Research Programs

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Understanding the role of Notch and Wnt signaling in neocortical and cerebellar development

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Functional characterization of homeobox gene Tlx3 (Hox11L2) in cerebellar development and its link to Autistic spectral disorders (ASD)

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Development of a cell therapy strategy to treat glaucoma using retinal ganglion cells (RGCs) generated from embryonic stem (ES) cells/ Umbilical Cord Blood (UCB) derived mesenchymal stem cells

Current Research Grants

  • 2025 2022

    Functional relevance of a unique subclass of Notch independent Hes-1 (NIHes-1) expressing neural stem cells in developing/adult cortex
    Science and Engineering Research Board [DST-SERB]

Previous/ Completed Research Grants

    1. Development of a low-cost Anosmia screening tool to mass screen asymptomatic COVID-19 carriers
      Science and Engineering Research Board [DST-SERB] 2020-2021

    2. Regulation of stemness by Pleiotropic Hes-1 expression in neuroblastoma
      National Bioscience Career Award, Dept. of Biotechnology, Govt. of India 2018-2021

    3. Expression of Notch independent Hes-1 (NIHes-1) specifically in ES derived organoids representing developing neocortex: Understanding its functional significance.
      Department of Biotechnology [DBT] 2018-2020

    4. Guiding retinal ganglion cell axons to brain visual centers: Is Pax6 the key molecule?
      Department of Science & Technology [DST] 2017-2020

    5. Transcriptional regulation of Tlx3 by Pax6 and its role on excitatory neural fate specification in vitro and in vivo.
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2014-2016

    6. Characterization of Notch independent Hes-1 mediated maintenance and fate specification of neural progenitors.
      Department of Biotechnology [DBT] 2013-2016

    7. Transcriptional regulation of Tlx3 (Hox11L2) by Notch signaling and its involvement in excitatory vs. inhibitory fate specification of neural progenitors.
      Department of Science & Technology [DST] 2013-2016

    8. Differentiation of UCB stem cells into lineage specific cell types for therapeutic applications.
      Department of Biotechnology [DBT] 2008-2011

    9. Isolation and characterization of human embryonic stem (ES) cell line.
      Kerala State Council for Science, Technology and Environment [KSCSTE] 2007-2009

    10. Development of a cell therapy strategy to treat glaucoma using retinal ganglion cells (RGCs) generated from embryonic stem (ES) cells.
      Department of Biotechnology [DBT] 2006-2009

    11. Transplantation of embryonic stem (ES) cells engineered to produce GABA into hippocampus of rats with temporal lobe epilepsy for possible control of seizures.
      Department of Science & Technology [DST] 2004-2008

Contact

Rajiv Gandhi Centre for Biotechnology (RGCB),
Thycaud Post, Poojappura,
Thiruvananthapuram - 695 014, Kerala, India
+91-471-2529400 | 2347975 | 2348753
+91-471-2348096
webmaster@rgcb.res.in

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Last Updated on: January 27, 2023
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