A Study on the Gut Microbiota in Autistic Children- AMetagenomic Approach
Autism Spectrum Disorders are a group of neurodevelopmental disorders defined by impairments in communication, social skills and prerequisite learning behaviour. Autistic symptoms become evident during the first 5 years of life which renders childcare difficult and pose greater economic burden on healthcare facilities in developing countries. About one-third of autistic children suffer from gastrointestinal disorders including abdominal pain, gastroesophageal reflux, diarrhoea, chronic constipation and flatulence. My study focuses on comparing the gut microbiotic profile of autistic children against the healthy controls through metagenome and metabolome analyses. The data obtained from the study will be regarded as baseline information for the development of microbial transfer and probiotic therapies to intervene irritable bowel syndrome and autism spectrum disorders in future.
Karthika S, PhD
Development of probiotic therapy for enhancing urolithin production by using bacterial flora of human origin.
Studies on the Haitian variant Vibrio cholera with special emphasis on its pathogenesis, antibiotic resistance and comparative genomics.
Devika Das J
Anti-infectious property of potential probiotic strains of human origin against Vibrio cholera.
Molecular insights into hypervirulent Klebsiella pneumoniae with special emphasis on its virulence and antibiotic resistance
Megha P R
Analysis of polymicrobial biofilms in chronic wound infections and development of anti-biofilm therapeutic to promote wound healing.
Health promoting properties of potential probiotic strains isolated from infant gut microflora.
Sudha B Nair
Senior Manager, Technical Services
Validation of conserved anti-biofilm drug target common for Vibrios.
Antony K P
Saritha K L
Laboratory management assistance.
Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post,
Poojappura, Thiruvananthapuram - 695 014, Kerala, India +91-471-2529400
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