelium during fermentation enhances secondary metabolite production.

Mycobacterium tuberculosis TetR family transcriptional regulator Rv1019 is a negative regulator of the mfd-mazG operon encoding DNA repair proteins.

Acetylation of isoniazid - a novel mechanism of isoniazid resistance in Mycobacterium tuberculosis.

Comparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation.

Dormant Mycobacterium tuberculosis converts isoniazid to the active drug in a Wayne's model of dormancy.

Submissions

Public Data Repositories

GenBank Submissions

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